Retinal microvascular signs and CVD in older persons
Grant number: 1 R21 HL077166-01
Related publications (30)
Retinal Microvascular Signs and Risk of Stroke The Multi-Ethnic Study of Atherosclerosis (MESA)
Ryo Kawasaki, Jing Xie, Ning Cheung, Ecosse Lamoureux, Ronald Klein, Barbara EK Klein, Mary Frances, A Richey Sharrett, Steven Shea, Tien Y Wong
BACKGROUND AND PURPOSE: Small-vessel disease contributes to the pathophysiology of stroke, and retinal microvascular signs have be..
Ten-Year Longitudinal Changes in Retinal Microvascular Lesions The Atherosclerosis Risk in Communities Study
Gerald Liew, Stephen Campbell, Ronald Klein, Barbara EK Klein, A Richey Sharrett, Mary Frances Cotch, Jie Jin Wang, Tien Y Wong
OBJECTIVE: There are limited data on the natural history and longitudinal changes of retinal microvascular lesions. We examined 10..
Is Diabetic Retinopathy Related to Subclinical Cardiovascular Disease?
Ryo Kawasaki, Ning Cheung, FM Amirul Islam, Ronald Klein, Barbara EK Klein, Mary Frances Cotch, A Richey Sharrett, Daniel O'Leary, Tien Y Wong
OBJECTIVE: Persons with diabetic retinopathy (DR) have an increased risk of clinical cardiovascular events. This study aimed to de..
Association between Physical Activity and Retinal Microvascular Signs: The Atherosclerosis Risk in Communities (ARIC) Study
Gabriella Tikellis, Satyamurthy Anuradha, Ronald Klein, Tien Y Wong
OBJECTIVE: To examine the association between physical activity measured during leisure, sport, and work and retinal microvascular..
Retinal microvascular abnormalities and cognitive decline The ARIC 14-year follow-up study
SR Lesage, TH Mosley, TY Wong, M Szklo, D Knopman, DJ Catellier, SR Cole, R Klein, J Coresh, LH Coker, AR Sharrett
BACKGROUND: Because retinal and cerebral arterioles share similar pathologic processes, retinal microvascular changes are expected..
Hypertension genes and retinal vascular calibre: the Cardiovascular Health Study
C Sun, JJ Wang, FM Islam, SR Heckbert, R Klein, DS Siscovick, BEK Klein, TY Wong
We examined the associations of single nucleotide polymorphisms (SNPs) in three candidate hypertension genes, alpha-adducin (ADD1/..
Early Age-Related Macular Degeneration, Cognitive Function, and Dementia The Cardiovascular Health Study
Michelle L Baker, Jie Jin Wang, Sophie Rogers, Ronald Klein, Lewis H Kuller, Emily K Larsen, Tien Yin Wong
OBJECTIVE: To describe the association of cognitive function and dementia with early age-related macular degeneration (AMD) in old..
Vital Exhaustion and Retinal Microvascular Changes in Cardiovascular Disease: Atherosclerosis Risk in Communities Study
Ning Cheung, Sophie Rogers, Thomas H Mosley, Ronald Klein, David Couper, Tien Y Wong
OBJECTIVE: To determine if vital exhaustion, a measure of negative emotion, is associated with microvascular changes in the retina..
Risk prediction of coronary heart disease based on retinal vascular caliber (from the Atherosclerosis Risk In Communities [ARIC] study)
Kevin McGeechan, Gerald Liew, Petra Macaskill, Les Irwig, Ronald Klein, A Richey Sharrett, Barbara EK Klein, Jie J Wang, Lloyd E Charabless, Tien Y Wong
Recent studies showed that such retinal vascular signs as quantitative retinal vascular caliber were associated with increased ris..
Low birthweight is associated with narrower arterioles in adults
Gerald Liew, Jie Jin Wang, Bruce B Duncan, Ronald Klein, A Richey Sharrett, Frederick Brancati, Hsin-Chieh Yeh, Paul Mitchell, Tien Y Wong
Low birthweight is associated with increased risk of hypertension, but underlying mechanisms are obscure. We hypothesized structur..
