Research Fellowship Renewal

Organ selective regulation of sympathetic outflow by the brain angiotensin system

R Ramchandra, ST Yao, CN May

2013-08-01

Angiotensin II (Ang II) has actions on the sympathetic nervous system both as a circulating hormone acting on the circumventricula..

The role of the paraventricular nucleus of the hypothalamus in the regulation of cardiac and renal sympathetic nerve activity in conscious normal and heart failure sheep

R Ramchandra, SG Hood, R Frithiof, MJ McKinley, CN May

2013-01-01

The paraventricular nucleus of the hypothalamus (PVN) plays a major role in central cardiovascular and volume control, and has bee..

Water soluble flavonol prodrugs that protect against ischaemia-reperfusion injury in rat hindlimb and sheep heart

SJ Williams, CJ Thomas, M Boujaoude, CT Gannon, SD Zanatta, B Jarrott, CN May, OL Woodman

2011-04-01

Phosphate and hemiadipate derivatives of cardioprotective flavonols are water soluble prodrugs that release superoxide scavenging ..

Response of cardiac sympathetic nerve activity to intravenous irbesartan in heart failure

R Ramchandra, AMD Watson, SG Hood, CN May

2010-04-01

To determine the effect of irbesartan treatment on resting levels and arterial baroreflex control of cardiac sympathetic nerve act..

Specific control of sympathetic nerve activity to the mammalian heart and kidney

CN May, R Frithiof, SG Hood, RM McAllen, MJ McKinley, R Ramchandra

2010-01-01

There is a large body of evidence indicating that sympathetic nerves to individual organs are specifically controlled, but only fe..

3′,4′-Dihydroxyflavonol improves post-ischaemic coronary endothelial function following 7 days reperfusion in sheep

S Wang, CJ Thomas, GJ Dusting, OL Woodman, CN May

2009-12-10

3′,4′-dihydroxyflavonol (DiOHF) is a potent antioxidant that reduces infarct size following myocardial ischaemia-reperfusion. Sinc..

Epidemiology of septic acute kidney injury

A Parmar, C Langenberg, L Wan, CN May, R Bellomo, SM Bagshaw

2009-12-01

The incidence of sepsis and acute kidney injury (AKI) is increasing in critically ill patients and both portend a higher risk of m..

Septic shock induces distinct changes in sympathetic nerve activity to the heart and kidney in conscious sheep

R Ramchandra, L Wan, SG Hood, R Frithiof, R Bellomo, CN May

2009-11-01

Sepsis and septic shock are the chief cause of death in intensive care units, with mortality rates between 30 and 70%. In a large ..

Discharge properties of cardiac and renal sympathetic nerves and their impaired responses to changes in blood volume in heart failure

R Ramchandra, SG Hood, R Frithiof, CN May

2009-09-01

Sympathetic nerve activity (SNA) consists of discharges that vary in amplitude and frequency, reflecting the level of recruitment ..

Hypothalamic paraventricular nucleus mediates sodium-induced changes in cardiovascular and renal function in conscious sheep

R Frithiof, R Ramchandra, S Hood, C May, M Rundgren

2009-07-01

The contribution of the paraventricular nucleus of the hypothalamus (PVN) in mediating cardiovascular, renal, hormonal, and sympat..

Basis for the preferential activation of cardiac sympathetic nerve activity in heart failure

R Ramchandra, SG Hood, DA Denton, RL Woods, MJ McKinley, RM McAllen, CN May

2009-01-20

In heart failure (HF) , sympathetic nerve activity is increased. Measurements in HF patients of cardiac norepinephrine spillover, ..

Angiotensin II in experimental hyperdynamic sepsis.

L Wan, C Langenberg, R Bellomo, CN May

2009-01-01

INTRODUCTION: Angiotensin II (Ang II) is a potential vasopressor treatment for hypotensive hyperdynamic sepsis. However, unlike ot..