CANCER FAMILY REGISTRIES FOR COLORECTAL CANCER (COLON CFRS)

Cumulative Burden of Colorectal Cancer Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer

Alexi N Archambault, Yu-Ru Su, Jihyoun Jeon, Minta Thomas, Yi Lin, David V Conti, Aung Ko Win, Lori C Sakoda, Iris Lansdorp-Vogelaar, Elisabeth FP Peterse, Ann G Zauber, David Duggan, Andreana N Holowatyj, Jeroen R Huyghe, Hermann Brenner, Michelle Cotterchio, Stephane Bezieau, Stephanie L Schmit, Christopher K Edlund, Melissa C Southey

2020-04-01

BACKGROUND & AIMS: Early-onset colorectal cancer (CRC, in persons younger than 50 years old) is increasing in incidence; yet, in t..

Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

Mev Dominguez-Valentin, Julian R Sampson, Toni T Seppala, Sanne W ten Broeke, John-Paul Plazzer, Sigve Nakken, Christoph Engel, Stefan Aretz, Mark A Jenkins, Lone Sunde, Inge Bernstein, Gabriel Capella, Francesc Balaguer, Huw Thomas, D Gareth Evans, John Burn, Marc Greenblatt, Eivind Hovig, Wouter H de Vos Tot Nederveen Cappel, Rolf H Sijmons

2020-01-01

PURPOSE: Pathogenic variants affecting MLH1, MSH2, MSH6, and PMS2 cause Lynch syndrome and result in different but imprecisely kno..

Systematic meta-analyses, field synopsis and global assessment of the evidence of genetic association studies in colorectal cancer.

Zahra Montazeri, Xue Li, Christine Nyiraneza, Xiangyu Ma, Maria Timofeeva, Victoria Svinti, Xiangrui Meng, Yazhou He, Yacong Bo, Samuel Morgan, Sergi Castellví-Bel, Clara Ruiz-Ponte, Ceres Fernández-Rozadilla, Ángel Carracedo, Antoni Castells, Timothy Bishop, Daniel Buchanan, Mark A Jenkins, Temitope O Keku, Annika Lindblom

2019-12-09

OBJECTIVE: To provide an understanding of the role of common genetic variations in colorectal cancer (CRC) risk, we report an upda..

Type 2 diabetes mellitus, blood cholesterol, triglyceride and colorectal cancer risk in Lynch syndrome

S Ghazaleh Dashti, Wing Yan Li, Daniel D Buchanan, Mark Clendenning, Christophe Rosty, Ingrid M Winship, Finlay A Macrae, Graham G Giles, Sheetal Hardikar, Xinwei Hua, Stephen N Thibodeau, Jane C Figueiredo, Graham Casey, Robert W Haile, Steven Gallinger, Loic Le Marchand, Polly A Newcomb, John D Potter, Noralane M Lindor, John L Hopper

2019-11-12

BACKGROUND: Type 2 diabetes mellitus and high total cholesterol and triglycerides are known to be associated with increased colore..

Ability of known susceptibility SNPs to predict colorectal cancer risk for persons with and without a family history

Mark A Jenkins, Aung K Win, James G Dowty, Robert J MacInnis, Enes Makalic, Daniel F Schmidt, Gillian S Dite, Mirosl Kapuscinski, Mark Clendenning, Christophe Rosty, Ingrid M Winship, Jon D Emery, Sibel Saya, Finlay A Macrae, Dennis J Ahnen, David Duggan, Jane C Figueiredo, Noralane M Lindor, Robert W Haile, John D Potter

2019-10-01

Before SNP-based risk can be incorporated in colorectal cancer (CRC) screening, the ability of these SNPs to estimate CRC risk for..

Physical activity and the risk of colorectal cancer in Lynch syndrome

S Ghazaleh Dashti, Aung Ko Win, Sheetal S Hardikar, Stephen E Glombicki, Sheila Mallenahalli, Selvi Thirumurthi, Susan K Peterson, Y Nancy You, Daniel D Buchanan, Jane C Figueiredo, Peter T Campbell, Steven Gallinger, Polly A Newcomb, John D Potter, Noralane M Lindor, Loic Le Marchand, Robert W Haile, John L Hopper, Mark A Jenkins, Karen M Basen-Engquist

2018-11-01

Cancer Risks for PMS2-Associated Lynch Syndrome

Sanne W ten Broeke, Heleen M van der Klift, Carli MJ Tops, Stefan Aretz, Inge Bernstein, Daniel D Buchanan, Albert de la Chapelle, Gabriel Capella, Mark Clendenning, Christoph Engel, Steven Gallinger, Encarna Gomez Garcia, Jane C Figueiredo, Robert Haile, Heather L Hampel, John L Hopper, Nicoline Hoogerbrugge, Magnus von Knebel Doeberitz, Loic Le Marchand, Tom GW Letteboer

2018-10-10

Risk of colorectal cancer for carriers of a germ-line mutation in POLE or POLD1

Daniel D Buchanan, Jenna R Stewart, Mark Clendenning, Christophe Rosty, Khalid Mahmood, Bernard J Pope, Mark A Jenkins, John L Hopper, Melissa C Southey, Finlay A Macrae, Ingrid M Winship, Aung Ko Win

2018-08-01

Cohort Profile: The Colon Cancer Family Registry Cohort (CCFRC)

