Grant number: 400231
Related publications (27)
Peritoneal Tumorigenesis and Inflammation are Ameliorated by Humidified-Warm Carbon Dioxide Insufflation in the Mouse
Sandra Carpinteri, Shienny Sampurno, Maria-Pia Bernardi, Markus Germann, Jordane Malaterre, Alexander Heriot, Brenton A Chambers, Steven E Mutsaers, Andrew C Lynch, Robert G Ramsay
BACKGROUND: Conventional laparoscopic surgery uses CO2 that is dry and cold, which can damage peritoneal surfaces. It is speculate..
Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis
Dane Cheasley, Lloyd Pereira, Shienny Sampurno, Oliver Sieber, Robert Jorissen, Huiling Xu, Markus Germann, Yuqian Yan, Robert G Ramsay, Jordane Malaterre
UNLABELLED: Cyclin E1 is essential for the reentry of quiescent cells into the cell cycle. When hypomorphic mutant Myb mice (Myb(P..
Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5( ) Stem Cells
Dustin J Flanagan, Toby J Phesse, Nick Barker, Renate HM Schwab, Nancy Amin, Jordane Malaterre, Daniel E Stange, Cameron J Nowell, Scott A Currie, Jarel TS Saw, Eva Beuchert, Robert G Ramsay, Owen J Sansom, Matthias Ernst, Hans Clevers, Elizabeth Vincan
The mammalian adult small intestinal epithelium is a rapidly self-renewing tissue that is maintained by a pool of cycling stem cel..
MYB Elongation Is Regulated by the Nucleic Acid Binding of NF kappa B p50 to the Intronic Stem-Loop Region
Lloyd A Pereira, Honor J Hugo, Jordane Malaterre, Huiling Xu, Secondo Sonza, Alina Cures, Damian FJ Purcell, Paul A Ramsland, Steven Gerondakis, Thomas J Gonda, Robert G Ramsay
MYB transcriptional elongation is regulated by an attenuator sequence within intron 1 that has been proposed to encode a RNA stem ..
Myb via TGF beta is required for collagen type 1 production and skin integrity
Shienny Sampurno, Ryan Cross, Helen Pearson, Pritinder Kaur, Jordane Malaterre, Robert G Ramsay
Skin integrity requires an ongoing replacement and repair orchestrated by several cell types. We previously investigated the archi..
Therapeutic DNA vaccination against colorectal cancer by targeting the MYB oncoprotein
Ryan S Cross, Jordane Malaterre, Alexander J Davenport, Sandra Carpinteri, Robin L Anderson, Phillip K Darcy, Robert G Ramsay
Cancers can be addicted to continued and relatively high expression of nuclear oncoproteins. This is evident in colorectal cancer ..
Cohesin Rad21 Mediates Loss of Heterozygosity and Is Upregulated via Wnt Promoting Transcriptional Dysregulation in Gastrointestinal Tumors
Huiling Xu, Yuqian Yan, Siddhartha Deb, Danny Rangasamy, Markus Germann, Jordane Malaterre, Noreen C Eder, Robyn L Ward, Nicholas J Hawkins, Richard W Tothill, Long Chen, Neil J Mortensen, Stephen B Fox, Michael J McKay, Robert G Ramsay
Loss of heterozygosity (LOH) of the adenomatous polyposis coli (APC) gene triggers a series of molecular events leading to intesti..
Tripartite interactions between Wnt signaling, Notch and Myb for stem/progenitor cell functions during intestinal tumorigenesis
Markus Germann, Huiling Xu, Jordane Malaterre, Shienny Sampurno, Mathilde Huyghe, Dane Cheasley, Silvia Fre, Robert G Ramsay
Deletion studies confirm Wnt, Notch and Myb transcriptional pathway engagement in intestinal tumorigenesis. Nevertheless, their co..
Marker genes identify three somatic cell types in the fetal mouse ovary
Raphael H Rastetter, Pascal Bernard, James S Palmer, Anne-Amandine Chassot, Huijun Chen, Patrick S Western, Robert G Ramsay, Marie-Christine Chaboissier, Dagmar Wilhelm
The two main functions of the ovary are the production of oocytes, which allows the continuation of the species, and secretion of ..
Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-beta-catenin-mediated intestinal tumor growth and regeneration
Toby J Phesse, Michael Buchert, Emma Stuart, Dustin J Flanagan, Maree Faux, Shoukat Afshar-Sterle, Francesca Walker, Hui-Hua Zhang, Cameron J Nowell, Robert Jorissen, Chin Wee Tan, Yumiko Hirokawa, Moritz F Eissmann, Ashleigh R Poh, Jordane Malaterre, Helen B Pearson, David G Kirsch, Paolo Provero, Valeria Poli, Robert G Ramsay
Most colon cancers arise from somatic mutations in the tumor suppressor gene APC (adenomatous polyposis coli), and these mutations..
