EMERGING SEVERE MENTAL ILLNESS IN YOUNG PEOPLE
Grant number: 350241
Mental disorders, such as psychotic and severe mood disorders, are the largest cause of disability in Australia. However, there is still little known about illness onset, relapse and progression. We have developed a clinical staging model with transition points from symptomfree to subthreshold status, to threshold disorder to chronic disability. We will investigate neurobiological and psychosocial factors which increase the risk of progression through these stages and use this model as a basis for examining the effectiveness of interventions, for example to prevent, delay or ameliorate onset and relapse, and promote vocational recovery. Thus major clinical and public health benefits and an u..View full description
Related publications (155)
Investigation of structural brain correlates of neurological soft signs in individuals at ultra-high risk for psychosis
Ya Wang, Esmee E Braam, Cassandra MJ Wannan, Tamsyn E Van Rheenen, Raymond CK Chan, Barnaby Nelson, Patrick D McGorry, Alison R Yung, Ashleigh Lin, Warrick J Brewer, John Koutsogiannis, Stephen J Wood, Dennis Velakoulis, Christos Pantelis, Vanessa L Cropley
Increased severity of neurological soft signs (NSS) in schizophrenia have been associated with abnormal brain morphology in cerebe..
Toxoplasma gondii, Herpesviridae and long-term risk of transition to first-episode psychosis in an ultra high-risk sample.
E Burkhardt, M Berger, RH Yolken, A Lin, HP Yuen, SJ Wood, SM Francey, A Thompson, PD McGorry, B Nelson, AR Yung, GP Amminger
BACKGROUND: Ultra high-risk (UHR) criteria were introduced to identify people at imminent risk of developing psychosis. To improve..
The long-term associations between parental behaviors, cognitive function and brain activation in adolescence
Orwa Dandash, Nicolas Cherbuin, Orli Schwartz, Nicholas B Allen, Sarah Whittle
Parenting behavior has a vital role in the development of the brain and cognitive abilities of offspring throughout childhood and ..
Unraveling the Consequences of Childhood Maltreatment: Deviations From Typical Functional Neurodevelopment Mediate the Relationship Between Maltreatment History and Depressive Symptoms
Divyangana Rakesh, Clare Kelly, Nandita Vijayakumar, Andrew Zalesky, Nicholas B Allen, Sarah Whittle
BACKGROUND: Childhood maltreatment is associated with lifelong psychiatric sequelae. However, our understanding of neurobiological..
Associations between early life stress and anterior pituitary gland volume development - A novel index of long-term hypothalamic-pituitary-adrenal axis functioning
Carmela Diaz-Arteche, Julian G Simmons, Despina E Ganella, Orli Schwartz, Jee Hyun Kim, Paige Farrow, Sarah Whittle
Previous research has established associations between early life stress (ELS) and altered pituitary gland volume (PGV) growth dur..
Has improved treatment contributed to the declining rate of transition to psychosis in ultra-high-risk cohorts?
MJC Formica, LJ Phillips, JA Hartmann, AR Yung, SJ Wood, A Lin, GP Amminger, PD McGorry, B Nelson
BACKGROUND: The factors contributing to declining psychotic disorder transition rates in ultra-high-risk populations remain unclea..
Longitudinal Cognitive Performance in Individuals at Ultrahigh Risk for Psychosis: A 10-year Follow-up
Kelly Allott, Stephen J Wood, Hok Pan Yuen, Alison R Yung, Barnaby Nelson, Warrick J Brewer, Daniela Spiliotacopoulos, Annie Bruxner, Magenta Simmons, Christina Broussard, Sumudu Mallawaarachchi, Christos Pantelis, Patrick D McGorry, Ashleigh Lin
It remains unclear whether the onset of psychosis is associated with deterioration in cognitive performance. The aim of this study..
Stability of retrospective self-reports of childhood trauma in first-episode psychosis
Samantha Simpson, Lisa Phillips, Gennady Baksheev, Belinda Garner, Connie Markulev, Christina Phassouliotis, Mario Alvarez-Jimenez, Patrick McGorry, Sarah Bendall
AIM: Childhood trauma (CT), abuse and neglect are commonly reported by individuals experiencing psychosis. However, there are conc..
Early Adolescent Drinking and Cannabis Use Predicts Later Sleep-Quality Problems
Rowan P Ogeil, Ali Cheetham, Anna Mooney, Nicholas B Allen, Orli Schwartz, Michelle L Byrne, Julian G Simmons, Sarah Whittle, Dan Lubman
A range of biopsychosocial changes occur during adolescence that contribute to changes in the sleep-wake system. Use of alcohol an..
Brain-derived neurotrophic factor DNA methylation mediates the association between neighborhood disadvantage and adolescent brain structure
Jo Wrigglesworth, Joanne Ryan, Nandita Vijayakumar, Sarah Whittle
Prior research indicates that socioeconomic disadvantage is associated with prefrontal cortical (PFC) development in childhood and..
Childhood maltreatment, pituitary volume and adolescent hypothalamic-pituitary-adrenal axis -Evidence for a maltreatment-related attenuation
Michael Kaess, Sarah Whittle, Laurie O'Brien-Simpson, Nicholas B Allen, Julian G Simmons
BACKGROUND: Alterations of the development of the hypothalamic-pituitary-adrenal axis (HPAA) have been suggested to be related to ..
Family meta-emotion and the onset of major depressive disorder in adolescence: A prospective longitudinal study
Orli S Schwartz, Vanessa J Rowell, Sarah Whittle, Michelle L Byrne, Julian G Simmons, Lisa Sheeber, Vicki McKenzie, Nicholas B Allen
Meta-emotion philosophy refers to an organized set of thoughts, reactions, and feelings about one's emotions and the emotions of o..
Amygdala volume mediates the relationship between externalizing symptoms and daily smoking in adolescence: A prospective study
Ali Cheetham, Nicholas B Allen, Sarah Whittle, Julian Simmons, Murat Yucel, Dan Lubman
The current study examined amygdala and orbitofrontal cortex (OFC) volumes as mediators of the relationship between externalizing ..
Development of subcortical volumes across adolescence in males and females: A multisample study of longitudinal changes
Megan M Herting, Cory Johnson, Kathryn L Mills, Nandita Vijayakumar, Meg Dennison, Chang Liu, Anne-Lise Goddings, Ronald E Dahl, Elizabeth R Sowell, Sarah Whittle, Nicholas B Allen, Christian K Tamnes
The developmental patterns of subcortical brain volumes in males and females observed in previous studies have been inconsistent. ..
The Ultra-High-Risk for psychosis groups: Evidence to maintain the status quo
MJ McHugh, PD McGorry, HP Yuen, IB Hickie, A Thompson, L de Haan, N Mossaheb, S Smesny, A Lin, C Markulev, M Schloegelhofer, SJ Wood, D Nieman, JA Hartmann, M Nordentoft, M Schafer, GP Amminger, A Yung, B Nelson
Individuals are considered Ultra-High-Risk (UHR) for psychosis if they meet a set of standardised criteria including presumed gene..
