Targeting calcineurin for improving muscle regeneration in skeletal muscle disease

Grant number: 350439

Abstract

Muscular dystrophy is a term that covers a diverse group of inherited disorders characterised by progressive muscle weakness and wasting. Duchenne muscular dystrophy (DMD) is the most severe form, caused by a lack of a protein called dystrophin, which renders muscles fragile, susceptible to damage, and with a compromised ability to regenerate or repair after injury. The disease progresses to all muscles and DMD patients are dependent on a wheelchair before their early teens and die in their twenties. There is a profound need for treatments that can ameliorate the dystrophic condition and improve patient quality of life. Restoring or increasing a muscle's capacity to regenerate would help imp..

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Related publications (6)

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Notexin causes greater myotoxic damage and slower functional repair in mouse skeletal muscles than bupivacaine

David R Plant, Fiona E Colarossi, Gordon S Lynch

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Although the myotoxins bupivacaine and notexin are employed for studying processes that regulate muscle regeneration after injury,..

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