PROGASTRIN DERIVED PEPTIDES: BIOLOGICAL ACTIVITIES AND FUNCTIONS IN THE GASTROINTESTINAL TRACT
Grant number: 350234
Gastrin is a hormone from the stomach which aids digestion by stimulating acid secretion. However too much acid can cause ulcers of the gastrointestinal tract. Gastrin also stimulates the growth of the lining of the stomach and intestines. This growth promoting effect is important for the development of the gastrointestinal tract before birth and may also be involved in a number of cancers especially colon cancer. Several different forms of gastrin are made by endocrine cells of the stomach and by cancers of the colon. It seems that the different types of gastrins have different effects and act through distinct receptors, but we do not know which are the most important forms and whether all ..View full description
Related publications (1)
The C-terminal flanking peptide (CTFP) of progastrin inhibits apoptosis via a PI3-kinase-dependent pathway
Oneel Patel, Kathryn M Marshall, Gianni Bramante, Graham S Baldwin, Arthur Shulkes
Progastrin is processed to a number of peptides including glycine-extended gastrin, amidated gastrin and the C-terminal flanking p..