DNA-TARGETED RADIOIMMUNOTHERAPHY/RADIOTHERAPHY & NUCLEAR MEDICINE
Grant number: 209125
Radioimmunotherapy is an experimental method of cancer treatment, involving the use of radioactive isotopes, which are targeted to tumour cells using specific molecules as carriers. These carriers are known as anti-tumour antibodies, and they bind specifically to tumour cells. Recent advances in molecular biology and in the understanding of the nature of tumour cells has resulted in the development of improved anti-tumour antibodies, and such improvements can be expected to continue. However, this project is concerned not with the tumour targeting aspect of radioimmunotherapy, but rather with the payload or cytotoxic mechanism, in which the radiation damage is focused on the DNA of the cell...View full description
Related publications (6)
Strand breakage by decay of DNA-bound I-124 provides a basis for combined PET imaging and Auger endoradiotherapy
Pavel Lobachevsky, George R Clark, Patrycja D Pytel, Brenda Leung, Colin Skene, Laura Andrau, Jonathan M White, Tom Karagiannis, Carleen Cullinane, Boon Q Lee, Andrew Stuchbery, Tibor Kibedi, Rodney J Hicks, Roger F Martin
Purpose DNA ligands labelled with 125I induce cytotoxic DNA double-strand breaks (DSB), suggesting a potential for Auger endoradio..
Plasmid breakage by I-125-labelled DNA ligands: Effect of DNA-iodine atom distance on breakage efficiency
Pavel N Lobachevsky, Joanne White, Melissa Leung, Colin Skene, Jonathan White, Roger F Martin
PURPOSE: The aim of the study is to establish the relationship between the efficiency of DNA double-stranded breakage by (125)I-la..
Plasmid DNA breakage by decay of DNA-associated auger electron emitters: Approaches to analysis of experimental data
PN Lobachevsky, TC Karagiannis, RF Martin
Plasmid DNA is a popular substrate for the assay of DNA strand breakage by a variety of agents. The use of the plasmid assay relie..