Duration of Breastfeeding and Subsequent Adolescent Obesity: Effects of Maternal Behavior and Socioeconomic Status
Michelle L Byrne, Orli S Schwartz, Julian G Simmons, Lisa Sheeber, Sarah Whittle, Nicholas B Allen
PURPOSE: Previous research has shown that longer duration of breastfeeding is associated with less risk of obesity in childhood an..
Adolescent temperament dimensions as stable prospective risk and protective factors for salivary C-reactive protein
Benjamin W Nelson, Michelle L Byrne, Julian G Simmons, Sarah Whittle, Orli S Schwartz, Neil M O'Brien-Simpson, Katrina A Walsh, Eric C Reynolds, Nicholas B Allen
OBJECTIVE: Temperament has associations with later physical health outcomes, yet there is a dearth of research exploring the conne..
Deterioration of visuospatial associative memory following a first psychotic episode: a long-term follow-up study
CMJ Wannan, CF Bartholomeusz, VL Cropley, TE Van Rheenen, A Panayiotou, WJ Brewer, TM Proffitt, L Henry, MG Harris, D Velakoulis, P McGorry, C Pantelis, SJ Wood
BACKGROUND: Cognitive deficits are a core feature of schizophrenia, and impairments in most domains are thought to be stable over ..
Ventricular volumes across stages of schizophrenia and other psychoses
Gregor E Berger, Cali F Bartholomeusz, Stephen J Wood, Anthony Ang, Lisa J Phillips, Tina Proffitt, Warrick J Brewer, Deidre J Smith, Barnaby Nelson, Ashleigh Lin, Stefan Borgwardt, Dennis Velakoulis, Alison R Yung, Patrick D McGorry, Christos Pantelis
OBJECTIVE: Ventricular enlargement is common in established schizophrenia; however, data from ultra high-risk for psychosis and fi..
Longitudinal Bi-directional Effects of Disordered Eating, Depression and Anxiety
Francis Puccio, Matthew Fuller-Tyszkiewicz, George Youssef, Sarah Mitchell, Michelle Byrne, Nick Allen, Isabel Krug
OBJECTIVE: The present study aims to explore the potentially longitudinal bi-directional effects of disordered eating (DE) symptom..
Cortico-amygdalar maturational coupling is associated with depressive symptom trajectories during adolescence
Nandita Vijayakumar, Nicholas B Allen, Meg Dennison, Michelle L Byrne, Julian G Simmons, Sarah Whittle
BACKGROUND: Adolescence is characterized by increasing prevalence of depressive symptomatology, along with significant structural ..
Longitudinal Trajectories of Depression Symptoms in Adolescence: Psychosocial Risk Factors and Outcomes
Rachel ER Ellis, Marc L Seal, Julian G Simmons, Sarah Whittle, Orli S Schwartz, Michelle L Byrne, Nicholas B Allen
Variations in symptom trajectories within a population may represent distinct groups with different etiologies and outcomes. This ..
Role of Positive Parenting in the Association Between Neighborhood Social Disadvantage and Brain Development Across Adolescence
Sarah Whittle, Nandita Vijayakumar, Julian G Simmons, Meg Dennison, Orli Schwartz, Christos Pantelis, Lisa Sheeber, Michelle L Byrne, Nicholas B Allen
Importance: The negative effects of socioeconomic disadvantage on lifelong functioning are pronounced, with some evidence suggesti..
Physiological correlates of emotional reactivity and regulation in early adolescents
Melissa D Latham, Nina Cook, Julian G Simmons, Michelle L Byrne, Jonathan WL Kettle, Orli Schwartz, Nandita Vijayakumar, Sarah Whittle, Nicholas B Allen
Few studies have examined physiological correlates of emotional reactivity and regulation in adolescents, despite the occurrence i..
Affective Parenting Behaviors, Adolescent Depression, and Brain Development: A Review of Findings From the Orygen Adolescent Development Study
Orli S Schwartz, Julian G Simmons, Sarah Whittle, Michelle L Byrne, Marie BH Yap, Lisa B Sheeber, Nicholas B Allen
Parenting plays a multifaceted role in adolescent development. In this article, we review studies based on an observational assess..
Long-term employment among people at ultra-high risk for psychosis
Jack Cotter, Ashleigh Lin, Richard J Drake, Andrew Thompson, Barnaby Nelson, Patrick McGorry, Stephen J Wood, Alison R Yung
BACKGROUND: Psychotic disorders are associated with high rates of sustained unemployment, however, little is known about the long-..
Using clinical information to make individualized prognostic predictions in people at ultra high risk for psychosis
Andrea Mechelli, Ashleigh Lin, Stephen Wood, Patrick McGorry, Paul Amminger, Stefania Tognin, Philip McGuire, Jonathan Young, Barnaby Nelson, Alison Yung
Recent studies have reported an association between psychopathology and subsequent clinical and functional outcomes in people at u..
Cannabis-induced attenuated psychotic symptoms: implications for prognosis in young people at ultra-high risk for psychosis
MJ McHugh, PD McGorry, AR Yung, A Lin, SJ Wood, JA Hartmann, B Nelson
BACKGROUND: Cannabis use shows a robust dose-dependent relationship with psychosis risk among the general population. Despite this..
Lithium suppression of tau induces brain iron accumulation and neurodegeneration
P Lei, S Ayton, AT Appukuttan, S Moon, JA Duce, I Volitakis, R Cherny, SJ Wood, M Greenough, G Berger, C Pantelis, P McGorry, A Yung, DI Finkelstein, AI Bush
Lithium is a first-line therapy for bipolar affective disorder. However, various adverse effects, including a Parkinson-like hand ..
Substance use in youth at risk for psychosis
R Carney, AR Yung, GP Amminger, T Bradshaw, N Glozier, DF Hermens, IB Hickie, E Killackey, P McGorry, C Pantelis, SJ Wood, R Purcell
BACKGROUND: People with schizophrenia have high rates of substance use which contributes to co-morbidity and premature mortality. ..
Brain connectivity networks and longitudinal trajectories of depression symptoms in adolescence
Rachel Ellis, Marc L Seal, Christopher Adamson, Richard Beare, Julian G Simmons, Sarah Whittle, Nicholas B Allen
High levels of depression during adolescence may contribute to the risk for future depression later in life. This study examined t..
Childhood maltreatment, psychopathology, and the development of hippocampal subregions during adolescence
Sarah Whittle, Julian G Simmons, Sylke Hendriksma, Nandita Vijayakumar, Michelle L Byrne, Meg Dennison, Nicholas B Allen
INTRODUCTION: It is well established that childhood maltreatment has a detrimental impact on the brain, particularly the hippocamp..
Multi-center MRI prediction models: Predicting sex and illness course in first episode psychosis patients
Mireille Nieuwenhuis, Hugo G Schnack, Neeltje E van Haren, Julia Lappin, Craig Morgan, Antje A Reinders, Diana Gutierrez-Tordesillas, Roberto Roiz-Santianez, Maristela S Schaufelberger, Pedro G Rosa, Marcus V Zanetti, Geraldo F Busatto, Benedicto Crespo-Facorro, Patrick D McGorry, Dennis Velakoulis, Christos Pantelis, Stephen J Wood, Rene S Kahn, Janaina Mourao-Miranda, Paola Dazzan
Structural Magnetic Resonance Imaging (MRI) studies have attempted to use brain measures obtained at the first-episode of psychosi..
