Characterization of novel inhibitors of Gi-S phase progression in Drosophila
Grant number: 350369
Cancer is a disease that affects 1-3 people and therefore, understanding the mechanisms by which cancer arises is of major importance to medical science. Cancers arise through the accumulation of mutations that alter normal cell proliferation control, differentiation, cell death or cell movement. Many genes involved in cancer have been identified, however, there are likely to be many more genes, that when disrupted or misexpressed can lead to cancer. We are interested in the regulation of cell proliferation, and have been studying this in the genetically amenable animal model system, the vinegar fly, Drosophila. A key regulator of cell proliferation in all multicellular organisms is Cyclin E..View full description
Related publications (3)
In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1-Rok-Myosin-II and JNK signalling
Peytee Khoo, Kirsten Allan, Lee Willoughby, Anthony M Brumby, Helena E Richardson
The Ras oncogene contributes to ≈ 30% of human cancers, but alone is not sufficient for tumorigenesis. In a Drosophila screen for ..
Identification of Novel Ras-Cooperating Oncogenes in Drosophila melanogaster: A RhoGEF/Rho-Family/JNK Pathway Is a Central Driver of Tumorigenesis
Anthony M Brumby, Karen R Goulding, Tanja Schlosser, Sherene Loi, Ryan Galea, Peytee Khoo, Jessica E Bolden, Toshiro Aigaki, Patrick O Humbert, Helena E Richardson
We have shown previously that mutations in the apico-basal cell polarity regulators cooperate with oncogenic Ras (Ras(ACT)) to pro..
Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms
Nicola A Grzeschik, Linda M Parsons, Melinda L Allott, Kieran F Harvey, Helena E Richardson
BACKGROUND: The Drosophila neoplastic tumor suppressor Lethal (2) giant larvae (Lgl) controls apicobasal cell polarity and prolife..