Immunological prevention of cysticercosis and hydatid disease
Grant number: 350279
Cysticercosis and hydatid disease are caused by infections with the larval stages of tapeworm parasites. These infections cause substantial morbidity and mortality throughout the world, but particularly in developing countries. They are zoonotic diseases, being transmitted to humans from animals. This project aims to develop practical vaccines to assist with the prevention of both cysticercosis and hydatid disease in humans. The vaccines will be used in the parasites' natural animal hosts, thereby breaking the parasite life-cycle and preventing the diseases being passed to humans. Substantial preliminary research has been undertaken by the applicant, including completion of successful prelim..View full description
Related publications (27)
Validity of the Enzyme-linked Immunoelectrotransfer Blot (EITB) for naturally acquired porcine cysticercosis
Cesar M Jayashi, Armando E Gonzalez, Ricardo Castillo Neyra, Silvia Rodriguez, Hector H Garcia, Marshall W Lightowlers
The Enzyme-linked Immunoelectrotransfer Blot (EITB) has been used widely as a screening test for Taenia solium cysticercosis in sw..
Antigenic differences between the EG95-related proteins from Echinococcus granulosus G1 and G6 genotypes: implications for vaccination
CA Alvarez Rojas, CG Gauci, MW Lightowlers
Cystic echinococcosis caused by Echinococcus granulosus remains an important and neglected issue in public health. The study of th..
Characterisation of antibody responses in pigs induced by recombinant oncosphere antigens from Taenia solium
Cesar M Jayashi, Armando E Gonzalez, Ricardo Castillo Neyra, Craig T Kyngdon, Charles G Gauci, Marshall W Lightowlers
Recombinant antigens cloned from the oncosphere life cycle stage of the cestode parasite Taenia solium (T. solium) have been prove..
Maternal antibody parameters of cattle and calves receiving EG95 vaccine to protect against Echinococcus granulosus
David D Heath, Christine Robinson, Marshall W Lightowlers
Cattle may act as hosts for the transmission of the cestode parasite Echinococcus granulosus and play a role in transmission of th..
Successful immunization of naturally reared pigs against porcine cysticercosis with a recombinant oncosphere antigen vaccine
Cesar M Jayashi, Craig T Kyngdon, Charles G Gauci, Armando E Gonzalez, Marshall W Lightowlers
Taenia solium causes cysticercosis in pigs and taeniasis and neurocysticercosis in humans. Oncosphere antigens have proven to be e..
Seroprevalence and Risk Factors for Taenia solium Cysticercosis in Rural Pigs of Northern Peru
Cesar M Jayashi, Gianfranco Arroyo, Marshall W Lightowlers, Hector H Garcia, Silvia Rodriguez, Armando E Gonzalez
Taenia solium is a cestode parasite that causes cysticercosis in both humans and pigs. A serological survey was undertaken to asse..
Protection of pigs against Taenia solium cysticercosis by immunization with novel recombinant antigens
Charles G Gauci, Cesar M Jayashi, Armando E Gonzalez, Julia Lackenby, Marshall W Lightowlers
Recombinant antigens from the oncosphere stage of the parasite Taenia solium were expressed in Escherichia coli. The TSOL16, TSOL4..
Vaccination of bovines against Echinococcus granulosus (cystic echinococcosis)
David D Heath, Christine Robinson, Trevor Shakes, Yan Huang, Tursun Gulnur, Baoxing Shi, Zhuangzhi Zhang, Garry A Anderson, Marshall W Lightowlers
Hydatid disease is an important human zoonosis. Humans become infected from carnivores that are infected with the Echinococcus gra..
Strategies for Optimal Expression of Vaccine Antigens from Taeniid Cestode Parasites in Escherichia coli
Charles Gauci, David Jenkins, Marshall W Lightowlers
Investigations were undertaken into optimizing the expression of Cestode parasite vaccine antigens in the bacterium, Escherichia c..
Vaccines to combat the neglected tropical diseases
Jeffrey M Bethony, Rhea N Cole, Xiaoti Guo, Shaden Kamhawi, Marshall W Lightowlers, Alex Loukas, William Petri, Steven Reed, Jesus G Valenzuela, Peter J Hotez
The neglected tropical diseases (NTDs) represent a group of parasitic and related infectious diseases such as amebiasis, Chagas di..
Oncospheral Penetration Glands and Secretory Blebs Are the Sources of Taenia ovis Vaccine Antigens
Abdul Jabbar, Simon Crawford, Charles G Gauci, Anna K Walduck, Garry A Anderson, Marshall W Lightowlers
Taenia ovis is a cestode parasite infecting primarily sheep as intermediate hosts and dogs as definitive hosts. The first highly e..