Further examination of the reducing transition rate in ultra high risk for psychosis samples: The possible role of earlier intervention
B Nelson, HP Yuen, A Lin, SJ Wood, PD McGorry, JA Hartmann, AR Yung
BACKGROUND: The rate of transition to psychotic disorder in ultra high risk (UHR) patients has declined in recent cohorts. The rea..
Trajectories of adolescent conduct problems in relation to cortical thickness development: a longitudinal MRI study
S Oostermeijer, S Whittle, C Suo, NB Allen, JG Simmons, N Vijayakumar, PM van de Ven, LMC Jansen, M Yucel, A Popma
Multiple cross-sectional imaging studies have identified structural abnormalities in prefrontal, temporal and limbic regions relat..
Baseline grey matter volume of non-transitioned "ultra high risk" for psychosis individuals with and without attenuated psychotic symptoms at long-term follow-up
Vanessa L Cropley, Ashleigh Lin, Barnaby Nelson, Renate LEP Reniers, Alison R Yung, Cali F Bartholomeusz, Paul Klauser, Dennis Velakoulis, Patrick McGorry, Stephen J Wood, Christos Pantelis
Brain Development During Adolescence: A Mixed-Longitudinal Investigation of Cortical Thickness, Surface Area, and Volume
Nandita Vijayakumar, Nicholas B Allen, George Youssef, Meg Dennison, Murat Yucel, Julian G Simmons, Sarah Whittle
What we know about cortical development during adolescence largely stems from analyses of cross-sectional or cohort-sequential sam..
Observed Measures of Negative Parenting Predict Brain Development during Adolescence
Sarah Whittle, Nandita Vijayakumar, Meg Dennison, Orli Schwartz, Julian G Simmons, Lisa Sheeber, Nicholas B Allen
Limited attention has been directed toward the influence of non-abusive parenting behaviour on brain structure in adolescents. It ..
Declining transition rates to psychotic disorder in "ultra-high risk" clients: Investigation of a dilution effect
Jessica A Hartmann, Hok Pan Yuen, Patrick D McGorry, Alison R Yung, Ashleigh Lin, Stephen J Wood, Suzie Lavoie, Barnaby Nelson
During recent years, a decrease has been noted in the rate of transition of ultra-high risk (UHR) clients to a psychotic disorder...
Childhood maltreatment and transition to psychotic disorder independently predict long-term functioning in young people at ultra-high risk for psychosis
AR Yung, J Cotter, SJ Wood, P McGorry, AD Thompson, B Nelson, A Lin
BACKGROUND: Individuals identified as at ultra-high risk (UHR) for psychosis are at risk of poor functional outcome regardless of ..
Neighbourhood characteristics and the rate of identification of young people at ultra-high risk for psychosis
Brian O'Donoghue, Alison R Yung, Stephen Wood, Andrew Thompson, Ashleigh Lin, Patrick McGorry, Barnaby Nelson
There is a higher incidence of psychotic disorders in more socially deprived neighbourhoods and a higher risk in migrants living i..
Effects of oxytocin and genetic variants on brain and behaviour: Implications for treatment in schizophrenia
Cali F Bartholomeusz, Eleni P Ganella, Izelle Labuschagne, Chad Bousman, Christos Pantelis
Impairments in social cognition and poor social functioning are core features of schizophrenia-spectrum disorders. In recent years..
Linking the Serotonin Transporter Gene, Family Environments, Hippocampal Volume and Depression Onset: A Prospective Imaging Gene X Environment Analysis
Keriann Little, Craig A Olsson, George J Youssef, Sarah Whittle, Julian G Simmons, Murat Yuecel, Lisa B Sheeber, Debra L Foley, Nicholas B Allen
A single imaging gene-environment (IGxE) framework that is able to simultaneously model genetic, neurobiological, and environmenta..
Dual-Axis Hormonal Covariation in Adolescence and the Moderating Influence of Prior Trauma and Aversive Maternal Parenting
Julian G Simmons, Michelle L Byrne, Orli S Schwartz, Sarah L Whittle, Lisa Sheeber, Michael Kaess, George J Youssef, Nicholas B Allen
Adversity early in life can disrupt the functioning of the hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes ..
Cognitive intervention in early psychosis - preserving abilities versus remediating deficits
Christos Pantelis, Cassandra Wannan, Cali F Bartholomeusz, Kelly Allott, Patrick D McGorry
Remediation strategies have focused on a deficits model to plan restorative interventions, with inconsistent results. Here, we pro..
Dispositional mindfulness is predicted by structural development of the insula during late adolescence
S Friedel, SL Whittle, N Vijayakumar, JG Simmons, ML Byrne, OS Schwartz, NB Allen
Adolescence is a critical period of development, in which the increasing social and cognitive demands of independence need to be m..
Declining transition rates to psychosis: the contribution of potential changes in referral pathways to an ultra-high-risk service
Suzanne Wiltink, Eva Velthorst, Barnaby Nelson, Patrick M McGorry, Alison R Yung
AIM: On the basis of applying 'ultra-high-risk' (UHR) criteria, initially high rates of transition to psychosis were reported. How..
Discrete Alterations of Brain Network Structural Covariance in Individuals at Ultra-High Risk for Psychosis
Kareen Heinze, Renate LEP Reniers, Barnaby Nelson, Alison R Yung, Ashleigh Lin, Ben J Harrison, Christos Pantelis, Dennis Velakoulis, Patrick D McGorry, Stephen J Wood
BACKGROUND: Investigation of aberrant large-scale brain networks offers novel insight into the role these networks play in diverse..
Attention to pleasant stimuli in early adolescence predicts alcohol-related problems in mid-adolescence
Joshua BB Garfield, Nicholas B Allen, Ali Cheetham, Julian G Simmons, Dan I Lubman
Attenuated responses to natural rewards have been found to predict subsequent substance use among dependent populations, suggestin..
Social Functioning Trajectories of Young First-Episode Psychosis Patients with and without Cannabis Misuse: A 30-Month Follow-Up Study
Cesar Gonzalez-Blanch, John F Gleeson, Peter Koval, Sue M Cotton, Patrick D McGorry, Mario Alvarez-Jimenez
The aim of the study was to investigate trajectories of social functioning in young people with first-episode psychosis (FEP) with..
Functional brain-imaging correlates of negative affectivity and the onset of first-episode depression
CG Davey, S Whittle, BJ Harrison, JG Simmons, ML Byrne, OS Schwartz, NB Allen
BACKGROUND: The amygdala and subgenual anterior cingulate cortex (sACC) are key brain regions for the generation of negative affec..
The influence of sex, temperament, risk-taking and mental health on the emergence of gambling: a longitudinal study of young people
Murat Yuecel, Sarah Whittle, George J Youssef, Himani Kashyap, Julian G Simmons, Orli Schwartz, Dan I Lubman, Nicholas B Allen
There are a host of complex and interlinked psychological, social and biological factors involved in the development of problem ga..
Early life stress alters pituitary growth during adolescence-A longitudinal study
Despina E Ganella, Nicholas B Allen, Julian G Simmons, Orli Schwartz, Jee Hyun Kim, Lisa Sheeber, Sarah Whittle
The pituitary gland is integral in mediating the stress-response via its role in hypothalamic-pituitary-adrenal (HPA) axis functio..
