Simulating and stimulating the Blood-Brain-Barrier: a platform for investigating non-pharmaceutical Alzheimer’s therapy

Grant number: 2003446 | Funding period: 2021 - 2024

Active

Abstract

Alzheimer's disease is a looming public health threat worldwide. Despite the widespread acknowledgement of this issue, there are a lack of effective drugs that can slow disease progression. This project aims to investigate a new class of non-pharmaceutical treatment methods based on controlled acoustic, electrical and optical stimulation methods to treat and reverse the base causes of Alzheimer's disease.

Related publications (7)

Scholarly works icon

Enhanced effective diffusion in sub-wavelength, axon-scale microchannels using surface acoustic waves

D Peng, W Tong, DJ Collins, MR Ibbotson, S Prawer, MEM Stamp

2023-03-01

Excitation using surface acoustic waves (SAW) has demonstrated efficacy in improving microscale particle/chemical transport due to..

Scholarly works icon

Sound-Speed Modifying Acoustic Metasurfaces for Acoustic Holography.

Mingxin Xu, William S Harley, Zhichao Ma, Peter VS Lee, David J Collins

2023-01-19

Acoustic metasurfaces offer unique capabilities to steer and direct acoustic fields, though these are generally composed of comple..

Scholarly works icon

3D Acoustofluidics via Sub-Wavelength Micro-Resonators

William Sean Harley, Kirill Kolesnik, Mingxin Xu, Daniel Edward Heath, David John Collins

2022-12-16

Precise acoustic micromanipulation is emerging as an important tool in biomedical research, where acoustic forces have the advanta..

Scholarly works icon

Microfluidic acoustic sawtooth metasurfaces for patterning and separation using traveling surface acoustic waves

Mingxin Xu, Peter VS Lee, David J Collins

2021-12-03

We demonstrate a sawtooth-based metasurface approach for flexibly orienting acoustic fields in a microfluidic device driven by sur..

Scholarly works icon

Periodic Rayleigh streaming vortices and Eckart flow arising from traveling-wave-based diffractive acoustic fields

Kirill Kolesnik, Pouya Hashemzadeh, Danli Peng, Melanie EM Stamp, Wei Tong, Vijay Rajagopal, Morteza Miansari, David J Collins

2021-10-15

Recent studies have demonstrated that periodic time-averaged acoustic fields can be produced from traveling surface acoustic waves..

Scholarly works icon

Deterministic Sorting of Submicrometer Particles and Extracellular Vesicles Using a Combined Electric and Acoustic Field

Mahnoush Tayebi, Dahou Yang, David J Collins, Ye Ai

2021-08-06

Sorting of extracellular vesicles has important applications in early stage diagnostics. Current exosome isolation techniques, how..

Scholarly works icon

Unconventional acoustic approaches for localized and designed micromanipulation

Kirill Kolesnik, Mingxin Xu, Peter VS Lee, Vijay Rajagopal, David J Collins

2021-07-16

Acoustic fields are ideal for micromanipulation, being biocompatible and with force gradients approaching the scale of single cell..