Selective CREB-dependent cyclin expression mediated by the PI3K and MAPK pathways supports glioma cell proliferation
P Daniel, G Filiz, DV Brown, F Hollande, M Gonzales, G D'Abaco, N Papalexis, WA Phillips, J Malaterre, RG Ramsay, T Mantamadiotis
The cyclic-AMP response element binding (CREB) protein has been shown to have a pivotal role in cell survival and cell proliferati..
RAD21 cohesin overexpression is a prognostic and predictive marker exacerbating poor prognosis in KRAS mutant colorectal carcinomas
S Deb, H Xu, J Tuynman, J George, Y Yan, J Li, RL Ward, N Mortensen, NJ Hawkins, MJ McKay, RG Ramsay, SB Fox
BACKGROUND: RAD21 is a component of the cohesion complex and is integral to chromosome segregation and error-free DNA repair. RAD2..
Physiological expression of the PI3K-activating mutation Pik3ca(H1047R) combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice
Lauren M Hare, Toby J Phesse, Paul M Waring, Karen G Montgomery, Kathryn M Kinross, Kevin Mills, Vincent Roh, Joan K Heath, Robert G Ramsay, Matthias Ernst, Wayne A Phillips
PIK3CA, the gene encoding the p110α catalytic subunit of PI3K (phosphoinositide 3-kinase), is mutated in approximately 20% of spor..
The Myb-p300-CREB axis modulates intestine homeostasis, radiosensitivity and tumorigenesis
S Sampurno, A Bijenhof, D Cheasley, H Xu, S Robine, D Hilton, WS Alexander, L Pereira, T Mantamadiotis, J Malaterre, RG Ramsay
The gastrointestinal (GI) epithelium is constantly renewing, depending upon the intestinal stem cells (ISC) regulated by a spectru..
The CSF-1 receptor fashions the intestinal stem cell niche
Dilara Akcora, Duy Huynh, Sally Lightowler, Markus Germann, Sylvie Robine, Jan R de May, Jeffrey W Pollard, E Richard Stanley, Jordane Malaterre, Robert G Ramsay
Gastrointestinal (GI) homeostasis requires the action of multiple pathways. There is some controversy regarding whether small inte..
CSF-1 Receptor-Dependent Colon Development, Homeostasis and Inflammatory Stress Response
Huynh Duy, Dilara Akcora, Jordane Malaterre, Chee Kai Chan, Xu-Ming Dai, Ivan Bertoncello, E Richard Stanley, Robert G Ramsay
The colony stimulating factor-1 (CSF-1) receptor (CSF-1R) directly regulates the development of Paneth cells (PC) and influences p..
Delayed development of specific thyroid hormone-regulated events in transthyretin null mice
Julie A Monk, Natalie A Sims, Katarzyna M Dziegielewska, Roy E Weiss, Robert G Ramsay, Samantha J Richardson
Thyroid hormones (THs) are vital for normal postnatal development. Extracellular TH distributor proteins create an intravascular r..
Direct repression of MYB by ZEB1 suppresses proliferation and epithelial gene expression during epithelial-to-mesenchymal transition of breast cancer cells
Honor J Hugo, Lloyd Pereira, Randy Suryadinata, Yvette Drabsch, Thomas J Gonda, NPA Devika Gunasinghe, Cletus Pinto, Eliza TL Soo, Bryce JW van denderen, Prue Hill, Robert G Ramsay, Boris Sarcevic, Donald F Newgreen, Erik W Thompson
INTRODUCTION: Epithelial-to-mesenchymal transition (EMT) promotes cell migration and is important in metastasis. Cellular prolifer..
Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules
Andre J Faure, Dominic Schmidt, Stephen Watt, Petra C Schwalie, Michael D Wilson, Huiling Xu, Robert G Ramsay, Duncan T Odom, Paul Flicek
The cohesin protein complex contributes to transcriptional regulation in a CTCF-independent manner by colocalizing with master reg..
The tumor suppressor Apc controls planar cell polarities central to gut homeostasis
Julien Bellis, Isabelle Duluc, Beatrice Romagnolo, Christine Perret, Maree C Faux, Denis Dujardin, Caroline Formstone, Sally Lightowler, Robert G Ramsay, Jean-Noel Freund, Jan R De Mey
The stem cells (SCs) at the bottom of intestinal crypts tightly contact niche-supporting cells and fuel the extraordinary tissue r..
Estrogen receptor-alpha recruits P-TEFb to overcome transcriptional pausing in intron 1 of the MYB gene
Partha Mitra, Lloyd A Pereira, Yvette Drabsch, Robert G Ramsay, Thomas J Gonda
The MYB proto-oncogene is expressed in most estrogen receptor-positive (ERα(+)) breast tumors and cell lines. Expression of MYB is..
RAD21 Mutations Cause a Human Cohesinopathy
Matthew A Deardorff, Jonathan J Wilde, Melanie Albrecht, Emma Dickinson, Stephanie Tennstedt, