Bone size and bone turnover: relationship to fracture risk over ten years

Mood disorder and cancer onset: evidence from a population-based sample of Australian women

Stephanie P Cowdery, Amanda L Stuart, Julie A Pasco, Michael Berk, David Campbell, Ottar Bjerkeset, Lana J Williams

2021-07-01

OBJECTIVE: The role of mood disorders in cancer onset is unclear. The aim of this study was to investigate the association between..

Operational definitions of sarcopenia should consider depressive symptoms

Julie A Pasco, Sophia X Sui, Emma C West, Kara L Holloway‐Kew, Natalie K Hyde, Amanda L Stuart, James Gaston, Lana J Williams

2021-03-12

Dynapenia and Low Cognition: A Cross-Sectional Association in Postmenopausal Women

Julie A Pasco, Amanda L Stuart, Sophia X Sui, Kara L Holloway-Kew, Natalie K Hyde, Monica C Tembo, Pamela Rufus-Membere, Mark A Kotowicz, Lana J Williams

2021-01-01

Dynapenia is a key contributor to physical frailty. Cognitive impairment and dementia accompany frailty, yet links between skeleta..

Prevalence of Sarcopenia Employing Population-Specific Cut-Points: Cross-Sectional Data from the Geelong Osteoporosis Study, Australia

Sophia X Sui, Kara L Holloway-Kew, Natalie K Hyde, Lana J Williams, Monica C Tembo, Sarah Leach, Julie A Pasco

2021-01-01

BACKGROUND: Prevalence estimates for sarcopenia vary depending on the ascertainment criteria and thresholds applied. We aimed to e..

Physical and lifestyle factors associated with trabecular bone score values

Kara B Anderson, Kara L Holloway-Kew, Didier Hans, Mark A Kotowicz, Natalie K Hyde, Julie A Pasco

2020-11-08

TBS is associated with age, weight, childhood physical activity, and BMD in men and age, height, BMD, and mobility in women. INTRO..

Obesity and Brain Function: The Brain-Body Crosstalk

Sophia X Sui, Julie A Pasco

2020-10-01

Dementia comprises a wide range of progressive and acquired neurocognitive disorders. Obesity, defined as excessive body fat tissu..

Validity of self-reported cancer: Comparison between self-report versus cancer registry records in the Geelong Osteoporosis Study

Stephanie P Cowdery, Amanda L Stuart, Julie A Pasco, Michael Berk, David Campbell, Lana J Williams

2020-10-01

BACKGROUND: Determining the validity of self-reported data is important. The aim of this study was to assess the validity of self-..

Skeletal Muscle Density and Cognitive Function: A Cross-Sectional Study in Men

Sophia X Sui, Lana J Williams, Kara L Holloway-Kew, Natalie K Hyde, Kara B Anderson, Monica C Tembo, Alex B Addinsall, Sarah Leach, Julie A Pasco

2020-09-27

We aimed to investigate cross-sectional associations between skeletal muscle density, a proxy measure for fatty infiltration into ..

Total Antioxidant Capacity and Frailty in Older Men

Monica C Tembo, Kara L Holloway-Kew, Chiara C Bortolasci, Sophia X Sui, Sharon L Brennan-Olsen, Lana J Williams, Mark A Kotowicz, Julie A Pasco

2020-09-01

Frailty, a clinical syndrome characterized by multisystem dysregulation, has been associated with high levels of oxidative stress...

Prevalence of Frailty in Older Men and Women: Cross-Sectional Data from the Geelong Osteoporosis Study

Monica C Tembo, Kara L Holloway-Kew, Sophia X Sui, Trisha Dunning, Adrian CH Low, Shi-Jynn Yong, Boon L Ng, Sharon L Brennan-Olsen, Lana J Williams, Mark A Kotowicz, Julie A Pasco

2020-07-02

Few studies have investigated the prevalence of frailty in the Australian general population. This study determined the prevalence..

Muscle strength and gait speed rather than lean mass are better indicators for poor cognitive function in older men

Sophia X Sui, Kara L Holloway-Kew, Natalie K Hyde, Lana J Williams, Sarah Leach, Julie A Pasco

2020-06-25

We aimed to examine muscle strength, function and mass in relation to cognition in older men. This cross-sectional data-set includ..

