Bone size and bone turnover: relationship to fracture risk over ten years
Grant number: 251638
The occurrence of fracture in the ageing population is a major public health problem because these fractures are responsible for considerable morbidity and mortality. Of women reaching 90 years of age, one third will fracture their hip and overall, one in every six women will sustain an osteoporotic fracture in her lifetime. The direct cost to the community is unknown but estimated, conservatively, at 175 million dollars annually. Most of this is likely to be the result of hip fractures which occupy an estimated 400,000 bed-days annually. This bed occupancy is fourth next to mental illness, cardiac disease and cancer. The Geelong Osteoporosis Study is a large population-based epidemiological..View full description
Related publications (53)
Mood disorder and cancer onset: evidence from a population-based sample of Australian women
Stephanie P Cowdery, Amanda L Stuart, Julie A Pasco, Michael Berk, David Campbell, Ottar Bjerkeset, Lana J Williams
OBJECTIVE: The role of mood disorders in cancer onset is unclear. The aim of this study was to investigate the association between..
Dynapenia and Low Cognition: A Cross-Sectional Association in Postmenopausal Women
Julie A Pasco, Amanda L Stuart, Sophia X Sui, Kara L Holloway-Kew, Natalie K Hyde, Monica C Tembo, Pamela Rufus-Membere, Mark A Kotowicz, Lana J Williams
Dynapenia is a key contributor to physical frailty. Cognitive impairment and dementia accompany frailty, yet links between skeleta..
Prevalence of Sarcopenia Employing Population-Specific Cut-Points: Cross-Sectional Data from the Geelong Osteoporosis Study, Australia
Sophia X Sui, Kara L Holloway-Kew, Natalie K Hyde, Lana J Williams, Monica C Tembo, Sarah Leach, Julie A Pasco
BACKGROUND: Prevalence estimates for sarcopenia vary depending on the ascertainment criteria and thresholds applied. We aimed to e..
Physical and lifestyle factors associated with trabecular bone score values
Kara B Anderson, Kara L Holloway-Kew, Didier Hans, Mark A Kotowicz, Natalie K Hyde, Julie A Pasco
TBS is associated with age, weight, childhood physical activity, and BMD in men and age, height, BMD, and mobility in women. INTRO..
Validity of self-reported cancer: Comparison between self-report versus cancer registry records in the Geelong Osteoporosis Study
Stephanie P Cowdery, Amanda L Stuart, Julie A Pasco, Michael Berk, David Campbell, Lana J Williams
BACKGROUND: Determining the validity of self-reported data is important. The aim of this study was to assess the validity of self-..
Skeletal Muscle Density and Cognitive Function: A Cross-Sectional Study in Men
Sophia X Sui, Lana J Williams, Kara L Holloway-Kew, Natalie K Hyde, Kara B Anderson, Monica C Tembo, Alex B Addinsall, Sarah Leach, Julie A Pasco
We aimed to investigate cross-sectional associations between skeletal muscle density, a proxy measure for fatty infiltration into ..
Total Antioxidant Capacity and Frailty in Older Men
Monica C Tembo, Kara L Holloway-Kew, Chiara C Bortolasci, Sophia X Sui, Sharon L Brennan-Olsen, Lana J Williams, Mark A Kotowicz, Julie A Pasco
Frailty, a clinical syndrome characterized by multisystem dysregulation, has been associated with high levels of oxidative stress...
Prevalence of Frailty in Older Men and Women: Cross-Sectional Data from the Geelong Osteoporosis Study
Monica C Tembo, Kara L Holloway-Kew, Sophia X Sui, Trisha Dunning, Adrian CH Low, Shi-Jynn Yong, Boon L Ng, Sharon L Brennan-Olsen, Lana J Williams, Mark A Kotowicz, Julie A Pasco
Few studies have investigated the prevalence of frailty in the Australian general population. This study determined the prevalence..
Muscle strength and gait speed rather than lean mass are better indicators for poor cognitive function in older men
Sophia X Sui, Kara L Holloway-Kew, Natalie K Hyde, Lana J Williams, Sarah Leach, Julie A Pasco
We aimed to examine muscle strength, function and mass in relation to cognition in older men. This cross-sectional data-set includ..
The association between a fracture risk tool and frailty: Geelong Osteoporosis Study
Monica C Tembo, Kara L Holloway-Kew, Mohammadreza Mohebbi, Sophia X Sui, Sarah M Hosking, Sharon L Brennan-Olsen, Lana J Williams, Mark A Kotowicz, Julie A Pasco
BACKGROUND: Frailty is characterised by age-related declines in physical, psychological and social functioning. Features of frailt..
