THE BIOLOGY OF GASTRIN-FERRIC ION COMPLEXES

Grant number: 400062

Abstract

The objective of this project is to understand the biological significance of the complex between ferric ions and non-amidated gastrins (NAGs). This laboratory has shown that NAGs selectively bind 2 ferric ions, and that ferric ion binding is essential for biological activity. Our unpublished data in mouse models indicates a previously unsuspected reciprocal relationship between plasma NAG concentrations and iron status. The significance of this project to human health lies in the facts that NAGs act as growth factors for the normal gastric and colonic mucosa, accelerate the development of both gastric and colorectal cancer, and may be involved in iron overload. The specific aims are: (1) to..

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Related publications (13)

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High Affinity Binding of Indium and Ruthenium Ions by Gastrins

Graham S Baldwin, Graham N George, M Jake Pushie

2015-10-12

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Activation of Src family tyrosine kinases by ferric ions

Graham S Baldwin, Daisy Sio-Seng Lio, Audrey Ferrand, Bruno Catimel, B Philip Shehan, Raymond S Norton, Heung-Chin Cheng

2014-03-01

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Bismuth ions inhibit the biological activity of non-amidated gastrins in vivo

Suzana Kovac, Su-Wen Loh, Shamilah Lachal, Arthur Shulkes, Graham S Baldwin

2012-02-15

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Gastrins, iron homeostasis and colorectal cancer

Suzana Kovac, Gregory J Anderson, Graham S Baldwin

2011-05-01

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Ferric ions inhibit proteolytic processing of progastrin

Gianni Bramante, Oneel Patel, Arthur Shulkes, Graham S Baldwin

2011-01-28

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Definition of the residues required for the interaction between glycine-extended gastrin and transferrin in vitro

Suzana Kovac, Audrey Ferrand, Jean-Pierre Esteve, Anne B Mason, Graham S Baldwin

2009-09-01

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Expression of gastrin precursors by CD133-positive colorectal cancer cells is crucial for tumour growth

Audrey Ferrand, Mauro S Sandrin, Arthur Shulkes, Graham S Baldwin

2009-03-01

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Phosphorylation of cyclin-dependent kinase 2 peptides enhances metal binding

Graham S Baldwin

2009-01-30

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Gastrins, iron and colorectal cancer

Graham S Baldwin

2009-01-01

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Tyrosine modification enhances metal-ion binding

Graham S Baldwin, Michael F Bailey, B Philip Shehan, Loulia Sims, Raymond S Norton

2008-11-15

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PAK1 interacts with beta-catenin and is required for the regulation of the beta-catenin signalling pathway by gastrins

Hong He, Arthur Shulkes, Graham S Baldwin

2008-10-01

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Preparation and properties of recombinant rat and human procholecystokinin(57-95)

Susann Friedrich, Yulia Sims, Graham S Baldwin

2008-04-01

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Involvement of G proteins of the Rho family in the regulation of Bcl-2-like protein expression and caspase 3 activation by Gastrins

Hong He, Mildred Yim, Kevin H Liu, Stephen C Cody, Arthur Shulkes, Graham S Baldwin

2008-01-01