The association between a fracture risk tool and frailty: Geelong Osteoporosis Study

Monica C Tembo, Kara L Holloway-Kew, Mohammadreza Mohebbi, Sophia X Sui, Sarah M Hosking, Sharon L Brennan-Olsen, Lana J Williams, Mark A Kotowicz, Julie A Pasco

2020-06-05

BACKGROUND: Frailty is characterised by age-related declines in physical, psychological and social functioning. Features of frailt..

Repurposing a fracture risk calculator (FRAX) as a screening tool for women at risk for sarcopenia

JA Pasco, M Mohebbi, MC Tembo, KL Holloway-Kew, NK Hyde, LJ Williams, MA Kotowicz

2020-03-17

Osteoporosis and sarcopenia share risk profiles, so we tested a fracture risk assessment tool (FRAX) as a screening tool for sarco..

Handgrip strength and muscle quality in Australian women: cross-sectional data from the Geelong Osteoporosis Study

Sophia X Sui, Kara L Holloway-Kew, Natalie K Hyde, Lana J Williams, Monica C Tembo, Mohammadreza Mohebbi, Marlene Gojanovic, Sarah Leach, Julie A Pasco

2020-02-15

BACKGROUND: Low handgrip strength (HGS) is a measure of poor skeletal muscle performance and a marker of ill health and frailty. M..

Lower-limb muscle strength: normative data from an observational population-based study

Julie A Pasco, Amanda L Stuart, Kara L Holloway-Kew, Monica C Tembo, Sophia X Sui, Kara B Anderson, Natalie K Hyde, Lana J Williams, Mark A Kotowicz

2020-02-08

BACKGROUND: The extent of muscle deterioration associated with ageing or disease can be quantified by comparison with appropriate ..

FRAX (Australia) scores in women with impaired fasting glucose and diabetes

Lelia LF de Abreu, Kara L Holloway-Kew, Muhammad A Sajjad, Mark A Kotowicz, Julie A Pasco

2019-12-01

Background: Diabetes is associated with higher fracture risk despite higher bone mineral density (BMD), with FRAX® underestimating..

Association between dairy intake and fracture in an Australian-based cohort of women: a prospective study

Hajara Aslam, Kara L Holloway-Kew, Mohammadreza Mohebbi, Felice N Jacka, Julie A Pasco

2019-11-01

OBJECTIVE: Given the inconsistent evidence on dairy consumption and risk of fracture, we assessed the association between milk/tot..

How well do the FRAX (Australia) and Garvan calculators predict incident fractures? Data from the Geelong Osteoporosis Study

KL Holloway-Kew, Y Zhang, AG Betson, KB Anderson, D Hans, K Hyde, GC Nicholson, NA Pocock, MA Kotowicz, JA Pasco

2019-10-01

This study reports that both FRAX and Garvan calculators underestimated fractures in Australian men and women, particularly in tho..

TOTAL ANTIOXIDANT CAPACITY AND FRAILTY IN OLDER MEN

MC Tembo, KL Holloway-Kew, CC Bortolasci, SX Sui, SL Brennan-Olsen, LJ Williams, MA Kotowicz, JA Pasco

2019-07-01

Bone Turnover Markers in Men and Women with Impaired Fasting Glucose and Diabetes

Kara L Holloway-Kew, Lelia LF De Abreu, Mark A Kotowicz, Muhammad A Sajjad, Julie A Pasco

2019-06-01

Bone turnover markers (BTMs) are reduced in diabetes, but whether BTM changes occur in impaired fasting glucose (IFG) is unknown. ..

Reference Ranges for Trabecular Bone Score in Australian Men and Women: A Cross-Sectional Study.

Kara B Anderson, Kara L Holloway-Kew, Didier Hans, Mark A Kotowicz, Natalie K Hyde, Julie A Pasco

2019-06-01

Trabecular bone score (TBS) is a novel method for indirectly assessing trabecular microarchitecture at the lumbar spine, providing..

