Inhibitors of enzymes in the lysine biosynthetic pathway
Grant number: LX0345926
Recent reports of increasing bacterial resistance to antibiotics highlight the need for continual development of new antibacterial agents. Inhibitors of the biosynthesis of the amino acid lysine - an essential component of bacterial proteins and cell wall - may provide a novel class of antibiotics. This project describes investigations of the mechanism of the first two enzymes in the lysine biosynthetic pathway and the design and synthesis of inhibitors of these enzymes.
Related publications (2)
Conformationally constrained diketopimelic acid analogues as inhibitors of dihydrodipicolinate synthase
Berin A Boughton, Renwick CJ Dobson, Juliet A Gerrardc, Craig A Hutton
Dihydrodipicolinate synthase (DHDPS) is a key enzyme in lysine biosynthesis and a potential antibiotic target. The enzyme catalyse..
Two new irreversible inhibitors of dihydrodipicolinate synthase: diethyl (E,E)-4-oxo-2,5-heptadienedioate and diethyl (E)-4-oxo-2-heptenedioate
JJ Turner, JP Healy, RCJ Dobson, JA Gerrard, CA Hutton
Dihydrodipicolinate synthase (DHDPS) is a key enzyme in lysine biosynthesis and an important antibiotic target. The enzyme catalys..