The structural basis of the interaction of human relaxins with their receptors
Grant number: 350284
Human Gene 2 (H2) relaxin is a peptide hormone structurally related to insulin and has numerous biological actions related to its roles during pregnancy. It exerts these primarily by inducing the breakdown of collagen and the formation of new blood vessels while simultaneously stimulating tissue growth and inhibiting cell death. Its functions have led to several potential therapeutic roles for relaxin being explored. These include the treatment of fibrotic disorders and peripheral vascular disease. H2 relaxin is the principal expression product in vivo and has been shown to exert a wide range of physiological responses beyond those normally associated with pregnancy. We have recently discove..View full description
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Replacement of disulfide bonds with non-reducible isosteres can be a useful means of increasing the in vivo stability of a protein..
The Chemical Synthesis of Relaxin and Related Peptides A Historical Perspective
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Successful methods for the chemical assembly of insulin-like peptides allow the detailed study of their structure and function rel..
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Relaxin-3, a member of the insulin superfamily, is involved in regulating stress and feeding behavior. It is highly expressed in t..
Structure of the R3/I5 chimeric relaxin peptide, a selective GPCR135 and GPCR142 agonist
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The human relaxin family comprises seven peptide hormones with various biological functions mediated through interactions with G-p..
Synthesis, conformation, and activity of human insulin-like peptide 5 (INSL5)
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Insulin-like peptide 5 (INSL5) was first identified through searches of the expressed sequence tags (EST) databases. Primary seque..
The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors
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The relaxin peptides are a family of hormones that share a structural fold characterized by two chains, A and B, that are cross-br..
Regioselective disulfide solid phase synthesis, chemical characterization and in vitro receptor binding activity of equine relaxin
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In the equine industry, pregnancy loss during the third trimester constitutes a large percentage of fetal and neonatal mortality a..