Normative Data for Lean Mass Using FNIH Criteria in an Australian Setting

Julie A Pasco, Kara L Holloway-Kew, Monica C Tembo, Sophia X Sui, Kara B Anderson, Pamela Rufus-Membere, Natalie K Hyde, Lana J Williams, Mark A Kotowicz

2019-04-01

Recommendations from the FNIH Sarcopenia Project are that appendicular lean mass (ALM, kg) adjusted for body mass index (BMI, kg/m..

Fracture Risk in Women with Dysglycaemia: Assessing Effects of Baseline and Time-Varying Risk Factors

Lelia LF de Abreu, Kara L Holloway-Kew, Mohammadreza Mohebbi, Muhammad A Sajjad, Mark A Kotowicz, Julie A Pasco

2019-03-01

Although individuals with diabetes appear to have a higher fracture risk compared to those without diabetes, fracture risk in impa..

Prediction of major osteoporotic and hip fractures in Australian men using FRAX scores adjusted with trabecular bone score

KL Holloway, M Mohebbi, AG Betson, D Hans, NK Hyde, SL Brennan-Olsen, MA Kotowicz, JA Pasco

2018-01-01

There was no significant difference between the areas under receiver operating characteristics (AUROCs) and diagnostic indexes (se..

Trabecular Bone Score in Men and Women with Impaired Fasting Glucose and Diabetes

Kara L Holloway, Lelia LF De Abreu, Didier Hans, Mark A Kotowicz, Muhammad A Sajjad, Natalie K Hyde, Julie A Pasco

2018-01-01

Diabetes is associated with increased skeletal fragility, despite higher bone mineral density (BMD). Alternative measures are nece..

Personality disorder is an excess risk factor for physical multimorbidity among women with mental state disorders

Shae E Quirk, Amanda L Stuart, Michael Berk, Julie A Pasco, Sharon L Brennan Olsen, Heli Koivumaa-Honkanen, Risto Honkanen, Pyry S Lukkala, Andrew M Chanen, Mark Kotowicz, Lana J Williams

2017-11-01

We examined whether mental state disorders (lifetime mood, anxiety, eating, substance misuse) with comorbid personality disorder a..

Lower limb fracture presentations at a regional hospital

KL Holloway, D Yousif, G Bucki-Smith, S Hosking, AG Betson, LJ Williams, SL Brennan-Olsen, MA Kotowicz, A Sepetavc, JA Pasco

2017-08-28

We found that lower limb fractures, which were largely the result of minimal trauma, had high levels of hospitalisation, length of..

Musculoskeletal decline and mortality: prospective data from the Geelong Osteoporosis Study

Julie A Pasco, Mohammadreza Mohebbi, Kara L Holloway, Sharon L Brennan-Olsen, Natalie K Hyde, Mark A Kotowicz

2017-06-01

BACKGROUND: We aimed to examine the relationship between musculoskeletal deterioration and all-cause mortality in a cohort of wome..

All-Cause Mortality Risk in Australian Women with Impaired Fasting Glucose and Diabetes

Lelia LF de Abreu, Kara L Holloway, Mohammadreza Mohebbi, Muhammad A Sajjad, Mark A Kotowicz, Julie A Pasco

2017-01-01

AIMS: Impaired fasting glucose (IFG) and diabetes are increasing in prevalence worldwide and lead to serious health problems. The ..

A conduit between epidemiological research and regional health policy

Julie A Pasco, Chad Foulkes, Brianna Doolan, Kirsty Brown, Kara L Holloway, Sharon L Brennan-Olsen

2016-06-01

OBJECTIVE: To transform data from a research setting into a format that could be used to support strategies encouraging healthy li..

The addition of depression to the Framingham Risk Equation model for predicting coronary heart disease risk in women

Adrienne O'Neil, Aaron J Fisher, Katherine J Kibbey, Felice N Jacka, Mark A Kotowicz, Lana J Williams, Amanda L Stuart, Michael Berk, Paul A Lewandowski, John J Atherton, Craig B Taylor, Julie A Pasco

2016-06-01

BACKGROUND: Depression is widely considered to be an independent and robust predictor of Coronary Heart Disease (CHD), however is ..