Repurposing a fracture risk calculator (FRAX) as a screening tool for women at risk for sarcopenia
JA Pasco, M Mohebbi, MC Tembo, KL Holloway-Kew, NK Hyde, LJ Williams, MA Kotowicz
Osteoporosis and sarcopenia share risk profiles, so we tested a fracture risk assessment tool (FRAX) as a screening tool for sarco..
Handgrip strength and muscle quality in Australian women: cross-sectional data from the Geelong Osteoporosis Study
Sophia X Sui, Kara L Holloway-Kew, Natalie K Hyde, Lana J Williams, Monica C Tembo, Mohammadreza Mohebbi, Marlene Gojanovic, Sarah Leach, Julie A Pasco
BACKGROUND: Low handgrip strength (HGS) is a measure of poor skeletal muscle performance and a marker of ill health and frailty. M..
Lower-limb muscle strength: normative data from an observational population-based study
Julie A Pasco, Amanda L Stuart, Kara L Holloway-Kew, Monica C Tembo, Sophia X Sui, Kara B Anderson, Natalie K Hyde, Lana J Williams, Mark A Kotowicz
BACKGROUND: The extent of muscle deterioration associated with ageing or disease can be quantified by comparison with appropriate ..
FRAX (Australia) scores in women with impaired fasting glucose and diabetes
Lelia LF de Abreu, Kara L Holloway-Kew, Muhammad A Sajjad, Mark A Kotowicz, Julie A Pasco
Background: Diabetes is associated with higher fracture risk despite higher bone mineral density (BMD), with FRAX® underestimating..
Association between dairy intake and fracture in an Australian-based cohort of women: a prospective study
Hajara Aslam, Kara L Holloway-Kew, Mohammadreza Mohebbi, Felice N Jacka, Julie A Pasco
OBJECTIVE: Given the inconsistent evidence on dairy consumption and risk of fracture, we assessed the association between milk/tot..
How well do the FRAX (Australia) and Garvan calculators predict incident fractures? Data from the Geelong Osteoporosis Study
KL Holloway-Kew, Y Zhang, AG Betson, KB Anderson, D Hans, K Hyde, GC Nicholson, NA Pocock, MA Kotowicz, JA Pasco
This study reports that both FRAX and Garvan calculators underestimated fractures in Australian men and women, particularly in tho..
Bone Turnover Markers in Men and Women with Impaired Fasting Glucose and Diabetes
Kara L Holloway-Kew, Lelia LF De Abreu, Mark A Kotowicz, Muhammad A Sajjad, Julie A Pasco
Bone turnover markers (BTMs) are reduced in diabetes, but whether BTM changes occur in impaired fasting glucose (IFG) is unknown. ..
Reference Ranges for Trabecular Bone Score in Australian Men and Women: A Cross-Sectional Study.
Kara B Anderson, Kara L Holloway-Kew, Didier Hans, Mark A Kotowicz, Natalie K Hyde, Julie A Pasco
Trabecular bone score (TBS) is a novel method for indirectly assessing trabecular microarchitecture at the lumbar spine, providing..
Normative Data for Lean Mass Using FNIH Criteria in an Australian Setting
Julie A Pasco, Kara L Holloway-Kew, Monica C Tembo, Sophia X Sui, Kara B Anderson, Pamela Rufus-Membere, Natalie K Hyde, Lana J Williams, Mark A Kotowicz
Recommendations from the FNIH Sarcopenia Project are that appendicular lean mass (ALM, kg) adjusted for body mass index (BMI, kg/m..
Fracture Risk in Women with Dysglycaemia: Assessing Effects of Baseline and Time-Varying Risk Factors
Lelia LF de Abreu, Kara L Holloway-Kew, Mohammadreza Mohebbi, Muhammad A Sajjad, Mark A Kotowicz, Julie A Pasco
Although individuals with diabetes appear to have a higher fracture risk compared to those without diabetes, fracture risk in impa..
Prediction of major osteoporotic and hip fractures in Australian men using FRAX scores adjusted with trabecular bone score
KL Holloway, M Mohebbi, AG Betson, D Hans, NK Hyde, SL Brennan-Olsen, MA Kotowicz, JA Pasco
There was no significant difference between the areas under receiver operating characteristics (AUROCs) and diagnostic indexes (se..
Trabecular Bone Score in Men and Women with Impaired Fasting Glucose and Diabetes
Kara L Holloway, Lelia LF De Abreu, Didier Hans, Mark A Kotowicz, Muhammad A Sajjad, Natalie K Hyde, Julie A Pasco
Diabetes is associated with increased skeletal fragility, despite higher bone mineral density (BMD). Alternative measures are nece..
Personality disorder is an excess risk factor for physical multimorbidity among women with mental state disorders
Shae E Quirk, Amanda L Stuart, Michael Berk, Julie A Pasco, Sharon L Brennan Olsen, Heli Koivumaa-Honkanen, Risto Honkanen, Pyry S Lukkala, Andrew M Chanen, Mark Kotowicz, Lana J Williams
We examined whether mental state disorders (lifetime mood, anxiety, eating, substance misuse) with comorbid personality disorder a..