Outcomes of Nontransitioned Cases in a Sample at Ultra-High Risk for Psychosis
Ashleigh Lin, Stephen J Wood, Barnaby Nelson, Amanda Beavan, Patrick McGorry, Alison R Yung
OBJECTIVE: Two-thirds of individuals identified as at ultra-high risk for psychosis do not develop psychotic disorder over the med..
Trait positive affect is associated with hippocampal volume and change in caudate volume across adolescence
Meg Dennison, Sarah Whittle, Murat Yuecel, Michelle L Byrne, Orli Schwartz, Julian G Simmons, Nicholas B Allen
Trait positive affect (PA) in childhood confers both risk and resilience to psychological and behavioral difficulties in adolescen..
The relationship between stress, HPA axis functioning and brain structure in first episode psychosis over the first 12 weeks of treatment
Renate LEP Reniers, Belinda Garner, Christina Phassouliotis, Lisa J Phillips, Connie Markulev, Christos Pantelis, Sarah Bendall, Patrick D McGorry, Stephen J Wood
Stress and abnormal hypothalamic-pituitary-adrenal axis functioning have been implicated in the early phase of psychosis and may p..
Olfactory identification deficits at identification as ultra-high risk for psychosis are associated with poor functional outcome
A Lin, WJ Brewer, AR Yung, B Nelson, C Pantelis, SJ Wood
BACKGROUND: We have previously reported that olfactory identification (OI) deficits are a promising premorbid marker of transition..
Longitudinal relationship between expressed emotion and cannabis misuse in young people with first-episode psychosis
C Gonzalez-Blanch, JF Gleeson, SM Cotton, K Crisp, PD McGorry, M Alvarez-Jimenez
Carers' expressed emotion (EE) and patients' cannabis misuse are two of the most robust predictors of psychotic relapse. We aimed ..
Social environmental risk factors for transition to psychosis in an ultra-high risk (UHR) population
Brian O'Donoghue, Barnaby Nelson, Hok Pan Yuen, Abbie Lane, Stephen Wood, Andrew Thompson, Ashleigh Lin, Patrick McGorry, Alison Yung
OBJECTIVE: Despite social environmental factors such as deprivation, urbanicity, migration and adversity being established risk fa..
Thinning of the lateral prefrontal cortex during adolescence predicts emotion regulation in females
Nandita Vijayakumar, Sarah Whittle, Murat Yuecel, Meg Dennison, Julian Simmons, Nicholas B Allen
Adolescence is a crucial period for the development of adaptive emotion regulation strategies. Despite the fact that structural ma..
Long-term follow-up of all-cause and unnatural death in young people with first-episode psychosis
Kally Yuen, Susy M Harrigan, Andrew J Mackinnon, Meredith G Harris, Hok Pan Yuen, Lisa P Henry, Henry J Jackson, Helen Herrman, Patrick D McGorry
OBJECTIVE: To determine mortality-related estimates and causes of death in young people with first-episode psychosis (FEP), and to..
Association between serotonin transporter genotype, brain structure and adolescent-onset major depressive disorder: a longitudinal prospective study
K Little, CA Olsson, S Whittle, GJ Youssef, ML Byrne, JG Simmons, M Yuecel, DL Foley, NB Allen
The extent to which brain structural abnormalities might serve as neurobiological endophenotypes that mediate the link between the..
Development of temperamental effortful control mediates the relationship between maturation of the prefrontal cortex and psychopathology during adolescence: A 4-year longitudinal study
Nandita Vijayakumar, Sarah Whittle, Meg Dennison, Murat Yuecel, Julian Simmons, Nicholas B Allen
This study investigated the relationship between the development of effortful control (EC), a temperamental measure of self-regula..
Positive parenting predicts the development of adolescent brain structure: A longitudinal study
Sarah Whittle, Julian G Simmons, Meg Dennison, Nandita Vijayakumar, Orli Schwartz, Marie BH Yap, Lisa Sheeber, Nicholas B Allen
Little work has been conducted that examines the effects of positive environmental experiences on brain development to date. The a..
Altered depth of the olfactory sulcus in ultra high-risk individuals and patients with psychotic disorders
Tsutomu Takahashi, Stephen J Wood, Alison R Yung, Barnaby Nelson, Ashleigh Lin, Murat Yuecel, Lisa J Phillips, Yumiko Nakamura, Michio Suzuki, Warrick J Brewer, Tina M Proffitt, Patrick D McGorry, Dennis Velakoulis, Christos Pantelis
A shallow olfactory sulcus has been reported in schizophrenia, possibly reflecting abnormal forebrain development during early ges..
Reduced parahippocampal cortical thickness in subjects at ultra-high risk for psychosis
S Tognin, A Riecher-Roessler, EM Meisenzahl, SJ Wood, C Hutton, SJ Borgwardt, N Koutsouleris, AR Yung, P Allen, LJ Phillips, PD McGorry, I Valli, D Velakoulis, B Nelson, J Woolley, C Pantelis, P McGuire, A Mechelli
BACKGROUND: Grey matter volume and cortical thickness represent two complementary aspects of brain structure. Several studies have..
Neurocognitive predictors of transition to psychosis: medium- to long-term findings from a sample at ultra-high risk for psychosis
A Lin, AR Yung, B Nelson, WJ Brewer, R Riley, M Simmons, C Pantelis, SJ Wood
BACKGROUND: Individuals at ultra-high risk (UHR) for psychosis show reduced neurocognitive performance across domains but it is un..
Sex-specific prediction of hypothalamic-pituitary-adrenal axis activity by pituitary volume during adolescence: A longitudinal study from 12 to 17 years of age
Michael Kaess, Julian G Simmons, Sarah Whittle, Martina Jovev, Andrew M Chanen, Murat Yuecel, Christos Pantelis, Nicholas B Allen
OBJECTIVE: To investigate the longitudinal relationship between pituitary gland volume (PGV) and parameters of hypothalamic-pituit..
Mapping subcortical brain maturation during adolescence: evidence of hemisphere- and sex-specific longitudinal changes
Meg Dennison, Sarah Whittle, Murat Yuecel, Nandita Vijayakumar, Alexandria Kline, Julian Simmons, Nicholas B Allen
Early to mid-adolescence is an important developmental period for subcortical brain maturation, but longitudinal studies of these ..
Long-term Follow-up of a Group at Ultra High Risk ("Prodromal") for Psychosis The PACE 400 Study
Barnaby Nelson, Hok Pan Yuen, Stephen J Wood, Ashleigh Lin, Daniela Spiliotacopoulos, Annie Bruxner, Christina Broussard, Magenta Simmons, Debra L Foley, Warrick J Brewer, Shona M Francey, G Paul Amminger, Andrew Thompson, Patrick D McGorry, Alison R Yung
IMPORTANCE: The ultra high-risk (UHR) criteria were introduced to prospectively identify patients at high risk of psychotic disord..
Sulcogyral patterns and morphological abnormalities of the orbitofrontal cortex in psychosis
Cali F Bartholomeusz, Sarah L Whittle, Alice Montague, Brendan Ansell, Patrick D McGorry, Dennis Velakoulis, Christos Pantelis, Stephen J Wood
Three types of OFC sulcogyral patterns have been identified in the general population. The distribution of these three types has b..