Birth weight is not related to risk of diabetic retinopathy in type 2 diabetes: The atherosclerosis risk in communities study
G Liew, JJ Wang, R Klein, BB Duncan, HC Yeh, FL Brancati, P Mitchell, TY Wong
PURPOSE: Low birth weight has been suggested as a risk factor for diabetes. Whether it is related to diabetic retinopathy is uncle..
The relationship between birthweight and early age-related maculopathy: The atherosclerosis risk in communities study
Gerald Liew, Jie Jin Wang, Ronald Klein, Bruce B Duncan, Frederick Brancati, Hsin-Chieh Yeh, Tien Y Wong
PURPOSE: Birthweight is a marker of fetal growth, and has been linked to future risk of chronic diseases in adults. We examined th..
Apolipoprotein E gene and retinal microvascular signs in older people: the Cardiovascular Health Study
Cong Sun, Gabriella Tikellis, Gerald Liew, Ronald Klein, Emily K Marino Larsen, Tien Y Wong
PURPOSE: To examine the association between apolipoprotein E (APOE) gene polymorphism and retinal microvascular signs in an older ..
Retinal microvascular signs, cognitive function, and dementia in older persons - The cardiovascular health study
Michelle L Baker, Emily K Marino Larsen, Lewis H Kuller, Ronald Klein, Barbara EK Klein, David S Siscovick, Charles Bernick, Teri A Manolio, Tien Yin Wong
BACKGROUND AND PURPOSE: Cerebral microvascular disease may be a risk factor for the development of dementia in elderly persons. We..
Are microvascular abnormalities in the retina associated with depression symptoms? The Cardiovascular Health Study
Cong Sun, Gabriella Tikellis, Ronald Klein, David C Steffens, Emily K Marino Larsen, David S Siscovick, Barbara EK Klein, Tien Y Wong
OBJECTIVE: Depression has been linked with vascular risk factors and stroke. The authors examined the relationship between retinal..
Age-related macular degeneration and risk of coronary heart disease - The atherosclerosis risk in communities study
Tien Yin Wong, Gabriella Tikellis, Cong Sun, Ronald Klein, David J Couper, A Richey Sharrett
OBJECTIVE: To examine the association of age-related macular degeneration (AMD) with incident coronary heart disease (CHD) and all..
Apolipoprotein E gene and age-related maculopathy in older individuals - The Cardiovascular Health Study
Gabriella Tikellis, Cong Sun, Michael B Gorin, Ronald Klein, Barbara EK Klein, Emily K Marino Larsen, David S Siscovick, Larry D Hubbard, Tien Y Wong
OBJECTIVE: To examine the association between the apolipoprotein E (APOE) gene and age-related maculopathy (ARM) in an older popul..
Quantitative retinal venular caliber and risk of cardiovascular disease in older persons - The Cardiovascular Health Study
Tien Yin Wong, Aruna Kamineni, Ronald Klein, A Richey Sharrett, Barbara E Klein, David S Siscovick, Mary Cushman, Bruce B Duncan
BACKGROUND: Small vessel disease may contribute to the risk of cardiovascular disease in older persons. We describe the relation o..
Age-related macular degeneration and risk for stroke
Tien Yin Wong, Ronald Klein, Sun Cong, Paul Mitchell, David J Couper, Lai Hong, Larry D Hubbard, A Richey Sharrett
BACKGROUND: Age-related macular degeneration (AMD) affects 7 million persons 40 years of age and older in the United States. Risk ..
Retinal microvascular abnormalities and MRI-defined subclinical cerebral infarction - The atherosclerosis risk in communities study
LS Cooper, TY Wong, R Klein, AR Sharrett, RN Bryan, LD Hubbard, DJ Couper, G Heiss, PD Sorlie
BACKGROUND AND PURPOSE: Retinal microvascular abnormalities reflect cumulative small vessel damage from elevated blood pressure an..
Cardiovascular risk factors for retinal vein occlusion and arteriolar emboli - The Atherosclerosis Risk in Communities & Cardiovascular Health Studies
TY Wong, EKM Larsen, R Klein, P Mitchell, DJ Couper, BEK Klein, LD Hubbard, DS Siscovick, AR Sharrett
OBJECTIVE: To examine the associations of retinal vein occlusion and arteriolar emboli with cardiovascular disease. DESIGN: Popula..