Humeral Fractures in South-Eastern Australia: Epidemiology and Risk Factors

Kara L Holloway, Gosia Bucki-Smith, Amelia G Morse, Sharon L Brennan-Olsen, Mark A Kotowicz, David J Moloney, Kerrie M Sanders, Sam Korn, Elizabeth N Timney, Amelia G Dobbins, Julie A Pasco

2015-11-01

In this study, we report the epidemiology and risk factors for humeral fractures (proximal humerus and shaft) among men and women ..

Excessive daytime sleepiness and falls among older men and women: cross-sectional examination of a population-based sample

Amie C Hayley, Lana J Williams, Gerard A Kennedy, Kara L Holloway, Michael Berk, Sharon L Brennan-Olsen, Julie A Pasco

2015-07-05

BACKGROUND: Excessive daytime sleepiness (EDS) has been associated with an increased risk for falls among clinical samples of olde..

FRAX (Aus) and falls risk: Association in men and women

Kara L Holloway, Mark A Kotowicz, Stephen E Lane, Sharon L Brennan, Julie A Pasco

2015-07-01

PURPOSE: The WHO fracture risk prediction tool (FRAX®) utilises clinical risk factors to estimate the probability of fracture over..

Muscle strength and areal bone mineral density at the hip in women: a cross-sectional study

Julie A Pasco, Kara L Holloway, Sharon L Brennan-Olsen, David J Moloney, Mark A Kotowicz

2015-05-24

BACKGROUND: Muscle strengthening exercises are promoted for building and maintaining a healthy skeleton. We aimed to investigate t..

Psychiatric disorders, psychotropic medication use and falls among women: an observational study

Lana J Williams, Julie A Pasco, Amanda L Stuart, Felice N Jacka, Sharon L Brennan, Amelia G Dobbins, Risto Honkanen, Heli Koivumaa-Honkanen, Paivi H Rauma, Michael Berk

2015-04-08

BACKGROUND: Psychotropic agents known to cause sedation are associated with an increased risk of falls, but the role of psychiatri..

Age- and Sex-Related Patterns of First Fracture and Fracture Prevalence

Kara L Holloway, Sharon L Brennan, Mark A Kotowicz, Gosia Bucki-Smith, Amelia G Dobbins, Elizabeth N Timney, Lana J Williams, Julie A Pasco

2015-01-01

There are few data documenting the pattern of prevalent fracture across the entire adult age range, so we aimed to address this ga..

Dysglycaemia and Other Predictors for Progression or Regression from Impaired Fasting Glucose to Diabetes or Normoglycaemia

L de Abreu, Kara L Holloway, Mark A Kotowicz, Julie A Pasco

2015-01-01

AIMS: Diabetes mellitus is a growing health problem worldwide. This study aimed to describe dysglycaemia and determine the impact ..

Small area-level socioeconomic status and all-cause mortality within 10 years in a population-based cohort of women: Data from the Geelong Osteoporosis Study.

Sharon L Brennan-Olsen, Lana J Williams, Kara L Holloway, Sarah M Hosking, Amanda L Stuart, Amelia G Dobbins, Julie A Pasco

2015-01-01

BACKGROUND: The social gradient of health and mortality is well-documented. However, data are scarce regarding whether differences..

Total and Appendicular Lean Mass Reference Ranges for Australian Men and Women: The Geelong Osteoporosis Study

Haslinda Gould, Sharon L Brennan, Mark A Kotowicz, Geoffrey C Nicholson, Julie A Pasco

2014-04-01

The aim of this study was to develop reference ranges for total and appendicular lean mass measured using dual-energy X-ray absorp..

Fracture risk among older men: osteopenia and osteoporosis defined using cut-points derived from female versus male reference data

JA Pasco, SE Lane, SL Brennan, EN Timney, G Bucki-Smith, AG Dobbins, GC Nicholson, MA Kotowicz

2014-03-01

SUMMARY: We explored the effect of using male and female reference data in a male sample to categorise areal bone mineral density ..

Associations between measures of adiposity over 10 years and patella cartilage in population-based asymptomatic women

AJ Gunardi, SL Brennan, Y Wang, Flavia M Cicuttini, JA Pasco, MA Kotowicz, GC Nicholson, Anita Wluka

2013-12-01

OBJECTIVE: Osteoarthritis (OA) most commonly affects the patellofemoral compartment of the knee, and is a major cause of pain and ..

