Chemical Synthesis of Bioactive Metabolites and Analogues From Marine Sources and Myxobacteria

Grant number: DP0556064

Abstract

This project could result in the production of a new type of anticancer compound. The proposal will study the synthesis of novel natural product analogues that could possess superior biological activities to the natural compounds. In addition, new chemistry may be developed which could be utilised to synthesise a number of related molecules.

Related publications (2)

Enantiospecific synthesis of the heparanase inhibitor ( )-trachyspic acid and stereoisomers from a common precursor

SC Zammit, V Ferro, E Hammond, MA Rizzacasa

2007-08-20

The total synthesis of natural (+)-trachyspic acid and its enantiomer is described starting from a common 2-deoxy-d-ribose derivat..

Synthesis of the C9-C29 fragments of ajudazols A and B

D Ganame, T Quach, C Poole, MA Rizzacasa

2007-08-13

The syntheses of both C9-C29 fragments 3 and 4 of the myxobacteria metabolites ajudazols A (1) and B (2) are described. The key st..

University of Melbourne Researchers

Mark Rizzacasa