Gamma Delta T Cells: The Fourth Player in CD8 T Cell Immunity

Grant number: 2002682 | Funding period: 2021 - 2023

Completed

Abstract

The immune systems of animals have evolved complex but effective mechanisms to protect against infection with intracellular pathogens. This requires that T cells can distinguish uninfected cells from those harbouring pathogens. This is achieved via recognition of pathogen-derived molecules, which activate the immune system to recognise and fight the pathogen. We have identified a crucial role for a gamma delta T cells in this process, making them essential sentinels of intracellular infection.

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University of Melbourne Researchers

Lynette Beattie