Mark A Jenkins, Aung Ko Win, Allyson S Templeton, Maggie S Angelakos, Daniel D Buchanan, Michelle Cotterchio, Jane C Figueiredo, Stephen N Thibodeau, John A Baron, John D Potter, John L Hopper, Graham Casey, Steven Gallinger, Loic Le Marchand, Noralane M Lindor, Polly A Newcomb, Robert W Haile

2018-04-01

Genomic Characterization of Upper-Tract Urothelial Carcinoma in Patients With Lynch Syndrome

Timothy E Donahue, Aditya Bagrodia, Francois Audenet, Mark TA Donoghue, Eugene K Cha, John P Sfakianos, Dahlia Sperling, Hikmat Al-Ahmadie, Mark Clendenning, Christophe Rosty, Daniel D Buchanan, Mark Jenkins, John Hopper, Ingrid Winship, Allyson S Templeton, Michael F Walsh, Zsofia K Stadler, Gopa Iyer, Barry Taylor, Jonathan Coleman

2018-01-23

Somatic mutations of the coding microsatellites within the beta-2-microglobulin gene in mismatch repair-deficient colorectal cancers and adenomas

Mark Clendenning, Alvin Huang, Harindra Jayasekara, Marie Lorans, Susan Preston, Neil O'Callaghan, Bernard J Pope, Finlay A Macrae, Ingrid M Winship, Roger L Milne, Graham G Giles, Dallas R English, John L Hopper, Aung K Win, Mark A Jenkins, Melissa C Southey, Christophe Rosty, Daniel D Buchanan

2018-01-01

Targeted sequencing of 36 known or putative colorectal cancer susceptibility genes

Melissa S DeRycke, Shanaka Gunawardena, Jessica R Balcom, Angela M Pickart, Lindsey A Waltman, Amy J French, Shannon McDonnell, Shaun M Riska, Zachary C Fogarty, Melissa C Larson, Sumit Middha, Bruce W Eckloff, Yan W Asmann, Matthew J Ferber, Robert W Haile, Steven Gallinger, Mark Clendenning, Christophe Rosty, Aung K Win, Daniel D Buchanan

2017-09-01

Prediagnostic Alcohol Consumption and Colorectal Cancer Survival: The Colon Cancer Family Registry

Amanda I Phipps, Jamaica R Robinson, Peter T Campbell, Aung Ko Win, Jane C Figueiredo, Noralane M Lindor, Polly A Newcomb

2017-03-15

Germline miRNA DNA Variants and the Risk of Colorectal Cancer by Subtype

Noralane M Lindor, Melissa C Larson, Melissa S DeRycke, Shannon K McDonnell, Saurabh Baheti, Zachary C Fogarty, Aung Ko Win, John D Potter, Daniel D Buchanan, Mark Clendenning, Polly A Newcomb, Graham Casey, Steven Gallinger, Loic Le Marchand, John L Hopper, Mark A Jenkins, Ellen L Goode, Stephen N Thibodeau

2017-03-01

Modeling of Successive Cancer Risks in Lynch Syndrome Families in the Presence of Competing Risks Using Copulas

Yun-Hee Choi, Laurent Briollais, Aung K Win, John Hopper, Dan Buchanan, Mark Jenkins, Lajmi Lakhal-Chaieb

2017-03-01

Tumor testing to identify lynch syndrome in two Australian colorectal cancer cohorts

Daniel D Buchanan, Mark Clendenning, Christophe Rosty, Stine V Eriksen, Michael D Walsh, Rhiannon J Walters, Stephen N Thibodeau, Jenna Stewart, Susan Preston, Aung Ko Win, Louisa Flander, Driss Ait Ouakrim, Finlay A Macrae, Alex Boussioutas, Ingrid M Winship, Graham G Giles, John L Hopper, Melissa C Southey, Dallas English, Mark A Jenkins

2017-02-01

How does genetic risk information for Lynch syndrome translate to risk management behaviours?

Emma Steel, Andrew Robbins, Mark Jenkins, Louisa Flander, Clara Gaff, Louise Keogh

2017-01-05

SNP rs16906252C > T Is an Expression and Methylation Quantitative Trait Locus Associated with an Increased Risk of Developing MGMT-Methylated Colorectal Cancer

Joice Kuroiwa-Trzmielina, Fan Wang, Robert W Rapkins, Robyn L Ward, Daniel D Buchanan, Aung Ko Win, Mark Clendenning, Christophe Rosty, Melissa C Southey, Ingrid M Winship, John L Hopper, Mark A Jenkins, Jake Olivier, Nicholas J Hawkins, Megan P Hitchins

2016-12-15

Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer

Baiyu Yang, Aaron P Thrift, Jane C Figueiredo, Mark A Jenkins, Fredrick R Schumacher, David V Conti, Yi Lin, Aung Ko Win, Paul J Limburg, Sonja I Berndt, Hermann Brenner, Andrew T Chan, Jenny Chang-Claude, Michael Hoffmeister, Thomas J Hudson, Loic Le Marchand, Polly A Newcomb, Martha L Slattery, Emily White, Ulrike Peters

2016-10-01

Cholecystectomy and the risk of colorectal cancer by tumor mismatch repair deficiency status

Jie Shang, Jeanette C Reece, Daniel D Buchanan, Graham G Giles, Jane C Figueiredo, Graham Casey, Steven Gallinger, Stephen N Thibodeau, Noralane M Lindor, Polly A Newcomb, John D Potter, John A Baron, John L Hopper, Mark A Jenkins, Aung Ko Win