Cohort Profile: Geelong Osteoporosis Study

Julie A Pasco, Geoff C Nicholson, Mark A Kotowicz

2012-12-01

Nutrient intakes and the common mental disorders in women

Felice N Jacka, Michael Maes, Julie A Pasco, Lana J Williams, Michael Berk

2012-12-01

BACKGROUND: There is an increasing recognition of the role of nutrition in depression and anxiety. Magnesium, folate and zinc have..

Endogenous parathyroid hormone is associated with reduced cartilage volume in vivo in a population-based sample of adult women

Sharon Lee Brennan, Flavia M Cicuttini, Geoff C Nicholson, Julie A Pasco, Mark A Kotowicz, Anita Wluka

2012-06-01

OBJECTIVES: Animal and in vitro studies suggest that parathyroid hormone (PTH) may affect articular cartilage. However, little is ..

Bipolar disorder and adiposity: a study using whole body dual energy X-ray absorptiometry scans

Lana J Williams, Julie A Pasco, Felice N Jacka, Margaret J Henry, Seetal Dodd, Geoffrey C Nicholson, Mark A Kotowicz, Michael Berk

2011-10-01

Objective: Previous research has demonstrated a relationship between adiposity and bipolar disorder, although data are derived pre..

Bone mineral density is cross sectionally associated with cartilage volume in healthy, asymptomatic adult females: Geelong Osteoporosis Study

SL Brennan, JA Pasco, Flavia M Cicuttini, MJ Henry, MA Kotowicz, GC Nicholson, Anita Wluka

2011-10-01

INTRODUCTION: The association between osteoporosis and osteoarthritis (OA) is controversial. Although previous studies have shown ..

Changes in Hip Fracture Rates in Southeastern Australia Spanning the Period 1994-2007

Julie A Pasco, Sharon L Brennan, Margaret J Henry, Geoffrey C Nicholson, Kerrie M Sanders, Yu Zhang, Mark A Kotowicz

2011-07-01

Hip fracture incidence rates appear to be declining in Western populations. Utilizing comprehensive incident hip fracture data fro..

Paracetamol (acetaminophen) use, fracture and bone mineral density

Lana J Williams, Julie A Pasco, Margaret J Henry, Kerrie M Sanders, Geoffrey C Nicholson, Mark A Kotowicz, Michael Berk

2011-06-01

Paracetamol is the most widely prescribed simple analgesic and antipyretic. It exerts its effects via cyclooxygenase and endocanna..

Prevalence of mood and anxiety disorder in self reported irritable bowel syndrome (IBS). An epidemiological population based study of women

Arnstein Mykletun, Felice Jacka, Lana Williams, Julie Pasco, Margaret Henry, Geoffrey C Nicholson, Mark A Kotowicz, Michael Berk

2010-08-05

BACKGROUND: Irritable bowel syndrome (IBS) is commonly regarded as a functional disorder, and is hypothesized to be associated wit..

The prevalence of mood and anxiety disorders in Australian women

Lana Williams, Felice Jacka, Julie Pasco, Margaret Henry, Seetal Dodd, Geoffrey Nicholson, Mark Kotowicz, Michael Berk

2010-06-01

OBJECTIVE: We aimed to report the prevalence, age-of-onset and comorbidity of mood and anxiety disorders in an age-stratified repr..

Does an increase in body mass index over 10 years affect knee structure in a population-based cohort study of adult women?

Sharon L Brennan, Flavia M Cicuttini, Julie A Pasco, Margaret J Henry, Yuanyuan Wang, Mark A Kotowicz, Geoff C Nicholson, Anita Wluka

2010-01-01

INTRODUCTION: Although obesity is a modifiable risk factor for knee osteoarthritis (OA), the effect of weight gain on knee structu..

Lifetime psychiatric disorders and body composition: A population-based study

Lana J Williams, Julie A Pasco, Margaret J Henry, Felice N Jacka, Seetal Dodd, Geoffrey C Nicholson, Mark A Kotowicz, Michael Berk

2009-11-01

BACKGROUND: This study aimed to investigate the relationship between depressive and anxiety disorders and indices of adiposity, in..