Longitudinal brain changes in first-episode psychosis: A 10 year follow-up MRI study

Abstract

It is now widely accepted that schizophrenia is associated with changes in the structure of the brain. Until recently these structural changes were considered to predate the onset of illness and to remain static. However, our own work has suggested an alternative model, which relates schizophrenia to brain changes at specific life stages. In order to demonstrate this, we intend to acquire repeat brain images on 100 patients who were initially scanned 10 years ago at the start of their psychotic illness. This would be the largest follow-up study of first episode psychosis in the world, with the longest interval between the first and second brain scan. Further, for a proportion of patients we ..

Related publications (1)

Progressive changes in the development toward schizophrenia: Studies in subjects at increased symptomatic risk

Stephen J Wood, Christos Pantelis, Dennis Velakoulis, Murat Yuecel, Alex Fornito, Patrick D McGorry

2008-03-01

Although the underlying neurobiology of emerging psychotic disorders is not well understood, there is a growing conviction that th..