Elucidation Of Trafficking Of The Menkes (Mnk;Atp7a) Copper-Transporting Atpase In Epthelial Cells

Abstract

Copper is an essential trace element for all organisms. Copper is needed for many processes including energy metabolism, the making and maintenance of strong bones and arteries with sufficient elasticity, the synthesis of chemical transmitters in the brain and for the reactions which remove toxic free radicals. Copper is also used by the proteins involved in important neurological diseases including Alzheimers disease and mad cow disease. Menkes disease is an inherited and usually lethal copper deficiency disorder in humans, and the diverse and detrimental symptoms of this disease related to organs and tissues described above is a stark indicator of the essentiality of copper. We have carrie..

Related publications (1)

GENE AMPLIFICATION OF THE MENKES (MNK, ATP7A) P-TYPE ATPASE GENE OF CHO CELLS IS ASSOCIATED WITH COPPER RESISTANCE AND ENHANCED COPPER EFFLUX

J CAMAKARIS, MJ PETRIS, L BAILEY, PY SHEN, P LOCKHART, TW GLOVER, CL BARCROFT, J PATTON, JFB MERCER

1995-11-01