Maternal Parenting Behaviors and Adolescent Depression: The Mediating Role of Rumination
Michael A Gate, Edward R Watkins, Julian G Simmons, Michelle L Byrne, Orli S Schwartz, Sarah Whittle, Lisa B Sheeber, Nicholas B Allen
Substantial evidence suggests that rumination is an important vulnerability factor for adolescent depression. Despite this, few st..
Enhanced cortisol suppression following administration of low-dose dexamethasone in first-episode psychosis patients
Christina Phassouliotis, Belinda A Garner, Lisa J Phillips, Sarah Bendall, Yang Yun, Connie Markulev, Melissa Kerr, Patrick D McGorry
OBJECTIVE: Impaired regulation of the hypothalamic-pituitary-adrenal (HPA) axis and hyper-activity of this system have been descri..
A Randomized Controlled Trial of Relapse Prevention Therapy for First-Episode Psychosis Patients: Outcome at 30-Month Follow-Up
John FM Gleeson, Sue M Cotton, Mario Alvarez-Jimenez, Darryl Wade, Donna Gee, Kingsley Crisp, Tracey Pearce, Daniela Spiliotacopoulos, Belinda Newman, Patrick D McGorry
The effectiveness of a novel 7-month psychosocial treatment designed to prevent the second episode of psychosis was evaluated in a..
Development and Validation of a New Measure of Everyday Adolescent Functioning: The Multidimensional Adolescent Functioning Scale
Klaas J Wardenaar, Johanna TW Wigman, Ashleigh Lin, Eoin Killackey, Dina Collip, Stephen J Wood, Jaymee Ryan, Gennady Baksheev, Elizabeth Cosgrave, Barnaby Nelson, Alison R Yung
PURPOSE: Everyday functioning is an important outcome for studies of the developmental psychopathology of adolescence. An unbiased..
Clinical Neuropsychology Within Adolescent and Young-Adult Psychiatry: Conceptualizing Theory and Practice
Kelly Allott, Tina-Marie Proffitt, Patrick D McGorry, Christos Pantelis, Stephen J Wood, Marnie Cumner, Warrick J Brewer
Historically, clinical neuropsychology has made significant contributions to the understanding of brain-behavior relationships, pa..
Predictors of Vocational Recovery Among Young People With First-Episode Psychosis: Findings From a Randomized Controlled Trial
Gennady N Baksheev, Kelly Allott, Henry J Jackson, Patrick D McGorry, Eoin Killackey
OBJECTIVE: The current study sought to examine demographic and clinical predictors of vocational recovery among young people with ..
Volumetric Abnormalities Predating the Onset of Schizophrenia and Affective Psychoses: An MRI Study in Subjects at Ultrahigh Risk of Psychosis
Paola Dazzan, Bridget Soulsby, Andrea Mechelli, Stephen J Wood, Dennis Velakoulis, Lisa J Phillips, Alison R Yung, Xavier Chitnis, Ashleigh Lin, Robin M Murray, Patrick D McGorry, Philip K McGuire, Christos Pantelis
It remains unclear whether brain structural abnormalities observed before the onset of psychosis are specific to schizophrenia or ..
Phenylthiocarbamide (PTC) perception in ultra-high risk for psychosis participants who develop schizophrenia: Testing the evidence for an endophenotypic marker
Warrick J Brewer, Ashleigh Lin, Paul J Moberg, Gregory Smutzer, Barnaby Nelson, Alison R Yung, Christos Pantelis, Patrick D McGorry, Bruce I Turetsky, Stephen J Wood
Reports suggesting that schizophrenia participants are more likely to be phenylthiocarbamide (PTC) non-tasters when compared to co..
Orbitofrontal Volumes in Early Adolescence Predict Initiation of Cannabis Use: A 4-Year Longitudinal and Prospective Study
Ali Cheetham, Nicholas B Allen, Sarah Whittle, Julian G Simmons, Murat Yuecel, Dan I Lubman
BACKGROUND: There is growing evidence that long-term, heavy cannabis use is associated with alterations in regional brain volumes...
Emotional Inertia Prospectively Predicts the Onset of Depressive Disorder in Adolescence
Peter Kuppens, Lisa B Sheeber, Marie BH Yap, Sarah Whittle, Julian G Simmons, Nicholas B Allen
Emotional inertia refers to the degree to which a person's current emotional state is predicted by their prior emotional state, re..
Road to full recovery: longitudinal relationship between symptomatic remission and psychosocial recovery in first-episode psychosis over 7.5 years
M Alvarez-Jimenez, JF Gleeson, LP Henry, SM Harrigan, MG Harris, E Killackey, S Bendall, GP Amminger, AR Yung, H Herrman, HJ Jackson, PD McGorry
BACKGROUND: In recent years there has been increasing interest in functional recovery in the early phase of schizophrenia. Concurr..
The Impact of Cannabis Use on Cognitive Functioning in Patients With Schizophrenia: A Meta-analysis of Existing Findings and New Data in a First-Episode Sample
Murat Yuecel, Emre Bora, Dan I Lubman, Nadia Solowij, Warrick J Brewer, Sue M Cotton, Philippe Conus, Michael J Takagi, Alex Fornito, Stephen J Wood, Patrick D McGorry, Christos Pantelis
Cannabis use is highly prevalent among people with schizophrenia, and coupled with impaired cognition, is thought to heighten the ..
Amygdala and insula volumes prior to illness onset in bipolar disorder: A magnetic resonance imaging study
Andreas Bechdolf, Stephen J Wood, Barnaby Nelson, Dennis Velakoulis, Murat Yuecel, Tsutomu Takahashi, Alison R Yung, Michael Berk, Michael T Wong, Christos Pantelis, Patrick D McGorry
There are now numerous reports of neuroanatomical abnormalities in people with bipolar disorder. However, it remains unclear wheth..
The relationship between coping and subclinical psychotic experiences in adolescents from the general population - a longitudinal study
A Lin, JTW Wigman, B Nelson, WAM Vollebergh, J van Os, G Baksheev, J Ryan, QAW Raaijmakers, A Thompson, AR Yung
BACKGROUND: Subclinical psychotic experiences during adolescence may represent liability for developing psychotic disorder. Both c..
Neuroimaging and Treatment Evidence for Clinical Staging in Psychotic Disorders: From the At-Risk Mental State to Chronic Schizophrenia
Stephen J Wood, Alison R Yung, Patrick D McGorry, Christos Pantelis
A new approach to understanding severe mental disorders such as schizophrenia is to adopt a clinical staging model. Such a model d..
Observed maternal responses to adolescent behaviour predict the onset of major depression
Orli S Schwartz, Paul Dudgeon, Lisa B Sheeber, Marie BH Yap, Julian G Simmons, Nicholas B Allen
Two mechanisms have been proposed regarding relations between parental responses to adolescent affective behaviours and the develo..
Preventing the Second Episode: A Systematic Review and Meta-analysis of Psychosocial and Pharmacological Trials in First-Episode psychosis
Mario Alvarez-Jimenez, Alexandra G Parker, Sarah E Hetrick, Patrick D McGorry, John F Gleeson
OBJECTIVE: The majority of first-episode psychosis (FEP) patients reach clinical remission; however, rates of relapse are high. Th..
