Guidance molecules involved in the development of the enteric nervous system
Grant number: 350311
There are millions of nerve cells within the wall of the intestine, and they control many intestinal functions, including motility. During development, these nerve cells arise from cells which migrate away from the developing brain and first enter the stomach. The migratory cells are called 'neural crest' cells. After entering the stomach, neural crest cells migrate within the wall of the gastrointestinal tract, until they reach the far (anal) end. In embryonic mice, this colonisation of the entire gut by neural crest cells takes over four days, and in humans the process probably takes around three weeks. It is essential that neural crest cells colonise the entire gastrointestinal tract, sin..View full description
Related publications (2)
Effects of pharmacological inhibition of small GTPases on axon extension and migration of enteric neural crest-derived cells
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In the developing enteric nervous system, there is a close association between migrating neural crest-derived cells and the axons ..
Effects of different regions of the developing gut on the migration of enteric neural crest-derived cells: A role for Sema3A, but not Sema3F
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The enteric nervous system arises from vagal (caudal hindbrain) and sacral level neural crest-derived cells that migrate into and ..