NHMRC Research Fellowship

Alteration of the Thymic T Cell Repertoire by Rotavirus Infection Is Associated with Delayed Type 1 Diabetes Development in Non-Obese Diabetic Mice

Nicole L Webster, Christel Zufferey, Jessica A Pane, Barbara S Coulson

2013-03-15

Rotaviruses are implicated as a viral trigger for the acceleration of type 1 diabetes in children. Infection of adult non-obese di..

Rotavirus acceleration of murine type 1 diabetes is associated with a T helper 1-dependent specific serum antibody response and virus effects in regional lymph nodes

JA Pane, NL Webster, KL Graham, G Holloway, C Zufferey, BS Coulson

2013-03-01

AIMS/HYPOTHESIS: Rotavirus infection in at-risk children correlates with production of serum autoantibodies indicative of type 1 d..

Determinants of the Specificity of Rotavirus Interactions with the alpha 2 beta 1 Integrin

Fiona E Fleming, Kate L Graham, Yoshikazu Takada, Barbara S Coulson

2011-02-25

The human α2β1 integrin binds collagen and acts as a cellular receptor for rotaviruses and human echovirus 1. These ligands requir..

Rotavirus Antagonizes Cellular Antiviral Responses by Inhibiting the Nuclear Accumulation of STAT1, STAT2, and NF-kappa B

Gavan Holloway, Thanhmai T Truong, Barbara S Coulson

2009-05-15

A vital arm of the innate immune response to viral infection is the induction and subsequent antiviral effects of interferon (IFN)..

Rotavirus infection accelerates type 1 diabetes in mice with established insulitis

Kate L Graham, Natalie Sanders, Yan Tan, Janette Allison, Thomas WH Kay, Barbara S Coulson

2008-07-01

Infection modulates type 1 diabetes, a common autoimmune disease characterized by the destruction of insulin-producing islet beta ..

Crystallization and preliminary X-ray diffraction analysis of the carbohydrate-recognizing domain (VP8*) of bovine rotavirus strain NCDV

Xing Yu, Annabel Guillon, Alex J Szyczew, Milton J Kiefel, Barbara S Coulson, Mark von Itzstein, Helen Blanchard

2008-06-01

The infectivity of rotavirus is dramatically enhanced by proteolytic cleavage of its outer layer VP4 spike protein into two functi..

Rotavirus replication in intestinal cells differentially regulates integrin expression by a phosphatidylinositol 3-kinase-dependent pathway, resulting in increased cell adhesion and virus yield

Peter Halasz, Gavan Holloway, Stephen J Turner, Barbara S Coulson

2008-01-01

Changes in the interactions between intestinal cells and their surrounding environment during virus infection have not been well d..

Rotavirus infection of infant and young adult nonobese diabetic mice involves extraintestinal spread and delays diabetes onset

Kate L Graham, Joanne A O'Donnell, Yan Tan, Natalie Sanders, Emma M Carrington, Janette Allison, Barbara S Coulson

2007-06-01

Rotaviruses have been implicated as a possible viral trigger for exacerbations in islet autoimmunity, suggesting they might modula..

Rotavirus activates JNK and p38 signaling pathways in intestinal cells, leading to AP-1-driven transcriptional responses and enhanced virus replication

Gavan Holloway, Barbara S Coulson

2006-11-01

Rotavirus infection is known to regulate transcriptional changes in many cellular genes. The transcription factors NF-kappaB and A..