NEURODEGENERATIVE DISEASES OF THE AGING BRAIN: DIAGNOSIS & THERAPY BASED ON THE STUDY OF AGGREAGATED PROTEIN DEPOSITIONS

A Serial Analysis of Gene Expression Profile of the Alzheimer's Disease Tg2576 Mouse Model

Amee J George, Lavinia Gordon, Tim Beissbarth, Irene Koukoulas, RM Damian Holsinger, Victoria Perreau, Roberto Cappai, Seong-Seng Tan, Colin L Masters, Hamish S Scott, Qiao-Xin Li

2010-05-01

Serial analysis of gene expression (SAGE), a technique that allows for the simultaneous detection of expression levels of the enti..

SAGE Analysis of Genes Differentially Expressed in Presymptomatic TgSOD1(G93A) Transgenic Mice Identified Cellular Processes Involved in Early Stage of ALS Pathology

Michel Guipponi, Qiao-Xin Li, Lavinia Hyde, Tim Beissbarth, Gordon K Smyth, Colin L Masters, Hamish S Scott

2010-05-01

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition in which motor neurons of the spinal cord and motor cor..

Analysis of endogenous PrPC processing in neuronal and non-neuronal cell lines.

Victoria Lewis, Steven J Collins

2008-01-01

Numerous transmembrane and glycosylphosphatidylinositol (GPI)-anchored proteins, covering a vast range of structural and functiona..

Chronic exposure to U18666A is associated with oxidative stress in cultured murine cortical neurons

Chor Hui Vivien Koh, Matthew Whiteman, Qiao-Xin Li, Barry Halliwell, Andrew M Jenner, Boon Seng Wong, Katrina M Laughton, Markus Wenk, Colin L Masters, Philip M Beart, Ora Bernard, Nam Sang Cheung

2006-08-01

Findings that antioxidant treatment may be beneficial in Alzheimer's disease indicate that oxidative stress is an important factor..

Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: Implications for Alzheimer beta-amyloid pathology

Christa J Maynard, Roberto Cappai, Irene Volitakis, Robert A Cherny, Colin L Masters, Qiao-Xin Li, Ashley I Bush

2006-05-01

The incidence of Alzheimer's disease (AD) is greater in women than men at any age, as is the development of amyloid pathology in s..

Overexpression of A beta is associated with acceleration of onset of motor impairment and superoxide dismutase 1 aggregation in an amyotrophic lateral sclerosis mouse model

QX Li, S San Mok, KM Laughton, CA McLean, I Volitakis, RA Cherny, NS Cheung, AR White, CL Masters

2006-04-01

Transgenic mice carrying mutant Cu/Zn superoxide dismutase (SOD1) recapitulate the motor impairment of human amyotrophic lateral s..

Correlative studies support lipid peroxidation is linked to PrPres propagation as art early primary pathogenic event in prion disease

MW Brazier, V Lewis, GD Ciccotosto, GM Klub, VA Lawson, R Cappai, JW Ironside, CL Masters, AF Hill, AR White, S Collins

2006-01-30

To assess whether heightened oxidative stress plays an early and primary pathogenic role in transmissible spongiform encephalopath..

Extended period of asymptomatic prion disease after low dose inoculation: Assessment of detection methods and implications for infection control

SJ Collins, V Lewis, MW Brazier, AF Hill, VA Lawson, GM Klug, CL Masters

2005-11-01

We used quantal dose-titration of a mouse-adapted human transmissible spongiform encephalopathy strain (M470) to compare different..

In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc

DE Hoke, JL Tan, NT Ilaya, JG Culvenor, SJ Smith, AR White, CL Masters, GM Evin

2005-11-01

The gamma-secretase complex mediates the final proteolytic event in Alzheimer's disease amyloid-beta biogenesis. This membrane com..

Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations

JG Culvenor, NT Ilaya, MT Ryan, L Canterford, DE Hoke, NA Williamson, CA McLean, CL Masters, G Evin

2004-01-01

The presenilin proteins are required for intramembrane cleavage of a subset of type 1 membrane proteins including the Alzheimer's ..

Quinacrine does not prolong survival in a murine Creutzfeldt-Jakob disease model

SJ Collins, V Lewis, M Brazier, AF Hill, A Fletcher, CL Masters

2002-10-01

Paramount among issues relating to the transmissible spongiform encephalopathies (also known as prion diseases) is the absence of ..