Characterisation of cooperation between cell polarity regulators and oncogenes in tumourigenesis using Drosophila
Grant number: 400211
Cancers affect 1-3 people at some stage during their lifetime and therefore is of major importance to medical science. Cancers arise through the accumulation of mutations that alter normal cell proliferation control, differentiation, cell death or cell movement. In addition, recent studies have shown that the tumour environment (the interaction between cells) can be a major factor in the development of the cancer. However, this is difficult to study in mammalian models. In this proposal we use the genetically amenable, model system, the vinegar fly Drosophila, to investigate the development of tumours using defined mutations. To explore mechanisms of tumourigenesis in Drosophila, we are usin..View full description
Related publications (5)
Cooperation of the BTB-Zinc finger protein, Abrupt, with cytoskeletal regulators in Drosophila epithelial tumorigenesis
Nezaket Turkel, Marta Portela, Carole Poon, Jason Li, Anthony M Brumby, Helena E Richardson
The deregulation of cell polarity or cytoskeletal regulators is a common occurrence in human epithelial cancers. Moreover, there i..
BTB-Zinc Finger Oncogenes Are Required for Ras and Notch-Driven Tumorigenesis in Drosophila
Karen Doggett, Nezaket Turkel, Lee F Willoughby, Jason Ellul, Michael J Murray, Helena E Richardson, Anthony M Brumby
During tumorigenesis, pathways that promote the epithelial-to-mesenchymal transition (EMT) can both facilitate metastasis and endo..
The BTB-zinc Finger Transcription Factor Abrupt Acts as an Epithelial Oncogene in Drosophila melanogaster through Maintaining a Progenitor-like Cell State
Nezaket Turkel, Virender K Sahota, Jessica E Bolden, Karen R Goulding, Karen Doggett, Lee F Willoughby, Enrique Blanco, Enrique Martin-Blanco, Montserrat Corominas, Jason Ellul, Toshiro Aigaki, Helena E Richardson, Anthony M Brumby
The capacity of tumour cells to maintain continual overgrowth potential has been linked to the commandeering of normal self-renewa..
In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1-Rok-Myosin-II and JNK signalling
Peytee Khoo, Kirsten Allan, Lee Willoughby, Anthony M Brumby, Helena E Richardson
The Ras oncogene contributes to ≈ 30% of human cancers, but alone is not sufficient for tumorigenesis. In a Drosophila screen for ..
Identification of Novel Ras-Cooperating Oncogenes in Drosophila melanogaster: A RhoGEF/Rho-Family/JNK Pathway Is a Central Driver of Tumorigenesis
Anthony M Brumby, Karen R Goulding, Tanja Schlosser, Sherene Loi, Ryan Galea, Peytee Khoo, Jessica E Bolden, Toshiro Aigaki, Patrick O Humbert, Helena E Richardson
We have shown previously that mutations in the apico-basal cell polarity regulators cooperate with oncogenic Ras (Ras(ACT)) to pro..