2016-08-01

Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer

David Jarvis, Jonathan S Mitchell, Philip J Law, Kimmo Palin, Sari Tuupanen, Alexandra Gylfe, Ulrika A Hanninen, Tatiana Cajuso, Tomas Tanskanen, Johanna Kondelin, Eevi Kaasinen, Antti-Pekka Sarin, Jaakko Kaprio, Johan G Eriksson, Harri Rissanen, Paul Knekt, Eero Pukkala, Pekka Jousilahti, Veikko Salomaa, Samuli Ripatti

2016-07-12

The Experience of Extended Bowel Resection in Individuals With a High Metachronous Colorectal Cancer Risk: A Qualitative Study

Emma J Steel, Alison H Trainer, Alexander G Heriot, Craig Lynch, Susan Parry, Aung K Win, Louise A Keogh

2016-07-01

Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease

Giulia Orlando, Philip J Law, Kimmo Palin, Sari Tuupanen, Alexandra Gylfe, Ulrika A Hanninen, Tatiana Cajuso, Tomas Tanskanen, Johanna Kondelin, Eevi Kaasinen, Antti-Pekka Sarin, Jaakko Kaprio, Johan G Eriksson, Harri Rissanen, Paul Knekt, Eero Pukkala, Pekka Jousilahti, Veikko Salomaa, Samuli Ripatti, Aarno Palotie

2016-06-01

Determining the familial risk distribution of colorectal cancer: a data mining approach

Rowena Chau, Mark A Jenkins, Daniel D Buchanan, Driss Ait Ouakrim, Graham G Giles, Graham Casey, Steven Gallinger, Robert W Haile, Loic Le Marchand, Polly A Newcomb, Noralane M Lindor, John L Hopper, Aung Ko Win

2016-04-01

GWASeq: targeted re-sequencing follow up to GWAS

Matthew P Salomon, Wai Lok Sibon Li, Christopher K Edlund, John Morrison, Barbara K Fortini, Aung Ko Win, David V Conti, Duncan C Thomas, David Duggan, Daniel D Buchanan, Mark A Jenkins, John L Hopper, Steven Gallinger, Loic Le Marchand, Polly A Newcomb, Graham Casey, Paul Marjoram

2016-03-03

Promoter methylation of ITF2, but not APC, is associated with microsatellite instability in two populations of colorectal cancer patients

Andrea J Savio, Darshana Daftary, Elizabeth Dicks, Daniel D Buchanan, Patrick S Parfrey, Joanne P Young, Daniel Weisenberger, Roger C Green, Steven Gallinger, John R McLaughlin, Julia A Knight, Bharati Bapat

2016-02-17

Germline mutations in PMS2 and MLH1 in individuals with solitary loss of PMS2 expression in colorectal carcinomas from the Colon Cancer Family Registry Cohort

Christophe Rosty, Mark Clendenning, Michael D Walsh, Stine V Eriksen, Melissa C Southey, Ingrid M Winship, Finlay A Macrae, Alex Boussioutas, Nicola K Poplawski, Susan Parry, Julie Arnold, Joanne P Young, Graham Casey, Robert W Haile, Steven Gallinger, Loic Le Marchand, Polly A Newcomb, John D Potter, Melissa DeRycke, Noralane M Lindor

2016-02-01

Clinicopathologic Risk Factor Distributions for MLH1 Promoter Region Methylation in CIMP-Positive Tumors

A Joan Levine, Amanda I Phipps, John A Baron, Daniel D Buchanan, Dennis J Ahnen, Stacey A Cohen, Noralane M Lindor, Polly A Newcomb, Christophe Rosty, Robert W Haile, Peter W Laird, Daniel J Weisenberger

2016-01-01

PMS2 monoallelic mutation carriers: the known unknown

McKinsey L Goodenberger, Brittany C Thomas, Douglas Riegert-Johnson, C Richard Boland, Sharon E Plon, Mark Clendenning, Aung Ko Win, Leigha Senter, Steven M Lipkin, Zsofia K Stadler, Finlay A Macrae, Henry T Lynch, Jeffrey N Weitzel, Albert de la Chapelle, Sapna Syngal, Patrick Lynch, Susan Parry, Mark A Jenkins, Steven Gallinger, Spring Holter

2016-01-01

Childhood cancers in families with and without Lynch syndrome

John A Heath, Jeanette C Reece, Daniel D Buchanan, Graham Casey, Carol A Durno, Steven Gallinger, Robert W Haile, Polly A Newcomb, John D Potter, Stephen N Thibodeau, Loic Le Marchand, Noralane M Lindor, John L Hopper, Mark A Jenkins, Aung Ko Win

2015-12-01

Lynch syndrome and cervical cancer

Yoland C Antill, James G Dowty, Aung Ko Win, Tina Thompson, Michael D Walsh, Margaret C Cummings, Steven Gallinger, Noralane M Lindor, Loic Le Marchand, John L Hopper, Polly A Newcomb, Robert W Haile, James Church, Katherine M Tucker, Daniel D Buchanan, Joanne P Young, Ingrid M Winship, Mark A Jenkins