Pituitary volume prospectively predicts internalizing symptoms in adolescence
Amy R Zipursky, Sarah Whittle, Murat Yuecel, Valentina Lorenzetti, Stephen J Wood, Dan I Lubman, Julian G Simmons, Nicholas B Allen
BACKGROUND: Early adolescence is a critical time for the development of both internalizing and externalizing disorders. We aimed t..
Referrers' Perceived Utility and Outcomes of Clinical Neuropsychological Assessment in an Adolescent and Young Adult Public Mental Health Service
Kelly Allott, Warrick Brewer, Patrick D McGorry, Tina-Marie Proffitt
Despite frequent informal or anecdotal acknowledgement of the usefulness of neuropsychological services within various settings, i..
Cortisol and dehydroepiandrosterone-sulphate levels correlate with symptom severity in first-episode psychosis
Belinda Garner, Christina Phassouliotis, Lisa J Phillips, Connie Markulev, Felicity Butselaar, Sarah Bendall, Yang Yun, Patrick D McGorry
BACKGROUND: Dehydroepiandrosterone (DHEA) and its sulphate form (DHEA) are neuroactive steroids with antiglucocorticoid properties..
Prediction of a single psychotic episode: A 7.5-year, prospective study in first-episode psychosis
M Alvarez-Jimenez, JF Gleeson, LP Henry, SM Harrigan, MG Harris, GP Amminger, E Killackey, AR Yung, H Herrman, HJ Jackson, PD McGorry
BACKGROUND: Around 20% of patients who suffer from psychosis will experience a single psychotic episode (SPE), but relatively litt..
Assessing oxidative pathway genes as risk factors for bipolar disorder
Janice M Fullerton, Yash Tiwari, Giti Agahi, Anna Heath, Michael Berk, Philip B Mitchell, Peter R Schofield
OBJECTIVES: There is a growing body of evidence implicating oxidative stress and the glutathione system in the pathogenesis of maj..
Caudate nucleus volume in individuals at ultra-high risk of psychosis: A cross-sectional magnetic resonance imaging study
Katrina L Hannan, Stephen J Wood, Alison R Yung, Dennis Velakoulis, Lisa J Phillips, Bridget Soulsby, Gregor Berger, Patrick D McGorry, Christos Pantelis
The aim of the present study was to investigate whether volumetric abnormalities of the caudate nuclei predate the onset of psycho..
Neuroprotective effects of ethyl-eicosapentaenoic acid in first episode psychosis: A longitudinal T-2 relaxometry pilot study
Stephen J Wood, Luca Cocchi, Tina-Marie Proffitt, Mirabel McConchie, Graeme D Jackson, Tsutomu Takahashi, Christos Pantelis, Patrick D McGorry, Gregor E Berger
We used magnetic resonance imaging to examine the effect of ethyl-eicosapentaenoic acid (E-EPA) on hippocampal T(2) relaxation tim..
OLFACTORY SENSITIVITY: FUNCTIONING IN SCHIZOPHRENIA AND IMPLICATIONS FOR UNDERSTANDING THE NATURE AND PROGRESSION OF PSYCHOSIS
Warrick J Brewer, Christos Pantelis
Prefrontal neural processes maturing during neurodevelopment parallel normal improvement in higher order olfactory processing (ide..
Suicide attempt in first-episode psychosis: A 7.4 year follow-up study
J Robinson, MG Harris, SM Harrigan, LP Henry, S Farrelly, A Prosser, O Schwartz, H Jackson, PD McGorry
BACKGROUND: Individuals with first-episode psychosis demonstrate high rates of suicide attempt (SA). AIMS: 1) To examine the preva..
The effect of atypical antipsychotics on pituitary gland volume in patients with first-episode psychosis: A longitudinal MRI study
John-Paul Nicolo, Gregor E Berger, Belinda A Garner, Dennis Velakoulis, Connie Markulev, Melissa Kerr, Patrick D McGorry, Tina-Marie Proffitt, Mirabel McConchie, Christos Pantelis, Stephen J Wood
Grey and white matter abnormalities are associated with impaired spatial working memory ability in first-episode schizophrenia
Luca Cocchi, Mark Walterfang, Renee Testa, Stephen J Wood, Marc L Seal, John Suckling, Tsutomu Takahashi, Tina-Marie Proffitt, Warrick J Brewer, Christopher Adamson, Bridget Soulsby, Dennis Velakoulis, Patrick D McGorry, Christos Pantelis
Spatial working memory (SWM) dysfunction has been suggested as a trait marker of schizophrenia and implicates a diffuse network in..
Brain surface contraction mapped in first-episode schizophrenia: a longitudinal magnetic resonance imaging study
D Sun, GW Stuart, M Jenkinson, SJ Wood, PD McGorry, D Velakoulis, TGM van Erp, PM Thompson, AW Toga, DJ Smith, TD Cannon, C Pantelis
Schizophrenia is associated with structural brain abnormalities, but the timing of onset and course of these changes remains uncle..
The reliability and validity of the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) in first-episode psychosis
Leanne Hides, Sue M Cotton, Gregor Berger, John Gleeson, Colin O'Donnell, Tina Proffitt, Patrick D McGorry, Dan I Lubman
AIMS: The Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) is a brief, easily administered, valid and reliable s..
Maternal responses to adolescent positive affect are associated with adolescents' reward neuroanatomy
Sarah Whittle, Marie BH Yap, Murat Yuecel, Lisa Sheeber, Julian G Simmons, Christos Pantelis, Nicholas B Allen
The development of reward-based learning and decision-making, and the neural circuitry underlying these processes, appears to be i..
Structural brain abnormalities in major depressive disorder: A selective review of recent MRI studies
Valentina Lorenzetti, Nicholas B Allen, Alex Fornito, Murat Yuecel
BACKGROUND: While there is evidence to suggest that major depressive disorder (MDD) is associated with structural brain abnormalit..
Corpus callosum size and shape in first-episode affective and schizophrenia-spectrum psychosis
Mark Walterfang, Amanda G Wood, David C Reutens, Stephen J Wood, Jian Chen, Dennis Velakoulis, Patrick D McGorry, Christos Pantelis
Reductions in the size of the anterior callosum have been described for both first-episode and established schizophrenia and bipol..
Attentional set-shifting ability in first-episode and established schizophrenia: Relationship to working memory
Christos Pantelis, Stephen J Wood, Tina M Proffitt, Renee Testa, Kate Mahony, Warrick J Brewer, Jo-Anne Buchanan, Dennis Velakoulis, Patrick D McGorry
Patients with established schizophrenia perform poorly on attentional set-shifting tasks, due to a failure of inhibitory control a..
Influence of the fusiform gyrus on amygdala response to emotional faces in the non-clinical range of social anxiety
J Pujol, BJ Harrison, H Ortiz, J Deus, C Soriano-Mas, M Lopez-Sola, M Yuecel, X Perich, N Cardoner
BACKGROUND: Social anxiety often involves a combination of hypervigilance and avoidance to potentially warning signals including t..
