Targeting calcineurin for improving muscle regeneration in skeletal muscle disease
Grant number: 350439
Muscular dystrophy is a term that covers a diverse group of inherited disorders characterised by progressive muscle weakness and wasting. Duchenne muscular dystrophy (DMD) is the most severe form, caused by a lack of a protein called dystrophin, which renders muscles fragile, susceptible to damage, and with a compromised ability to regenerate or repair after injury. The disease progresses to all muscles and DMD patients are dependent on a wheelchair before their early teens and die in their twenties. There is a profound need for treatments that can ameliorate the dystrophic condition and improve patient quality of life. Restoring or increasing a muscle's capacity to regenerate would help imp..View full description
Related publications (6)
Ageing prolongs inflammatory marker expression in regenerating rat skeletal muscles after injury
Chris van der Poel, Luc E Gosselin, Jonathan D Schertzer, James G Ryall, Kristy Swiderski, Meron Wondemaghen, Gordon S Lynch
BACKGROUND: Some of the most serious consequences of normal ageing relate to its effects on skeletal muscle, particularly signific..
Notexin causes greater myotoxic damage and slower functional repair in mouse skeletal muscles than bupivacaine
David R Plant, Fiona E Colarossi, Gordon S Lynch
Although the myotoxins bupivacaine and notexin are employed for studying processes that regulate muscle regeneration after injury,..
Activated calcineurin ameliorates contraction-induced injury to skeletal muscles of mdx dystrophic mice
Nicole Stupka, David R Plant, Jonathan D Schertzer, Tennent M Emerson, Rhonda Bassel-Duby, Eric N Olson, Gordon S Lynch
Utrophin expression is regulated by calcineurin and up-regulating utrophin can decrease the susceptibility of dystrophic skeletal ..
Differential calcineurin signalling activity and regeneration efficacy in diaphragm and limb muscles of dystrophic mdx mice
Nicole Stupka, Belinda J Michell, Bruce E Kemp, Gordon S Lynch
Calcineurin activity is essential for successful skeletal muscle regeneration in young mdx mice and in wild type mice following my..