2015-12-01

Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1

Timothy HT Cheng, Deborah Thompson, Jodie Painter, Tracy O'Mara, Maggie Gorman, Lynn Martin, Claire Palles, Angela Jones, Daniel D Buchanan, Aung Ko Win, John Hopper, Mark Jenkins, Noralane M Lindor, Polly A Newcomb, Steve Gallinger, David Conti, Fred Schumacher, Graham Casey, Graham G Giles, Paul Pharoah

2015-12-01

Risk of colorectal cancer for people with a mutation in both a MUTYH and a DNA mismatch repair gene

Aung Ko Win, Jeanette C Reece, Daniel D Buchanan, Mark Clendenning, Joanne P Young, Sean P Cleary, Hyeja Kim, Michelle Cotterchio, James G Dowty, Robert J MacInnis, Katherine M Tucker, Ingrid M Winship, Finlay A Macrae, Terrilea Burnett, Loic Le Marchand, Graham Casey, Robert W Haile, Polly A Newcomb, Stephen N Thibodeau, Noralane M Lindor

2015-12-01

A genome-wide association study for colorectal cancer identifies a risk locus in 14q23.1

Mathieu Lemire, Conghui Qu, Lenora WM Loo, Syed HE Zaidi, Hansong Wang, Sonja I Berndt, Stephane Bezieau, Hermann Brenner, Peter T Campbell, Andrew T Chan, Jenny Chang-Claude, Mengmeng Du, Christopher K Edlund, Steven Gallinger, Robert W Haile, Tabitha A Harrison, Michael Hoffmeister, John L Hopper, Lifang Hou, Li Hsu

2015-11-01

Genetic variants within the hTERT gene and the risk of colorectal cancer in Lynch syndrome.

Aung Ko Win, Mark Clendenning, William Crawford, Christophe Rosty, Susan G Preston, Melissa C Southey, Susan Parry, Graham G Giles, Finlay A Macrae, Ingrid M Winship, John A Baron, John L Hopper, Mark A Jenkins, Daniel D Buchanan

2015-11-01

Lynch syndrome is an inherited cancer-predisposing disorder caused by germline mutations in the DNA mismatch repair (MMR) genes bu..

Aspirin, Ibuprofen, and the Risk for Colorectal Cancer in Lynch Syndrome

Driss Ait Ouakrim, Seyedeh Ghazaleh Dashti, Rowena Chau, Daniel D Buchanan, Mark Clendenning, Christophe Rosty, Ingrid M Winship, Joanne P Young, Graham G Giles, Barbara Leggett, Finlay A Macrae, Dennis J Ahnen, Graham Casey, Steven Gallinger, Robert W Haile, Loic Le Marchand, Stephen N Thibodeau, Noralane M Lindor, Polly A Newcomb, John D Potter

2015-09-01

Fertility after young-onset colorectal cancer: a study of subjects with Lynch syndrome

D Stupart, AK Win, IM Winship, M Jenkins

2015-09-01

Identification of a common variant with potential pleiotropic effect on risk of inflammatory bowel disease and colorectal cancer

Hamed Khalili, Jian Gong, Hermann Brenner, Thomas R Austin, Carolyn M Hutter, Yoshifumi Baba, John A Baron, Sonja I Berndt, Stephane Bezieau, Bette Caan, Peter T Campbell, Jenny Chang-Claude, Stephen J Chanock, Constance Chen, Li Hsu, Shuo Jiao, David V Conti, David Duggan, Charles S Fuchs, Manish Gala

2015-09-01

Association between Body Mass Index and Mortality for Colorectal Cancer Survivors: Overall and by Tumor Molecular Phenotype

Peter T Campbell, Christina C Newton, Polly A Newcomb, Amanda I Phipps, Dennis J Ahnen, John A Baron, Daniel D Buchanan, Graham Casey, Sean P Cleary, Michelle Cotterchio, Alton B Farris, Jane C Figueiredo, Steven Gallinger, Roger C Green, Robert W Haile, John L Hopper, Mark A Jenkins, Loic Le Marchand, Karen W Makar, John R McLaughlin

2015-08-01

Female Hormonal Factors and the Risk of Endometrial Cancer in Lynch Syndrome

Seyedeh Ghazaleh Dashti, Rowena Chau, Driss Ait Ouakrim, Daniel D Buchanan, Mark Clendenning, Joanne P Young, Ingrid M Winship, Julie Arnold, Dennis J Ahnen, Robert W Haile, Graham Casey, Steven Gallinger, Stephen N Thibodeau, Noralane M Lindor, Loic Le Marchand, Polly A Newcomb, John D Potter, John A Baron, John L Hopper, Mark A Jenkins

2015-07-07

Mendelian Randomization Study of Body Mass Index and Colorectal Cancer Risk

Aaron P Thrift, Jian Gong, Ulrike Peters, Jenny Chang-Claude, Anja Rudolph, Martha L Slattery, Andrew T Chan, Adame Locke, Bratati Kahali, Anne E Justice, Tune H Pers, Steven Gallinger, Richard B Hayes, John A Baron, Bette J Caan, Shuji Ogino, Sonja I Berndt, Stephen J Chanock, Graham Casey, Robert W Haile

2015-07-01

Prediagnostic Physical Activity and Colorectal Cancer Survival: Overall and Stratified by Tumor Characteristics

Sheetal Hardikar, Polly A Newcomb, Peter T Campbell, Aung Ko Win, Noralane M Lindor, Daniel D Buchanan, Karen W Makar, Mark A Jenkins, John D Potter, Amanda I Phipps