Diagnostic specificity of the insular cortex abnormalities in first-episode psychotic disorders
Tsutomu Takahashi, Stephen J Wood, Bridget Soulsby, Ryoichiro Tanino, Michael TH Wong, Patrick D McGorry, Michio Suzuki, Dennis Velakoulis, Christos Pantelis
Volume reductions of the insular cortex have been described in schizophrenia, but it remains unclear whether other psychotic disor..
A disturbed sense of self in the psychosis prodrome: Linking phenomenology and neurobiology
B Nelson, A Fornito, BJ Harrison, M Yuecel, LA Sass, AR Yung, A Thompson, SJ Wood, C Pantelis, PD McGorry
Interest in the early phase of psychotic disorders has risen dramatically in recent years. Neurobiological investigations have foc..
Anterior cingulate volume in adolescents with first-presentation borderline personality disorder
Sarah Whittle, Andrew M Chanen, Alex Fornito, Patrick D McGorry, Christos Pantelis, Murat Yuecel
Reports of volumetric abnormalities in the anterior cingulate cortex (ACC) in adults with established borderline personality disor..
Pituitary gland volume in currently depressed and remitted depressed patients
Valentina Lorenzetti, Nicholas B Allen, Alex Fornito, Christos Pantelis, Giovanni De Plato, Anthony Ang, Murat Yuecel
Major depressive disorder (MDD) has been associated with increased pituitary gland volume (PGV), which is thought to reflect stres..
Variations in cortical folding patterns are related to individual differences in temperament
Sarah Whittle, Nicholas B Allen, Alex Fornito, Dan I Lubman, Julian G Simmons, Christos Pantelis, Murat Yuecel
There is evidence that anterior cingulate cortex (ACC) function is related to individual differences in temperament. An important ..
Progressive Gray Matter Reduction of the Superior Temporal Gyrus During Transition to Psychosis
Tsutomu Takahashi, Stephen J Wood, Alison R Yung, Bridget Soulsby, Patrick D McGorry, Michio Suzuki, Yasuhiro Kawasaki, Lisa J Phillips, Dennis Velakoulis, Christos Pantelis
CONTEXT: Longitudinal magnetic resonance imaging studies have shown progressive gray matter reduction in the superior temporal gyr..
Medial temporal lobe glutathione concentration in first episode psychosis: A H-1-MRS investigation
Stephen J Wood, Gregor E Berger, R Mark Wellard, Tina-Marie Proffitt, Mirabel McConchie, Michael Berk, Patrick D McGorry, Christos Pantelis
Glutathione (GSH) is implicated in the pathophysiology of schizophrenia. Previous brain spectroscopy studies, however, have been i..
Progressive brain structural changes mapped as psychosis develops in 'at risk' individuals
Daqiang Sun, Lisa Phillips, Dennis Velakoulis, Alison Yung, Patrick D McGorry, Stephen J Wood, Theo GM van Erp, Paul M Thompson, Arthur W Toga, Tyrone D Cannon, Christos Pantelis
BACKGROUND: Schizophrenia and related psychoses are associated with brain structural abnormalities. Recent findings in 'at risk' p..
Brain changes during the onset of schizophrenia: implications for neurodevelopmental theories
Stephen J Wood, Christos Pantelis, Alison R Yung, Dennis Velakoulis, Patrick D McGorry
Neuroimaging studies of individuals at risk of psychosis have the potential to identify markers predictive of illness onset and fe..
Psychotic-like experiences in a community sample of adolescents: implications for the continuum model of psychosis and prediction of schizophrenia
Alison R Yung, Barnaby Nelson, Kathryn Baker, Joe A Buckby, Gennady Baksheev, Elizabeth M Cosgrave
OBJECTIVE: Studies conducted in community samples suggest that psychotic-like experiences are common in the general population, le..
Anatomic Abnormalities of the Anterior Cingulate Cortex Before Psychosis Onset: An MRI Study of Ultra-High-Risk Individuals
Alex Fornito, Alison R Yung, Stephen J Wood, Lisa J Phillips, Barnaby Nelson, Sue Cotton, Dennis Velakoulis, Patrick D McGorry, Christos Pantelis, Murat Yuecel
BACKGROUND: Abnormalities of the anterior cingulate cortex (ACC) are frequently implicated in the pathophysiology of psychotic dis..
Adhesio interthalamica in individuals at high-risk for developing psychosis and patients with psychotic disorders
Tsutomu Takahashi, Murat Yucel, Alison R Yung, Stephen J Wood, Lisa J Phillips, Gregor E Berger, Anthony Ang, Bridget Soulsby, Patrick D McGorry, Michio Suzuki, Dennis Velakoulis, Christos Pantelis
Abnormal neurodevelopment in midline structures such as the adhesio interthalamica (AI) has been reported in psychotic disorders, ..
Maternal Meta-Emotion Philosophy and Socialization of Adolescent Affect: The Moderating Role of Adolescent Temperament
Marie BH Yap, Nicholas B Allen, Craig Leve, Lynn Fainsilber Katz
This study explored the associations between maternal meta-emotion philosophy (MEP) and maternal socialization of preadolescents' ..
Validation of "prodromal" criteria to detect individuals at ultra high risk of psychosis: 2 year follow-up
Alison R Yung, Barnaby Nelson, Carrie Stanford, Magenta B Simmons, Elizabeth M Cosgrave, Eoin Killackey, Lisa J Phillips, Andreas Bechdolf, Joe Buckby, Patrick D McGorry
BACKGROUND: Identification of individuals "prodromal" for schizophrenia and other psychotic disorders relies on criteria that pred..
Ethyl-eicosapentaenoic acid in first-episode psychosis. A 1H-MRS study
Gregor E Berger, Stephen J Wood, R Mark Wellard, Tina M Proffitt, Mirabel McConchie, G Paul Amminger, Graeme D Jackson, Dennis Velakoulis, Christos Pantelis, Patrick D McGorry
Ethyl-eicosapentaenoic acid (E-EPA) is an omega-3 fatty acid that has been used in a range of neuropsychiatric conditions with som..
White matter volume changes in people who develop psychosis
Mark Walterfang, Philip K McGuire, Alison R Yung, Lisa J Phillips, Dennis Velakoulis, Stephen J Wood, John Suckling, Edward T Bullmore, Warrick Brewer, Bridget Soulsby, Patricia Desmond, Patrick D McGorry, Christos Pantelis
BACKGROUND: Grey matter changes have been described in individuals who are pre- and peri-psychotic, but it is unclear if these cha..
Corpus callosum shape alterations in individuals prior to the onset of psychosis
Mark Walterfang, Alison Yung, Amanda G Wood, David C Reutens, Lisa Phillips, Stephen J Wood, Jian Chen, Dennis Velakoulis, Patrick D McGorry, Christos Pantelis
Reductions in the size of the anterior callosum have been described for both first-episode schizophrenia-spectrum psychosis and es..
Consistency and functional specialization in the default mode brain network
Ben J Harrison, Jesus Pujol, Marina Lopez-Sola, Rosa Hernandez-Ribas, Joan Deus, Hector Ortiz, Carles Soriano-Mas, Murat Yucel, Christos Pantelis, Narcis Cardoner
The notion of a "default mode of brain function" has taken on certain relevance in human neuroimaging studies and in relation to a..
