DNA-TARGETED RADIOIMMUNOTHERAPHY/RADIOTHERAPHY & NUCLEAR MEDICINE

Grant number: 209125

Abstract

Radioimmunotherapy is an experimental method of cancer treatment, involving the use of radioactive isotopes, which are targeted to tumour cells using specific molecules as carriers. These carriers are known as anti-tumour antibodies, and they bind specifically to tumour cells. Recent advances in molecular biology and in the understanding of the nature of tumour cells has resulted in the development of improved anti-tumour antibodies, and such improvements can be expected to continue. However, this project is concerned not with the tumour targeting aspect of radioimmunotherapy, but rather with the payload or cytotoxic mechanism, in which the radiation damage is focused on the DNA of the cell...

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Related publications (6)

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Strand breakage by decay of DNA-bound I-124 provides a basis for combined PET imaging and Auger endoradiotherapy

Pavel Lobachevsky, George R Clark, Patrycja D Pytel, Brenda Leung, Colin Skene, Laura Andrau, Jonathan M White, Tom Karagiannis, Carleen Cullinane, Boon Q Lee, Andrew Stuchbery, Tibor Kibedi, Rodney J Hicks, Roger F Martin

2016-11-01

Purpose DNA ligands labelled with 125I induce cytotoxic DNA double-strand breaks (DSB), suggesting a potential for Auger endoradio..

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Plasmid breakage by I-125-labelled DNA ligands: Effect of DNA-iodine atom distance on breakage efficiency

Pavel N Lobachevsky, Joanne White, Melissa Leung, Colin Skene, Jonathan White, Roger F Martin

2008-12-01

PURPOSE: The aim of the study is to establish the relationship between the efficiency of DNA double-stranded breakage by (125)I-la..

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Receptor-mediated DNA-targeted photoimmunotherapy

Tom C Karagiannis, Pavel N Lobachevsky, Brenda KY Leung, Jonathan M White, Roger F Martin

2006-11-01

We show the efficacy of a therapeutic strategy that combines the potency of a DNA-binding photosensitizer, UV(A)Sens, with the tum..

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DNA breakage by decay of Auger electron emitters: Experiments with I-123-iodoHoechst 33258 and plasmid DNA

PN Lobachevsky, RF Martin

2005-12-01

The Auger electron-emitting isotope 123I is of interest in the context of potential exploitation of Auger electron emitters in rad..

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RNA interference and potential therapeutic applications of short interfering RNAs

TC Karagiannis, A El-Osta

2005-10-01

RNA interference is an endogenous gene-silencing mechanism that involves double-stranded RNA-mediated sequence-specific mRNA degra..

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Plasmid DNA breakage by decay of DNA-associated auger electron emitters: Approaches to analysis of experimental data

PN Lobachevsky, TC Karagiannis, RF Martin

2004-07-01

Plasmid DNA is a popular substrate for the assay of DNA strand breakage by a variety of agents. The use of the plasmid assay relie..

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