Molecular regulators of adaptive immunity to overwhelming viral infections
Grant number: 2004333 | Funding period: 2021 - 2023
Diseases caused by overwhelming viral infections, such as COVID-19, are associated with widespread impairments in immunity and constitute a major burden to human health. We have discovered that the molecule c-Myb is essential for the maintenance of immunity during chronic infection. In order to lay the foundations for novel and innovative anti-viral therapies, this project will dissect the molecular pathways regulated by c-Myb that maintain immunity during severe or chronic infection.
Related publications (1)
MYB orchestrates T cell exhaustion and response to checkpoint inhibition
Carlson Tsui, Lorenz Kretschmer, Svenja Rapelius, Sarah S Gabriel, David Chisanga, Konrad Knoepper, Daniel T Utzschneider, Simone Nuessing, Yang Liao, Teisha Mason, Santiago Valle Torres, Stephen A Wilcox, Krystian Kanev, Sebastian Jarosch, Justin Leube, Stephen L Nutt, Dietmar Zehn, Ian A Parish, Wolfgang Kastenmueller, Wei Shi
CD8+ T cells that respond to chronic viral infections or cancer are characterized by the expression of inhibitory receptors such a..