Migration and differentiation of enteric neuron precursors
Grant number: 145628
There are many millions of nerve cells within the wall of the intestine, and they control many intestinal functions, including motility. During development, these nerve cells arise from cells which migrate away from the developing brain and first enter the stomach. The migratory cells are called neural crest cells. After entering the stomach, neural crest cells migrate within the wall of the gastrointestinal tract, until they reach the far (anal) end. In embryonic mice, this colonisation of the entire small and large intestines by neural crest cells takes over 4 days, and in humans the process probably takes at least one week. It is essential that the neural crest cells colonise the entire g..View full description
Related publications (5)
Effects of pharmacological inhibition of small GTPases on axon extension and migration of enteric neural crest-derived cells
Ashley L Stewart, Heather M Young, Michel Popoff, Richard B Anderson
In the developing enteric nervous system, there is a close association between migrating neural crest-derived cells and the axons ..
Dynamics of neural crest-derived cell migration in the embryonic mouse gut
HM Young, AJ Bergner, RB Anderson, H Enomoto, J Milbrandt, DF Newgreen, PM Whitington
Neural crest-derived cells that form the enteric nervous system undergo an extensive migration from the caudal hindbrain to coloni..