Molecular Regulators of Adaptive Immunity to Overwhelming Viral Infections

Grant number: 2004333 | Funding period: 2021 - 2023

Completed

Abstract

Diseases caused by overwhelming viral infections, such as COVID-19, are associated with widespread impairments in immunity and constitute a major burden to human health. We have discovered that the molecule c-Myb is essential for the maintenance of immunity during chronic infection. In order to lay the foundations for novel and innovative anti-viral therapies, this project will dissect the molecular pathways regulated by c-Myb that maintain immunity during severe or chronic infection.

Related publications (2)

Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression

C Gago da Graça, AA Sheikh, DM Newman, L Wen, S Li, J Shen, Y Zhang, SS Gabriel, D Chisanga, J Seow, A Poch, L Rausch, MHT Nguyen, J Singh, CH Su, LA Cluse, C Tsui, TN Burn, SL Park, B Von Scheidt

2025-01-01

Stem-like T cells are attractive immunotherapeutic targets in patients with cancer given their ability to proliferate and differen..

MYB orchestrates T cell exhaustion and response to checkpoint inhibition

C Tsui, L Kretschmer, S Rapelius, SS Gabriel, D Chisanga, K Knöpper, DT Utzschneider, S Nüssing, Y Liao, T Mason, SV Torres, SA Wilcox, K Kanev, S Jarosch, J Leube, SL Nutt, D Zehn, IA Parish, W Kastenmüller, W Shi

2022-09-08

CD8<sup>+</sup> T cells that respond to chronic viral infections or cancer are characterized by the expression of inhibitory recep..

University of Melbourne Researchers

Axel Kallies