Novel modes of regulating serotonin 5HT2c receptors.
Grant number: 400133
The normal function of all living cells depends on how they respond to the multitude of physical and chemical stimuli to which they are constantly exposed. The majority of these stimuli acting on cells do so not by directly entering the cells, but rather by acting on specific types of receiver proteins on the cell's surface that are called receptors. The most important family of cell-surface receptors transmit their message to the inside of the cell by coupling to yet another type of protein known as a G protein, and are therefore commonly referred to as G protein-coupled receptors (or GPCRs). The current proposal focuses on a special family of GPCRs that mediate the actions of the neurochem..View full description