NEURODEGENERATIVE DISEASES OF THE AGING BRAIN: DIAGNOSIS & THERAPY BASED ON THE STUDY OF AGGREAGATED PROTEIN DEPOSITIONS
Grant number: 208978
Related publications (11)
A Serial Analysis of Gene Expression Profile of the Alzheimer's Disease Tg2576 Mouse Model
Amee J George, Lavinia Gordon, Tim Beissbarth, Irene Koukoulas, RM Damian Holsinger, Victoria Perreau, Roberto Cappai, Seong-Seng Tan, Colin L Masters, Hamish S Scott, Qiao-Xin Li
Serial analysis of gene expression (SAGE), a technique that allows for the simultaneous detection of expression levels of the enti..
SAGE Analysis of Genes Differentially Expressed in Presymptomatic TgSOD1(G93A) Transgenic Mice Identified Cellular Processes Involved in Early Stage of ALS Pathology
Michel Guipponi, Qiao-Xin Li, Lavinia Hyde, Tim Beissbarth, Gordon K Smyth, Colin L Masters, Hamish S Scott
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition in which motor neurons of the spinal cord and motor cor..
Chronic exposure to U18666A is associated with oxidative stress in cultured murine cortical neurons
Chor Hui Vivien Koh, Matthew Whiteman, Qiao-Xin Li, Barry Halliwell, Andrew M Jenner, Boon Seng Wong, Katrina M Laughton, Markus Wenk, Colin L Masters, Philip M Beart, Ora Bernard, Nam Sang Cheung
Findings that antioxidant treatment may be beneficial in Alzheimer's disease indicate that oxidative stress is an important factor..
Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: Implications for Alzheimer beta-amyloid pathology
Christa J Maynard, Roberto Cappai, Irene Volitakis, Robert A Cherny, Colin L Masters, Qiao-Xin Li, Ashley I Bush
The incidence of Alzheimer's disease (AD) is greater in women than men at any age, as is the development of amyloid pathology in s..
Overexpression of A beta is associated with acceleration of onset of motor impairment and superoxide dismutase 1 aggregation in an amyotrophic lateral sclerosis mouse model
QX Li, S San Mok, KM Laughton, CA McLean, I Volitakis, RA Cherny, NS Cheung, AR White, CL Masters
Transgenic mice carrying mutant Cu/Zn superoxide dismutase (SOD1) recapitulate the motor impairment of human amyotrophic lateral s..
Correlative studies support lipid peroxidation is linked to PrPres propagation as art early primary pathogenic event in prion disease
MW Brazier, V Lewis, GD Ciccotosto, GM Klub, VA Lawson, R Cappai, JW Ironside, CL Masters, AF Hill, AR White, S Collins
To assess whether heightened oxidative stress plays an early and primary pathogenic role in transmissible spongiform encephalopath..
Extended period of asymptomatic prion disease after low dose inoculation: Assessment of detection methods and implications for infection control
SJ Collins, V Lewis, MW Brazier, AF Hill, VA Lawson, GM Klug, CL Masters
We used quantal dose-titration of a mouse-adapted human transmissible spongiform encephalopathy strain (M470) to compare different..
In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc
DE Hoke, JL Tan, NT Ilaya, JG Culvenor, SJ Smith, AR White, CL Masters, GM Evin
The gamma-secretase complex mediates the final proteolytic event in Alzheimer's disease amyloid-beta biogenesis. This membrane com..
Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations
JG Culvenor, NT Ilaya, MT Ryan, L Canterford, DE Hoke, NA Williamson, CA McLean, CL Masters, G Evin
The presenilin proteins are required for intramembrane cleavage of a subset of type 1 membrane proteins including the Alzheimer's ..