Research Fellowship

Isoform specific differences in phospholipase C beta 1 expression in the prefrontal cortex in schizophrenia and suicide

M Udawela, E Scarr, S Boer, JY Um, AJ Hannan, C McOmish, CC Felder, EA Thomas, B Dean

2017-12-01

Our previous study demonstrated that phospholipase C beta 1 mRNA was down-regulated in Brodmann's area 46 from subjects with schiz..

Understanding the pathophysiology of schizophrenia: Contributions from the Melbourne Psychiatric Brain Bank

B Dean, D Copolov, E Scarr

2016-11-01

The Melbourne Psychiatric Brain Bank came into existence 25 years ago. This review focusses on lines of research that have used ti..

An investigation of the factors that regulate muscarinic receptor expression in schizophrenia

MS Seo, E Scarr, B Dean

2014-01-01

We previously identified a group of subjects with schizophrenia who, on average, have a 75% decrease in cholinergic receptor, musc..

Phospholipase C beta 1 expression in the dorsolateral prefrontal cortex from patients with schizophrenia at different stages of illness

M Udawela, E Scarr, AJ Hannan, EA Thomas, B Dean

2011-02-01

Objective: Our recent microarray study detected decreases in the expression of phospholipase C beta 1 mRNA in the dorsolateral pre..

Changes in Gene Expression in Subjects with Schizophrenia Associated with Disease Progression

Brian Dean, Andrew Gibbons, Elizabeth Scarr, Elizabeth A Thomas

2011-01-01

Schizophrenia is increasingly recognised as a progressive disorder because the central nervous system (CNS) structure, symptom pro..

Decreased Neuregulin 1 C-terminal fragment in Brodmann's area 6 of patients with schizophrenia

A Barakat, B Dean, E Scarr, G Evin

2010-12-01

Neuregulin 1 (NRG1) is a susceptibility gene for schizophrenia. A decrease in NRG1-ErbB4 signalling has also been associated with ..

Low density lipoprotein receptor-related protein and apolipoprotein E expression is altered in schizophrenia

AS Gibbons, EA Thomas, E Scarr, B Dean

2010-12-01

Our recent microarray study reported altered mRNA expression of several low density lipoprotein receptor-related proteins (LRP) as..

Effects of benzodiazepine treatment on cortical GABAA and muscarinic receptors: Studies in schizophrenia and rats

MC McLeod, E Scarr, B Dean

2010-09-01

Changes in cortical γ-aminobutyric acid A (GABA<inf>A</inf>) receptors and muscarinic receptors have been reported in schizophreni..

Coexpression network analysis of neural tissue reveals perturbations in developmental processes in schizophrenia

A Torkamani, B Dean, NJ Schork, EA Thomas

2010-04-01

We performed integrated gene coexpression network analysis on two large microarray-based brain gene expression data sets generated..

Regionally-specific changes in levels of tumour necrosis factor in the dorsolateral prefrontal cortex obtained postmortem from subjects with major depressive disorder

B Dean, N Tawadros, E Scarr, AS Gibbons

2010-01-01

Background: From studies in the periphery, changed levels of tumour necrosis factor (TNF) have been implicated in the pathophysiol..

Levels of neuregulin 1 and 3 proteins in Brodmann's area 46 from subjects with schizophrenia and bipolar disorder

S Boer, M Berk, B Dean

2009-11-27

Neuregulin (NRG) 1Iα and NRG3 proteins levels were measured in Brodmann's area 46 from 20 subjects with schizophrenia, 8 subjects ..

Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia

E Scarr, TF Cowie, S Kanellakis, S Sundram, C Pantelis, B Dean

2009-11-01

Schizophrenia is widely acknowledged as being a syndrome, consisting of an undefined number of diseases probably with differing pa..

Evolution of the human CNS cholineric system: Has this resulted in the emergence of psychiatric disease?

B Dean

2009-11-01

The aim of the present study was to review the available literature on the evolutionary processes that have led to the develzopmen..

Altered M1 Muscarinic Acetylcholine Receptor (CHRM1)-Gαq/11 Coupling in a Schizophrenia Endophenotype

H Salah-Uddin, E Scarr, G Pavey, K Harris, JJ Hagan, B Dean, RAJ Challiss, JM Watson

2009-08-01

Alterations in muscarinic acetylcholine receptor (CHRM) populations have been implicated in the pathology of schizophrenia. Here w..

