Origin and regulation of vagal preganglionic neuron subtypes controlling airway smooth muscle tone
Grant number: 350333
The primary role of the airways is to allow the exchange of oxygen and carbon dioxide between the environment and the lungs. However, the airways are not merely a series of static tubes, but rather their size (or caliber) is subject to breath-by-breath alterations, thereby regulating gas exchange to match the body's demands. Regulation of airway caliber is achieved largely by subconscious changes in the tone of the muscle lining the airway wall. Airway muscle tone is primarily under the control of the parasympathetic division of the autonomic nervous system. Two distinct types of parasympathetic nerves innervate the airways: One type employs the neurotransmitter acetylcholine which causes ai..View full description
Related publications (6)
The effect of hyperpolarization-activated cyclic nucleotide-gated ion channel inhibitors on the vagal control of guinea pig airway smooth muscle tone
Alice E McGovern, Jed Robusto, Joanna Rakoczy, David G Simmons, Simon Phipps, Stuart B Mazzone
BACKGROUND AND PURPOSE: Subtypes of the hyperpolarization-activated cyclic nucleotide-gated (HCN) family of cation channels are wi..
Mapping supramedullary pathways involved in cough using functional brain imaging: Comparison with pain
Stuart B Mazzone, Alice E McGovern, Kendrick Koo, Michael J Farrell
Several indications suggest that supramedullary brain regions receive sensory information from the airways and provide motor contr..