Advancing the Spatial Analysis of Cells in Tissues to Profile the Tumour Microenvironment

Grant number: 2003887 | Funding period: 2021 - 2022

Completed

Abstract

Tumours are composed of a mix of different cells, including cancer cells, immune cells and other cells supporting tumour growth. These cells are not organised randomly, but rather are distributed in specific patterns. Here we will develop computational methods to detect these patterns and determine what statistical tests should be used to compare samples. This project will give us the tools to investigate how the location of cells in tissues relates to treatment response and survival.

Related publications (3)

Disruption of metazoan gene regulatory networks in cancer alters the balance of co-expression between genes of unicellular and multicellular origins

AS Trigos, F Bongiovanni, Y Zhang, M Zethoven, R Tothill, R Pearson, AT Papenfuss, DL Goode

2024-12-01

Background: Metazoans inherited genes from unicellular ancestors that perform essential biological processes such as cell division..

Spatial analysis with SPIAT and spaSim to characterize and simulate tissue microenvironments

Y Feng, T Yang, J Zhu, M Li, M Doyle, V Ozcoban, GT Bass, A Pizzolla, L Cain, S Weng, A Pasam, N Kocovski, YK Huang, SP Keam, TP Speed, PJ Neeson, RB Pearson, S Sandhu, DL Goode, AS Trigos

2023-12-01

Spatial proteomics technologies have revealed an underappreciated link between the location of cells in tissue microenvironments a..

Tumor immune microenvironment of primary prostate cancer with and without germline mutations in homologous recombination repair genes

AS Trigos, A Pasam, P Banks, R Wallace, C Guo, S Keam, H Thorne, C Mitchell, S Lade, D Clouston, A Hakansson, Y Liu, B Blyth, D Murphy, N Lawrentschuk, D Bolton, D Moon, P Darcy, Y Haupt, SG Williams

2022-06-01

Background Aberrations in homologous recombination repair (HRR) genes are emerging as important biomarkers for personalized treatm..

University of Melbourne Researchers

Anna Trigos