Decreased muscarinic receptor binding in the frontal cortex of bipolar disorder and major depressive disorder subjects

AS Gibbons, E Scarr, C McLean, S Sundram, B Dean

2009-08-01

Background: Dysfunction of the cholinergic muscarinic receptors has been implicated in the pathology of bipolar disorder and major..

Regional and duration of illness differences in the alteration of NCAM-180 mRNA expression within the cortex of subjects with schizophrenia

AS Gibbons, EA Thomas, B Dean

2009-07-01

Schizophrenia has been proposed to have a neurodevelopmental aetiology. Neural Cell Adhesion Molecule 1 (NCAM1) is involved in sev..

Evidence for disruption of sphingolipid metabolism in schizophrenia

S Narayan, SR Head, TJ Gilmartin, B Dean, EA Thomas

2009-03-31

As the field of glycobiology grows, important roles for glycolipids and glycoproteins in neurological disorders are being increasi..

Role of the cholinergic system in the pathology and treatment of schizophrenia

E Scarr, B Dean

2009-01-01

Schizophrenia is a devastating psychiatric disorder; the diagnosis probably encompasses a number of illnesses with similar clinica..

Muscarinic receptors: Do they have a role in the pathology and treatment of schizophrenia?

E Scarr, B Dean

2008-12-01

The high affinity of antipsychotic drugs for the dopamine D2 receptor focused attention onto the role of these receptors in the ge..

Using differential solubilization and 2-D gel electrophoresis to visualize increased numbers of proteins in the human cortex and caudate nucleus and putamen

B Dean, G Pavey, AI Smith

2008-09-01

The aim of this study was to determine if differential solubilization of human CNS proteins would increase the total number of pro..

Regulator of G-protein signalling 4 expression is not altered in the prefrontal cortex in schizophrenia

A Stuart Gibbons, E Scarr, CE McOmish, AJ Hannan, E Thomas, B Dean

2008-08-01

Objectives: Regulator of G-protein signalling 4 (RGS4) modulates signal transduction through several neurotransmitter receptor sys..

Plasma apolipoprotein E is decreased in schizophrenia spectrum and bipolar disorder

B Dean, A Digney, S Sundram, E Thomas, E Scarr

2008-02-28

We have shown that plasma apolipoprotein E is significantly decreased in treatment-free subjects with schizophrenia spectrum and b..

Treatment with haloperidol and diazepam alters GABAA receptor density in the rat brain

MC McLeod, S Sundram, B Dean

2008-02-15

A significant body of data suggests that GABA<inf>A</inf> receptors are altered in the CNS of subjects with schizophrenia. However..

Increased levels of serotonin2A receptors and serotonin transporter in the CNS of neuregulin 1 hypomorphic/mutant mice

B Dean, T Karl, G Pavey, S Boer, L Duffy, E Scarr

2008-02-01

Changes in neuregulin 1 expression have been reported in the CNS from subjects with schizophrenia. As neuregulin 1 is important in..

CNS 14-3-3ζ: Changes with sex but not psychiatric diagnoses or psychotropic drug treatment

B Dean, SA Boer, A Mackinnon, M Berk

2007-07-01

mRNA for 14-3-3ζ, an abundant signalling protein in human CNS, is reported as decreased or unchanged in cortex from subjects with ..

Altered Hippocampal Muscarinic M4, but Not M1, Receptor Expression from Subjects with Schizophrenia

E Scarr, S Sundram, D Keriakous, B Dean

2007-05-15

Background: Having shown a decrease in [³H]pirenzepine binding in the hippocampus from subjects with schizophrenia, we ..

Gene expression profiling in Brodmann's area 46 from subjetcs with schizophrenia

B Dean, D Keriakous, E Scarr, EA Thomas

2007-04-01

Objective: To identify altered gene expression in the dorsolateral prefrontal cortex obtained after death from subjects with schiz..

Cortical serotonin7, 1D and 1F receptors: Effects of schizophrenia, suicide and antipsychotic drug treatment

B Dean, G Pavey, D Thomas, E Scarr

2006-12-01

Abnormalities in serotonergic function are thought to be important in the pathology of schizophrenia. Postmortem CNS studies sugge..