Lower limb fracture presentations at a regional hospital
KL Holloway, D Yousif, G Bucki-Smith, S Hosking, AG Betson, LJ Williams, SL Brennan-Olsen, MA Kotowicz, A Sepetavc, JA Pasco
We found that lower limb fractures, which were largely the result of minimal trauma, had high levels of hospitalisation, length of..
Musculoskeletal decline and mortality: prospective data from the Geelong Osteoporosis Study
Julie A Pasco, Mohammadreza Mohebbi, Kara L Holloway, Sharon L Brennan-Olsen, Natalie K Hyde, Mark A Kotowicz
BACKGROUND: We aimed to examine the relationship between musculoskeletal deterioration and all-cause mortality in a cohort of wome..
All-Cause Mortality Risk in Australian Women with Impaired Fasting Glucose and Diabetes
Lelia LF de Abreu, Kara L Holloway, Mohammadreza Mohebbi, Muhammad A Sajjad, Mark A Kotowicz, Julie A Pasco
AIMS: Impaired fasting glucose (IFG) and diabetes are increasing in prevalence worldwide and lead to serious health problems. The ..
A conduit between epidemiological research and regional health policy
Julie A Pasco, Chad Foulkes, Brianna Doolan, Kirsty Brown, Kara L Holloway, Sharon L Brennan-Olsen
OBJECTIVE: To transform data from a research setting into a format that could be used to support strategies encouraging healthy li..
The addition of depression to the Framingham Risk Equation model for predicting coronary heart disease risk in women
Adrienne O'Neil, Aaron J Fisher, Katherine J Kibbey, Felice N Jacka, Mark A Kotowicz, Lana J Williams, Amanda L Stuart, Michael Berk, Paul A Lewandowski, John J Atherton, Craig B Taylor, Julie A Pasco
BACKGROUND: Depression is widely considered to be an independent and robust predictor of Coronary Heart Disease (CHD), however is ..
Humeral Fractures in South-Eastern Australia: Epidemiology and Risk Factors
Kara L Holloway, Gosia Bucki-Smith, Amelia G Morse, Sharon L Brennan-Olsen, Mark A Kotowicz, David J Moloney, Kerrie M Sanders, Sam Korn, Elizabeth N Timney, Amelia G Dobbins, Julie A Pasco
In this study, we report the epidemiology and risk factors for humeral fractures (proximal humerus and shaft) among men and women ..
Excessive daytime sleepiness and falls among older men and women: cross-sectional examination of a population-based sample
Amie C Hayley, Lana J Williams, Gerard A Kennedy, Kara L Holloway, Michael Berk, Sharon L Brennan-Olsen, Julie A Pasco
BACKGROUND: Excessive daytime sleepiness (EDS) has been associated with an increased risk for falls among clinical samples of olde..
Muscle strength and areal bone mineral density at the hip in women: a cross-sectional study
Julie A Pasco, Kara L Holloway, Sharon L Brennan-Olsen, David J Moloney, Mark A Kotowicz
BACKGROUND: Muscle strengthening exercises are promoted for building and maintaining a healthy skeleton. We aimed to investigate t..
Psychiatric disorders, psychotropic medication use and falls among women: an observational study
Lana J Williams, Julie A Pasco, Amanda L Stuart, Felice N Jacka, Sharon L Brennan, Amelia G Dobbins, Risto Honkanen, Heli Koivumaa-Honkanen, Paivi H Rauma, Michael Berk
BACKGROUND: Psychotropic agents known to cause sedation are associated with an increased risk of falls, but the role of psychiatri..
Age- and Sex-Related Patterns of First Fracture and Fracture Prevalence
Kara L Holloway, Sharon L Brennan, Mark A Kotowicz, Gosia Bucki-Smith, Amelia G Dobbins, Elizabeth N Timney, Lana J Williams, Julie A Pasco
There are few data documenting the pattern of prevalent fracture across the entire adult age range, so we aimed to address this ga..
Dysglycaemia and Other Predictors for Progression or Regression from Impaired Fasting Glucose to Diabetes or Normoglycaemia
L de Abreu, Kara L Holloway, Mark A Kotowicz, Julie A Pasco
AIMS: Diabetes mellitus is a growing health problem worldwide. This study aimed to describe dysglycaemia and determine the impact ..
Small area-level socioeconomic status and all-cause mortality within 10 years in a population-based cohort of women: Data from the Geelong Osteoporosis Study.