2015-07-01

Germline TP53 Mutations in Patients With Early-Onset Colorectal Cancer in the Colon Cancer Family Registry

Matthew B Yurgelun, Serena Masciari, Victoria A Joshi, Rowena C Mercado, Noralane M Lindor, Steven Gallinger, John L Hopper, Mark A Jenkins, Daniel D Buchanan, Polly A Newcomb, John D Potter, Robert W Haile, Raju Kucherlapati, Sapna Syngal

2015-05-01

Mendelian randomization study of height and risk of colorectal cancer

Aaron P Thrift, Jian Gong, Ulrike Peters, Jenny Chang-Claude, Anja Rudolph, Martha L Slattery, Andrew T Chan, Tonu Esko, Andrew R Wood, Jian Yang, Sailaja Vedantam, Stefan Gustafsson, Tune H Pers, John A Baron, Stephane Bezieau, Sebastien Kuery, Shuji Ogino, Sonja I Berndt, Graham Casey, Robert W Haile

2015-04-01

Association of Aspirin and NSAID Use With Risk of Colorectal Cancer According to Genetic Variants

Hongmei Nan, Carolyn M Hutter, Yi Lin, Eric J Jacobs, Cornelia M Ulrich, Emily White, John A Baron, Sonja I Berndt, Hermann Brenner, Katja Butterbach, Bette J Caan, Peter T Campbell, Christopher S Carlson, Graham Casey, Jenny Chang-Claude, Stephen J Chanock, Michelle Cotterchio, David Duggan, Jane C Figueiredo, Charles S Fuchs

2015-03-17

Red Meat Intake, NAT2, and Risk of Colorectal Cancer: A Pooled Analysis of 11 Studies

Ashwin N Ananthakrishnan, Mengmeng Du, Sonja I Berndt, Hermann Brenner, Bette J Caan, Graham Casey, Jenny Chang-Claude, David Duggan, Charles S Fuchs, Steven Gallinger, Edward L Giovannucci, Tabitha A Harrison, Richard B Hayes, Michael Hoffmeister, John L Hopper, Lifang Hou, Li Hsu, Mark A Jenkins, Peter Kraft, Jing Ma

2015-01-01

Role of tumour molecular and pathology features to estimate colorectal cancer risk for first-degree relatives

Aung Ko Win, Daniel D Buchanan, Christophe Rosty, Robert J MacInnis, James G Dowty, Gillian S Dite, Graham G Giles, Melissa C Southey, Joanne P Young, Mark Clendenning, Michael D Walsh, Rhiannon J Walters, Alex Boussioutas, Thomas C Smyrk, Stephen N Thibodeau, John A Baron, John D Potter, Polly A Newcomb, Loic Le Marchand, Robert W Haile

2015-01-01

High prevalence of mismatch repair deficiency in prostate cancers diagnosed in mismatch repair gene mutation carriers from the colon cancer family registry

Christophe Rosty, Michael D Walsh, Noralane M Lindor, Stephen N Thibodeau, Erin Mundt, Steven Gallinger, Melyssa Aronson, Aaron Pollett, John A Baron, Sally Pearson, Mark Clendenning, Rhiannon J Walters, Belinda N Nagler, William J Crawford, Joanne P Young, Ingrid Winship, Aung Ko Win, John L Hopper, Mark A Jenkins, Daniel D Buchanan

2014-12-01

No Evidence of Gene-Calcium Interactions from Genome-Wide Analysis of Colorectal Cancer Risk

Mengmeng Du, Xuehong Zhang, Michael Hoffmeister, Robert E Schoen, John A Baron, Sonja I Berndt, Hermann Brenner, Christopher S Carlson, Graham Casey, Andrew T Chan, Keith R Curtis, David Duggan, W James Gauderman, Edward L Giovannucci, Jian Gong, Tabitha A Harrison, Richard B Hayes, Brian E Henderson, John L Hopper, Li Hsu

2014-12-01

Fertility and apparent genetic anticipation in Lynch syndrome

Douglas Stupart, Aung Ko Win, Mark Jenkins, Ingrid M Winship, Paul Goldberg, Rajkumar Ramesar

2014-09-01

Gene-Environment Interaction Involving Recently Identified Colorectal Cancer Susceptibility Loci

Elizabeth D Kantor, Carolyn M Hutter, Jessica Minnier, Sonja I Berndt, Hermann Brenner, Bette J Caan, Peter T Campbell, Christopher S Carlson, Graham Casey, Andrew T Chan, Jenny Chang-Claude, Stephen J Chanock, Michelle Cotterchio, Mengmeng Du, David Duggan, Charles S Fuchs, Edward L Giovannucci, Jian Gong, Tabitha A Harrison, Richard B Hayes

2014-09-01

Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis

Nicola Whiffin, Fay J Hosking, Susan M Farrington, Claire Palles, Sara E Dobbins, Lina Zgaga, Amy Lloyd, Ben Kinnersley, Maggie Gorman, Albert Tenesa, Peter Broderick, Yufei Wang, Ella Barclay, Caroline Hayward, Lynn Martin, Daniel D Buchanan, Aung Ko Win, John Hopper, Mark Jenkins, Noralane M Lindor

2014-09-01

Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A

Hansong Wang, Terrilea Burnett, Suminori Kono, Christopher A Haiman, Motoki Iwasaki, Lynne R Wilkens, Lenora WM Loo, David Van den Berg, Laurence N Kolonel, Brian E Henderson, Temitope O Keku, Robert S Sandler, Lisa B Signorello, William J Blot, Polly A Newcomb, Mala Pande, Christopher I Amos, Dee W West, Stephane Bezieau, Sonja I Berndt

