ARC Research Hub to Combat Antimicrobial Resistance

gyrA Mutations in Mycoplasma Genitalium and Their Contribution to Moxifloxacin Failure: Time for the Next Generation of Resistance-guided Therapy

Gerald L Murray, Erica L Plummer, Kaveesha Bodiyabadu, Lenka A Vodstrcil, Jose L Huaman, Jennifer A Danielewski, Teck Phui Chua, Dorothy A Machalek, Suzanne Garland, Michelle Doyle, Emma L Sweeney, David M Whiley, Catriona S Bradshaw

2023-02-01

BACKGROUND: While single nucleotide polymorphisms (SNPs) in Mycoplasma genitalium parC contribute to fluoroquinolone treatment fai..

Individualised treatment of Mycoplasma genitalium infection-incorporation of fluoroquinolone resistance testing into clinical care

Emma L Sweeney, Catriona S Bradshaw, Gerald L Murray, David M Whiley

2022-08-24

Mycoplasma genitalium is an emerging global health threat, due to an alarming rise in antimicrobial resistance. Although individua..

parC Variants in Mycoplasma genitalium: Trends over Time and Association with Moxifloxacin Failure

Gerald L Murray, Kaveesha Bodiyabadu, Lenka A Vodstrcil, Dorothy A Machalek, Jennifer Danielewski, Erica L Plummer, Suzanne M Garland, David M Whiley, Emma L Sweeney, Catriona S Bradshaw

2022-04-27

Prevalence, trends, and treatment outcome estimates were generated for parC variants in macrolide-resistant Mycoplasma genitalium...

Impact of 16S rRNA Single Nucleotide Polymorphisms on Mycoplasma genitalium Organism Load with Doxycycline Treatment

Teck-Phui Chua, Jennifer Danielewski, Kaveesha Bodiyabadu, Catriona S Bradshaw, Dorothy A Machalek, Suzanne M Garland, Erica L Plummer, Lenka A Vodstrcil, Gerald L Murray

2022-04-14

Doxycycline targets the 16S rRNA and is widely used for the treatment of sexually transmitted infections. While it is not highly e..

Novel probe-based melting curve assays for the characterization of fluoroquinolone resistance in Mycoplasma genitalium

Jacob A Tickner, Catriona S Bradshaw, Gerald L Murray, David M Whiley, Emma L Sweeney

2022-03-30

BACKGROUND: Mycoplasma genitalium infection is a sexually transmitted infection that has rapidly become resistant to mainstay trea..

Combination Therapy for Mycoplasma genitalium, and New Insights Into the Utility of parC Mutant Detection to Improve Cure

Lenka A Vodstrcil, Erica L Plummer, Michelle Doyle, Gerald L Murray, Kaveesha Bodiyabadu, Jorgen S Jensen, David Whiley, Emma Sweeney, Deborah A Williamson, Eric PF Chow, Christopher K Fairley, Catriona S Bradshaw

2022-01-04

BACKGROUND: Mycoplasma genitalium (MG) infection is challenging to cure because of rising antimicrobial resistance and limited tre..