Sharon L Brennan-Olsen, Lana J Williams, Kara L Holloway, Sarah M Hosking, Amanda L Stuart, Amelia G Dobbins, Julie A Pasco
BACKGROUND: The social gradient of health and mortality is well-documented. However, data are scarce regarding whether differences..
Total and Appendicular Lean Mass Reference Ranges for Australian Men and Women: The Geelong Osteoporosis Study
Haslinda Gould, Sharon L Brennan, Mark A Kotowicz, Geoffrey C Nicholson, Julie A Pasco
The aim of this study was to develop reference ranges for total and appendicular lean mass measured using dual-energy X-ray absorp..
Fracture risk among older men: osteopenia and osteoporosis defined using cut-points derived from female versus male reference data
JA Pasco, SE Lane, SL Brennan, EN Timney, G Bucki-Smith, AG Dobbins, GC Nicholson, MA Kotowicz
SUMMARY: We explored the effect of using male and female reference data in a male sample to categorise areal bone mineral density ..
Associations between measures of adiposity over 10 years and patella cartilage in population-based asymptomatic women
AJ Gunardi, SL Brennan, Y Wang, Flavia M Cicuttini, JA Pasco, MA Kotowicz, GC Nicholson, Anita Wluka
OBJECTIVE: Osteoarthritis (OA) most commonly affects the patellofemoral compartment of the knee, and is a major cause of pain and ..
Endogenous parathyroid hormone is associated with reduced cartilage volume in vivo in a population-based sample of adult women
Sharon Lee Brennan, Flavia M Cicuttini, Geoff C Nicholson, Julie A Pasco, Mark A Kotowicz, Anita Wluka
OBJECTIVES: Animal and in vitro studies suggest that parathyroid hormone (PTH) may affect articular cartilage. However, little is ..
Bipolar disorder and adiposity: a study using whole body dual energy X-ray absorptiometry scans
Lana J Williams, Julie A Pasco, Felice N Jacka, Margaret J Henry, Seetal Dodd, Geoffrey C Nicholson, Mark A Kotowicz, Michael Berk
Objective: Previous research has demonstrated a relationship between adiposity and bipolar disorder, although data are derived pre..
Bone mineral density is cross sectionally associated with cartilage volume in healthy, asymptomatic adult females: Geelong Osteoporosis Study
SL Brennan, JA Pasco, Flavia M Cicuttini, MJ Henry, MA Kotowicz, GC Nicholson, Anita Wluka
INTRODUCTION: The association between osteoporosis and osteoarthritis (OA) is controversial. Although previous studies have shown ..
Changes in Hip Fracture Rates in Southeastern Australia Spanning the Period 1994-2007
Julie A Pasco, Sharon L Brennan, Margaret J Henry, Geoffrey C Nicholson, Kerrie M Sanders, Yu Zhang, Mark A Kotowicz
Hip fracture incidence rates appear to be declining in Western populations. Utilizing comprehensive incident hip fracture data fro..
Paracetamol (acetaminophen) use, fracture and bone mineral density
Lana J Williams, Julie A Pasco, Margaret J Henry, Kerrie M Sanders, Geoffrey C Nicholson, Mark A Kotowicz, Michael Berk
Paracetamol is the most widely prescribed simple analgesic and antipyretic. It exerts its effects via cyclooxygenase and endocanna..
Prevalence of mood and anxiety disorder in self reported irritable bowel syndrome (IBS). An epidemiological population based study of women
Arnstein Mykletun, Felice Jacka, Lana Williams, Julie Pasco, Margaret Henry, Geoffrey C Nicholson, Mark A Kotowicz, Michael Berk
BACKGROUND: Irritable bowel syndrome (IBS) is commonly regarded as a functional disorder, and is hypothesized to be associated wit..
The prevalence of mood and anxiety disorders in Australian women
Lana Williams, Felice Jacka, Julie Pasco, Margaret Henry, Seetal Dodd, Geoffrey Nicholson, Mark Kotowicz, Michael Berk
OBJECTIVE: We aimed to report the prevalence, age-of-onset and comorbidity of mood and anxiety disorders in an age-stratified repr..
Does an increase in body mass index over 10 years affect knee structure in a population-based cohort study of adult women?
Sharon L Brennan, Flavia M Cicuttini, Julie A Pasco, Margaret J Henry, Yuanyuan Wang, Mark A Kotowicz, Geoff C Nicholson, Anita Wluka
INTRODUCTION: Although obesity is a modifiable risk factor for knee osteoarthritis (OA), the effect of weight gain on knee structu..
Lifetime psychiatric disorders and body composition: A population-based study
Lana J Williams, Julie A Pasco, Margaret J Henry, Felice N Jacka, Seetal Dodd, Geoffrey C Nicholson, Mark A Kotowicz, Michael Berk
BACKGROUND: This study aimed to investigate the relationship between depressive and anxiety disorders and indices of adiposity, in..