2014-08-01

Characterisation of Familial Colorectal Cancer Type X, Lynch syndrome, and non-familial colorectal cancer

S Shiovitz, WK Copeland, MN Passarelli, AN Burnett-Hartman, WM Grady, JD Potter, S Gallinger, DD Buchanan, C Rosty, AK Win, M Jenkins, SN Thibodeau, R Haile, JA Baron, LL Marchand, PA Newcomb, NM Lindor

2014-07-29

Genetic Variation in UGT Genes Modify the Associations of NSAIDs with Risk of Colorectal Cancer: Colon Cancer Family Registry

Dominique Scherer, Lisel M Koepl, Elizabeth M Poole, Yesilda Balavarca, Liren Xiao, John A Baron, Li Hsu, Anna E Coghill, Peter T Campbell, Sarah E Kleinstein, Jane C Figueiredo, Johanna W Lampe, Katharina Buck, John D Potter, Richard J Kulmacz, Mark A Jenkins, John L Hopper, Aung K Win, Polly A Newcomb, Cornelia M Ulrich

2014-07-01

Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia

Iona Cheng, Jonathan M Kocarnik, Logan Dumitrescu, Noralane M Lindor, Jenny Chang-Claude, Christy L Avery, Christian P Caberto, Shelly-Ann Love, Martha L Slattery, Andrew T Chan, John A Baron, Lucia A Hindorff, Sungshim Lani Park, Fredrick R Schumacher, Michael Hoffmeister, Peter Kraft, Anne M Butler, David J Duggan, Lifang Hou, Chris S Carlson

2014-05-01

Risk of Colorectal Cancer for Carriers of Mutations in MUTYH, With and Without a Family History of Cancer

Aung Ko Win, James G Dowty, Sean P Cleary, Hyeja Kim, Daniel D Buchanan, Joanne P Young, Mark Clendenning, Christophe Rosty, Robert J MacInnis, Graham G Giles, Alex Boussioutas, Finlay A Macrae, Susan Parry, Jack Goldblatt, John A Baron, Terrilea Burnett, Loic Le Marchand, Polly A Newcomb, Robert W Haile, John L Hopper

2014-05-01

The Association of Telomere Length with Colorectal Cancer Differs by the Age of Cancer Onset

Lisa A Boardman, Kristin Litzelman, Songwon Seo, Ruth A Johnson, Russell J Vanderboom, Grace W Kimmel, Julie M Cunningham, Ronald E Gangnon, Corinne D Engelman, Douglas L Riegert-Johnson, John Potter, Robert Haile, Daniel Buchanan, Mark A Jenkins, David N Rider, Stephen N Thibodeau, Gloria M Petersen, Halcyon G Skinner

2014-03-01

Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database

Bryony A Thompson, Amanda B Spurdle, John-Paul Plazzer, Marc S Greenblatt, Kiwamu Akagi, Fahd Al-Mulla, Bharati Bapat, Inge Bernstein, Gabriel Capella, Johan T den Dunnen, Desiree du Sart, Aurelie Fabre, Michael P Farrell, Susan M Farrington, Ian M Frayling, Thierry Frebourg, David E Goldgar, Christopher D Heinen, Elke Holinski-Feder, Maija Kohonen-Corish

2014-02-01

Perceived Versus Predicted Risks of Colorectal Cancer and Self-Reported Colonoscopies by Members of Mismatch Repair Gene Mutation-Carrying Families Who Have Declined Genetic Testing

Louisa Flander, Andrew Speirs-Bridge, Alison Rutstein, Heather Niven, Aung Ko Win, Driss Ait Ouakrim, John L Hopper, Finlay Macrae, Louise Keogh, Clara Gaff, Mark Jenkins

2014-02-01

Genetic Predictors of Circulating 25-Hydroxyvitamin D and Risk of Colorectal Cancer

Linda T Hiraki, Conghui Qu, Carolyn M Hutter, John A Baron, Sonja I Berndt, Stephane Bezieau, Hermann Brenner, Bette J Caan, Graham Casey, Jenny Chang-Claude, Stephen J Chanock, David V Conti, David Duggan, Charles S Fuchs, Steven Gallinger, Edward L Giovannucci, Tabitha A Harrison, Richard B Hayes, Aditi Hazra, Brian Henderson

2013-11-01

Telomere Length Varies By DNA Extraction Method: Implications for Epidemiologic Research

Julie M Cunningham, Ruth A Johnson, Kristin Litzelman, Halcyon G Skinner, Songwon Seo, Corinne D Engelman, Russell J Vanderboom, Grace W Kimmel, Ronald E Gangnon, Douglas L Riegert-Johnson, John A Baron, John D Potter, Robert Haile, Daniel D Buchanan, Mark A Jenkins, David N Rider, Stephen N Thibodeau, Gloria M Petersen, Lisa A Boardman

2013-11-01

BRAFV600E Immunohistochemistry Facilitates Universal Screening of Colorectal Cancers for Lynch Syndrome

Christopher W Toon, Michael D Walsh, Angela Chou, David Capper, Adele Clarkson, Loretta Sioson, Stephen Clarke, Scott Mead, Rhiannon J Walters, Mark Clendenning, Christophe Rosty, Joanne P Young, Aung Ko Win, John L Hopper, Ashley Crook, Andreas von Deimling, Mark A Jenkins, Daniel D Buchanan, Anthony J Gill

2013-10-01

Detection of large scale 3 ' deletions in the PMS2 gene amongst Colon-CFR participants: have we been missing anything?

