In vivo tissue engineering of adipose tissue for reconstructive surgery
Grant number: 299872
We are able to grow vascularised tissue in implanted plastic chambers to a predetermined size and shape in the rat and mouse (NHMRC Project Grant 01-03; #145782; CIA Morrison). The basis of this growth is blood vessel sprouting from the surface of the vessel bundle or loop, followed by synthesis of structural molecules and the migration of surrounding cells into the vascularised network to form a stable tissue. Unlike other in vivo models of tissue engineering, the tissue grows spontaneously and is densely vascularised, enabling continuous growth and surgically transfer to another part of the body, or to another animal. In this renewal application of the above NHMRC grant, we propose to dire..View full description
Related publications (3)
Adipose differentiation of bone marrow-derived mesenchymal stem cells using Pluronic F-127 hydrogel in vitro
Aditya V Vashi, Efthimia Keramidaris, Keren M Abberton, Wayne A Morrison, Jeremy L Wilson, Andrea J O'Connor, Justin J Cooper-White, Erik W Thompson
Due to increasing clinical demand for adipose tissue, a suitable scaffold for engineering adipose tissue constructs is needed. In ..
Monocyte chemoattractant protein-1 and nitric oxide promote adipogenesis in a model that mimics obesity
Karsten Hemmrich, Gregory PL Thomas, Keren M Abberton, Erik W Thompson, John A Rophael, Anthony J Penington, Wayne A Morrison
OBJECTIVE: An increasing body of evidence is emerging linking adipogenesis and inflammation. Obesity, alone or as a part of the me..