Redefining the Immune Landscape of the Human Ocular Surface

Altered Corneal T-Cell Motility and Sensory Nerve Features in Older Adults With Human Immunodeficiency Virus Infection

S Karunaratne, M Wu, X Yu, SJ Kent, J Silvers, P Bedggood, A Metha, SN Mueller, KJ Selva, AW Chung, HR Chinnery, BN Nguyen, LE Downie

2025-09-10

PURPOSE. To characterize corneal immune cell morphodynamics and nerve features, and define the in vivo immune landscape in older a..

Redefining our vision: an updated guide to the ocular immune system

M Wu, EL Fletcher, HR Chinnery, LE Downie, SN Mueller

2024-12-01

Balanced immune responses in the eyes are crucial to preserve vision. The ocular immune system has long been considered distinct, ..

Improved tracking of corneal immune cell dynamics using in vivo confocal microscopy

P Bedggood, M Wu, X Zhang, R Rajan, CYI Wu, S Karunaratne, AB Metha, SN Mueller, HR Chinnery, LE Downie

2024-11-01

In vivo confocal microscopy (IVCM) is a widely used technique for imaging the cornea of the eye with a confocal scanning light oph..

Intravital Imaging of the Human Cornea Reveals the Differential Effects of Season on Innate and Adaptive Immune Cell Morphodynamics

M Wu, X Zhang, S Karunaratne, JH Lee, ER Lampugnani, KJ Selva, AW Chung, SN Mueller, HR Chinnery, LE Downie

2024-10-01

Purpose: Defining how the in vivo immune status of peripheral tissues is shaped by the external environment has remained a technic..