Mark Clendenning, Michael D Walsh, Judith Balmana Gelpi, Stephen N Thibodeau, Noralane Lindor, John D Potter, Polly Newcomb, Loic LeMarchand, Robert Haile, Steve Gallinger, John L Hopper, Mark A Jenkins, Christophe Rosty, Joanne P Young, Daniel D Buchanan

2013-09-01

Colon and Rectal Cancer Survival by Tumor Location and Microsatellite Instability: The Colon Cancer Family Registry

Amanda I Phipps, Noralane M Lindor, Mark A Jenkins, John A Baron, Aung Ko Win, Steven Gallinger, Robert Gryfe, Polly A Newcomb

2013-08-01

Germline HOXB13 p.Gly84Glu mutation and risk of colorectal cancer

Mohammad R Akbari, Laura N Anderson, Daniel D Buchanan, Mark Clendenning, Mark A Jenkins, Aung Ko Win, John L Hopper, Graham G Giles, Robert Nam, Steven Narod, Steven Gallinger, Sean P Cleary

2013-08-01

Association between hypermethylation of DNA repetitive elements in white blood cell DNA and early-onset colorectal cancer

Rhiannon J Walters, Elizabeth J Williamson, Dallas R English, Joanne P Young, Christophe Rosty, Mark Clendenning, Michael D Walsh, Susan Parry, Dennis J Ahnen, John A Baron, Aung Ko Win, Graham G Giles, John L Hopper, Mark A Jenkins, Daniel D Buchanan

2013-07-01

Absence of PMS2 mutations in colon-CFR participants whose colorectal cancers demonstrate unexplained loss of MLH1 expression

M Clendenning, FA Macrae, MD Walsh, RJ Walters, SN Thibodeau, SR Gunawardena, JD Potter, RW Haile, S Gallinger, JL Hopper, MA Jenkins, C Rosty, JP Young, DD Buchanan

2013-06-01

Risk of Metachronous Colon Cancer Following Surgery for Rectal Cancer in Mismatch Repair Gene Mutation Carriers

Aung Ko Win, Susan Parry, Bryan Parry, Matthew F Kalady, Finlay A Macrae, Dennis J Ahnen, Graeme P Young, Lara Lipton, Ingrid Winship, Alex Boussioutas, Joanne P Young, Daniel D Buchanan, Julie Arnold, Loic Le Marchand, Polly A Newcomb, Robert W Haile, Noralane M Lindor, Steven Gallinger, John L Hopper, Mark A Jenkins

2013-06-01

Genetic Variations in SMAD7 Are Associated with Colorectal Cancer Risk in the Colon Cancer Family Registry

Xuejuan Jiang, J Esteban Castelao, David Vandenberg, Angel Carracedo, Carmen M Redondo, David V Conti, Jesus P Paredes Cotore, John D Potter, Polly A Newcomb, Michael N Passarelli, Mark A Jenkins, John L Hopper, Steven Gallinger, Loic Le Marchand, Maria E Martinez, Dennis J Ahnen, John A Baron, Noralane M Lindor, Robert W Haile, Manuela Gago-Dominguez

2013-04-03

Cancer Risks for MLH1 and MSH2 Mutation Carriers

James G Dowty, Aung K Win, Daniel D Buchanan, Noralane M Lindor, Finlay A Macrae, Mark Clendenning, Yoland C Antill, Stephen N Thibodeau, Graham Casey, Steve Gallinger, Loic Le Marchand, Polly A Newcomb, Robert W Haile, Graeme P Young, Paul A James, Graham G Giles, Shanaka R Gunawardena, Barbara A Leggett, Michael Gattas, Alex Boussioutas

2013-03-01

Multiplicity and Molecular Heterogeneity of Colorectal Carcinomas in Individuals With Serrated Polyposis

Christophe Rosty, Michael D Walsh, Rhiannon J Walters, Mark Clendenning, Sally-Ann Pearson, Mark A Jenkins, Aung Ko Win, John L Hopper, Kevin Sweet, Wendy L Frankel, Melyssa Aronson, Steve Gallinger, Jack Goldblatt, Kathy Tucker, Sian Greening, Michael R Gattas, Sonja Woodall, Julie Arnold, Neal I Walker, Susan Parry

2013-03-01

Risks of Colorectal and Other Cancers After Endometrial Cancer for Women With Lynch Syndrome

Aung Ko Win, Noralane M Lindor, Ingrid Winship, Katherine M Tucker, Daniel D Buchanan, Joanne P Young, Christophe Rosty, Barbara Leggett, Graham G Giles, Jack Goldblatt, Finlay A Macrae, Susan Parry, Matthew F Kalady, John A Baron, Dennis J Ahnen, Loic Le Marchand, Steven Gallinger, Robert W Haile, Polly A Newcomb, John L Hopper

2013-02-01

A Multifactorial Likelihood Model for MMR Gene Variant Classification Incorporating Probabilities Based on Sequence Bioinformatics and Tumor Characteristics: A Report from the Colon Cancer Family Registry