Ultrastructural reconstruction of Taenia ovis oncospheres from serial sections
Abdul Jabbar, Simon Crawford, Daniel Mlocicki, Zdzislaw P Swiderski, David B Conn, Malcolm K Jones, Ian Beveridge, Marshall W Lightowlers
The cellular organisation of Taenia ovis oncospheres is interpreted from ultrathin serial sections and transmission electron micro..
Antibody responses to the host-protective Taenia solium oncosphere protein TSOL18 in pigs are directed against conformational epitopes
E Assana, CG Gauci, CT Kyngdon, AP Zoli, P Dorny, S Geerts, MW Lightowlers
TSOL18 is a recombinant protein that has been shown in repeated experimental trials to be capable of protecting pigs against chall..
Elimination of Taenia solium transmission to pigs in a field trial of the TSOL18 vaccine in Cameroon
Emmanuel Assana, Craig T Kyngdon, Charles G Gauci, Stanny Geerts, Pierre Dorny, Redgi De Deken, Garry A Anderson, Andre P Zoli, Marshall W Lightowlers
A pilot field trial of the TSOL18 vaccine was undertaken in Cameroon. Two hundred and forty, 2-3 month-old piglets were distribute..
Localisation of three host-protective oncospheral antigens of Taenia ovis
Abdul Jabbar, Craig T Kyngdon, Charles G Gauci, Anna K Walduck, Christina McCowan, Malcolm K Jones, Ian Beveridge, Marshall W Lightowlers
Immunohistochemistry, confocal immunofluorescence and immunogold labelling were used to determine the localisation of the host-pro..
Preliminary field trial of a vaccine against coenurosis caused by Taenia multiceps
A Varcasia, G Tosciri, GN Sanna Coccone, AP Pipia, G Garippa, A Scala, V Damien, G Vural, CG Gauci, MW Lightowlers
Taenia multiceps is a taeniid cestode that in its adult stage lives in the small intestine of dogs and other canids. In the interm..
Purification of polyclonal anti-conformational antibodies for use in affinity selection from random peptide phage display libraries: A study using the hydatid vaccine EG95
AJ Read, CG Gauci, MW Lightowlers
The use of polyclonal antibodies to screen random peptide phage display libraries often results in the recognition of a large numb..
Isolation of antibodies specific to a single conformation-dependant antigenic determinant on the EG95 hydatid vaccine
AJ Read, JL Casey, AM Coley, M Foley, CG Gauci, DC Jackson, MW Lightowlers
EG95 is a recombinant vaccine protein that elicits protection against hydatid disease in sheep. Previous studies have shown that t..
Echinococcus granulosus: Variability of the host-protective EG95 vaccine antigen in G6 and G7 genotypic variants
Conan Chow, Charles G Gauci, Gulay Vural, David J Jenkins, David D Heath, Mara C Rosenzvit, Majid Fasihi Harandi, Marshall W Lightowlers
Cystic hydatid disease in humans is caused by the zoonotic parasite Echinococcus granulosus. As an aid to control transmission of ..
Variability in the Echinococcus granulosus Cytochrome C oxidase 1 mitochondrial gene sequence from livestock in Turkey and a re-appraisal of the G1-3 genotype cluster
Gulay Vural, Aysel Unsal Baca, Charles G Gauci, O Bagci, Y Gicik, Marshall W Lightowlers
Investigations into the genetic strains of Echinococcus granulosus parasites occurring in sheep and cattle in Turkey were undertak..
Vaccination with recombinant oncosphere antigens reduces the susceptibility of sheep to infection with Taenia multiceps
Charles Gauci, Gulay Vural, Taraneh Oencel, Antonio Varcasia, Veronica Damian, Craig T Kyngdon, Philip S Craig, Garry A Anderson, Marshall W Lightowlers
Taenia multiceps is a cestode parasite, the larval stage of which encysts in the brain of sheep, goats and cattle causing an often..
Echinococcus multilocularis: Developmental stage-specific expression of Antigen B 8-kDa-subunits
Wulamu Mamuti, Yasuhito Sako, Ning Xiao, Kazuhiro Nakaya, Minoru Nakao, Hiroshi Yamasaki, Marshall W Lightowlers, Philip S Craig, Akira Ito
Antigen B (AgB) initially found in hydatid cyst fluid of Echinococcus granulosus is a polymeric lipoprotein of 160 kDa, and is an ..
In vitro oncosphere-killing assays to determine immunity to the larvae of Taenia pisiformis, Taenia ovis, Taenia saginata, and Taenia solium
CT Kyngdon, CG Gauci, RA Rolfe, JCV Guzman, MJF Salazar, MRV Pimentel, AE Gonzalez, HH Garcia, RH Gilman, RA Strugnell, MW Lightowlers
Taeniid cestodes infect humans and livestock, causing considerable morbidity and mortality, as well as economic loss. Substantial ..