Modulation of Neurotrophin Receptor Signaling: Understanding the Determinants and Phenotypic Consequences.
Grant number: 400341
Abstract
Peripheral nerves are complex structures consisting of motor and sensory neurons, their axons, and the cells that support them, Schwann cells. Peripheral neuropathy is a common neurological problem which covers many disorders of the peripheral nervous system. There are predominately two types of neuropathies: those where there is a primary loss or degeneration of neurons and-or their axons; and those where the Schwann cells are lost. These degenerative pathologies have prompted interest in the potential of growth factors as a general therapy for peripheral neuropathy. The neurotrophins are a family of neuronal growth factors that influence many key aspects of neuronal development, as well as..
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