Bryony A Thompson, David E Goldgar, Carol Paterson, Mark Clendenning, Rhiannon Walters, Sven Arnold, Michael T Parsons, Michael D Walsh, Steven Gallinger, Robert W Haile, John L Hopper, Mark A Jenkins, Loic LeMarchand, Noralane M Lindor, Polly A Newcomb, Stephen N Thibodeau, Joanne P Young, Daniel D Buchanan, Sean V Tavtigian, Amanda B Spurdle

2013-01-01

The Australasian Colorectal Cancer Family Registry Reducing the impact of colorectal cancer

Ingrid Winship, Aung Ko Win

2012-11-05

Risks of Primary Extracolonic Cancers Following Colorectal Cancer in Lynch Syndrome

Aung Ko Win, Noralane M Lindor, Joanne P Young, Finlay A Macrae, Graeme P Young, Elizabeth Williamson, Susan Parry, Jack Goldblatt, Lara Lipton, Ingrid Winship, Barbara Leggett, Katherine M Tucker, Graham G Giles, Daniel D Buchanan, Mark Clendenning, Christophe Rosty, Julie Arnold, A Joan Levine, Robert W Haile, Steven Gallinger

2012-09-01

Colorectal Cancer Linkage on Chromosomes 4q21, 8q13, 12q24, and 15q22

Mine S Cicek, Julie M Cunningham, Brooke L Fridley, Daniel J Serie, William R Bamlet, Brenda Diergaarde, Robert W Haile, Loic Le Marchand, Theodore G Krontiris, H Banfield Younghusband, Steven Gallinger, Polly A Newcomb, John L Hopper, Mark A Jenkins, Graham Casey, Fredrick Schumacher, Zhu Chen, Melissa S DeRycke, Allyson S Templeton, Ingrid Winship

2012-05-31

Cancer Risks for the Relatives of Colorectal Cancer Cases with a Methylated MLH1 Promoter Region: Data from the Colorectal Cancer Family Registry

A Joan Levine, Aung Ko Win, Daniel D Buchanan, Mark A Jenkins, John A Baron, Joanne P Young, Tiffany I Long, Daniel J Weisenberger, Peter W Laird, Rebecca L McCall, David J Duggan, Robert W Haile

2012-02-01

Meta-analysis of new genome-wide association studies of colorectal cancer risk

Ulrike Peters, Carolyn M Hutter, Li Hsu, Fredrick R Schumacher, David V Conti, Christopher S Carlson, Christopher K Edlund, Robert W Haile, Steven Gallinger, Brent W Zanke, Mathieu Lemire, Jagadish Rangrej, Raakhee Vijayaraghavan, Andrew T Chan, Aditi Hazra, David J Hunter, Jing Ma, Charles S Fuchs, Edward L Giovannucci, Peter Kraft

2012-02-01

Cancer risks for monoallelic MUTYH mutation carriers with a family history of colorectal cancer

Aung Ko Win, Sean P Cleary, James G Dowty, John A Baron, Joanne P Young, Daniel D Buchanan, Melissa C Southey, Terrilea Burnett, Patrick S Parfrey, Roger C Green, Loic Le Marchand, Polly A Newcomb, Robert W Haile, Noralane M Lindor, John L Hopper, Steven Gallinger, Mark A Jenkins

2011-11-01

Determining the frequency of de novo germline mutations in DNA mismatch repair genes

Aung Ko Win, Mark A Jenkins, Daniel D Buchanan, Mark Clendenning, Joanne P Young, Graham G Giles, Jack Goldblatt, Barbara A Leggett, John L Hopper, Stephen N Thibodeau, Noralane M Lindor

2011-08-01

Genotype-Environment Interactions in Microsatellite Stable/Microsatellite Instability-Low Colorectal Cancer: Results from a Genome-Wide Association Study

Jane C Figueiredo, Juan Pablo Lewinger, Chi Song, Peter T Campbell, David V Conti, Christopher K Edlund, Dave J Duggan, Jagadish Rangrej, Mathieu Lemire, Thomas Hudson, Brent Zanke, Michelle Cotterchio, Steven Gallinger, Mark Jenkins, John Hopper, Robert Haile, Polly Newcomb, John Potter, John A Baron, Loic Le Marchand

2011-05-01

Body Mass Index in Early Adulthood and Endometrial Cancer Risk for Mismatch Repair Gene Mutation Carriers

Aung Ko Win, James G Dowty, Yoland C Antill, Dallas R English, John A Baron, Joanne P Young, Graham G Giles, Melissa C Southey, Ingrid Winship, Lara Lipton, Susan Parry, Stephen N Thibodeau, Robert W Haile, Steven Gallinger, Loic Le Marchand, Noralane M Lindor, Polly A Newcomb, John L Hopper, Mark A Jenkins

2011-04-01

Dependence of Colorectal Cancer Risk on the Parent-of-Origin of Mutations in DNA Mismatch Repair Genes

Christine M van Vliet, James G Dowty, Jane L van Vliet, Letitia Smith, Leeanne J Mead, Finlay A Macrae, D James B St John, Graham G Giles, Melissa C Southey, Mark A Jenkins, Gary M Velan, John L Hopper

2011-02-01

The role of SMAD4 in early-onset colorectal cancer

SG Royce, K Alsop, A Haydon, L Mead, LD Smith, AA Tesoriero, GG Giles, MA Jenkins, JL Hopper, MC Southey

2010-03-01