Orbitofrontal, amygdala and hippocampal volumes in teenagers with first-presentation borderline personality disorder
Andrew M Chanen, Dennis Velakoulis, Kate Carison, Karen Gaunson, Stephen J Wood, Hok Pan Yuen, Murat Yucel, Henry J Jackson, Patrick D McGorry, Christos Pantelis
It is not known whether the fronto-limbic volume reductions found in adults with established borderline personality disorder (BPD)..
Toluene misuse and long-term harms: A systematic review of the neuropsychological and neuroimaging literature
Murat Yucel, Michael Takagi, Mark Walterfang, Dan I Lubman
Organic solvent abuse is associated with increased risk for serious medical, neurological, and neuropsychological impairments. Whi..
Morphology of the corpus callosum at different stages of schizophrenia: Cross-sectional study in first-episode and chronic illness
Mark Walterfang, Amanda G Wood, David C Reutens, Stephen J Wood, Jian Chen, Dennis Velakoulis, Patrick D McGorry, Christos Pantelis
<jats:sec><jats:title>Background</jats:title><jats:p>The shape of the corpus callosum may differ in schizophrenia, although no ..
Neuroanatomical correlates of temperament in early adolescents
Sarah Whittle, Murat Yucel, Alex Fornito, Anna Barrett, Stephen J Wood, Dan I Lubman, Jullan Simmons, Christos Pantelis, Nicholas B Allen
OBJECTIVE: Temperament refers to enduring behavioral characteristics that underpin individual differences in human behavior, inclu..
Regional brain abnormalities associated with long-term heavy cannabis use
Murat Yuecel, Nadia Solowij, Colleen Respondek, Sarah Whittle, Alex Fornito, Christos Pantelis, Dan I Lubman
CONTEXT: Cannabis is the most widely used illicit drug in the developed world. Despite this, there is a paucity of research examin..
Pilot Study Evaluating the Effect of Massage Therapy on Stress, Anxiety and Aggression in a Young Adult Psychiatric Inpatient Unit
Belinda Garner, Lisa J Phillips, Hans-Martin Schmidt, Connie Markulev, Jenny O'Connor, Stephen J Wood, Gregor E Berger, Peter Burnett, Patrick D McGorry
<jats:p> Objective: The aim of the present pilot study was to examine the effectiveness of a relaxation massage therapy programme ..
Abnormal white matter microstructure in schizophrenia: A voxelwise analysis of axial and radial diffusivity
Marc L Seal, Murat Yuecel, Alex Fornito, Stephen J Wood, Ben J Harrison, Mark Walterfang, Gaby S Pell, Christos Pantelis
Diffusion Tensor Imaging (DTI) investigations in schizophrenia have provided evidence of impairment in white matter as indicated b..
Olfactory identification dysfunction, aggression and impulsivity in war veterans with post-traumatic stress disorder
JF Dileo, WJ Brewer, M Hopwood, V Anderson, M Creamer
BACKGROUND: Due to neuropsychological conceptualizations of orbitoprefrontal cortex (OFC) dysfunction underpinning impulsive aggre..
Prefrontal and amygdala volumes are related to adolescents' affective behaviors during parent-adolescent interactions
Sarah Whittle, Marie BH Yap, Murat Yuecel, Alex Fornito, Julian G Simmons, Anna Barrett, Lisa Sheeber, Nicholas B Allen
Adolescence is a key period for the development of brain circuits underlying affective and behavioral regulation. It remains uncle..
Progressive changes in the development toward schizophrenia: Studies in subjects at increased symptomatic risk
Stephen J Wood, Christos Pantelis, Dennis Velakoulis, Murat Yuecel, Alex Fornito, Patrick D McGorry
Although the underlying neurobiology of emerging psychotic disorders is not well understood, there is a growing conviction that th..
Cognitive decline following psychosis onset - Data from the PACE clinic
Stephen J Wood, Warrick J Brewer, Penny Koutsouradis, Lisa J Phillips, Shona M Francey, Tina M Proffitt, Alison R Yung, Henry J Jackson, Patrick D McGorry, Christos Pantelis
BACKGROUND: The origin of cognitive impairments in psychotic disorders is still unclear. Although some deficits are apparent prior..
Fractionation of Verbal Memory Impairment in Schizophrenia and Schizophreniform Psychosis
Stephen J Wood, Aleks U Tarnawski, Tina M Proffitt, Warrick J Brewer, Greg R Savage, Vicki Anderson, Patrick D McGorry, Stephen J Wood, Aleks U Tarnawski, Tina M Proffitt, Warrick J Brewer, Greg R Savage, Vicki Anderson, Patrick D McGorry, Dennis Velakoulis, Christos Pantelis
<jats:p> Objectives: The characterization, aetiology, and course of verbal memory deficits in schizophrenia remain ill defined. Th..
Functional and biochemical alterations of the medial frontal cortex in obsessive-compulsive disorder
Murat Yucel, Ben J Harrison, Stephen J Wood, Alex Fornito, Robert M Wellard, Jesus Pujol, Kerrie Clarke, Mary L Phillips, Michael Kyrios, Dennis Velakoulis, Christos Pantelis
CONTEXT: The medial frontal cortex (MFC), including the dorsal anterior cingulate and the supplementary motor area, is critical fo..
A combined spectroscopic and functional MRI investigation of the dorsal anterior cingulate region in opiate addiction
M Yucel, DI Lubman, BJ Harrison, A Fornito, NB Allen, RM Wellard, K Roffel, K Clarke, SJ Wood, SD Forman, C Pantelis
Converging neuropsychological and functional neuroimaging evidence indicates that the dorsal anterior cingulate cortex (dACC) is d..
Anterior cingulate activation in antipsychotic-naive first-episode schizophrenia
M Yuecel, WJ Brewer, BJ Harrison, A Fornito, GJ O'Keefe, J Olver, AM Scott, GF Egan, D Velakoulis, PD McGorry, C Pantelis
UNLABELLED: Anterior cingulate (ACC) hypo-activity is commonly observed in chronically ill schizophrenia patients. However, it is ..
Increased prefrontal cerebral blood flow in first-episode schizophrenia following treatment: longitudinal positron emission tomography study
Warrick J Brewer, Murat Yucel, Ben J Harrison, Patrick D McGorry, James Olver, Gary F Egan, Dennis Velakoulis, Christos Pantelis
OBJECTIVE: Cognitive deficits, particularly those related to executive function and behavioural control, are a core feature of pat..
Dysfunction of dorsolateral prefrontal cortex in antipsychotic-naive schizophreniform psychosis
Ben J Harrison, Murat Yucel, Marnie Shaw, Warrick J Brewer, Pradeep J Nathan, Stephen C Strother, James S Olver, Gary F Egan, Dennis Velakoulis, Patrick D McGorry, Christos Pantelis
Reports of abnormal activation of the dorsolateral prefrontal cortex (dlPFC) are common in functional neuroimaging studies of schi..
The influence of sulcal variability on morphometry of the human anterior cingulate and paracingulate cortex
Alex Fornito, Sarah Whittle, Stephen J Wood, Dennis Velakoulis, Christos Pantelis, Murat Yucel
Human anterior cingulate (ACC) and paracingulate (PaC) cortices play an important role in cognitive and affective regulation and h..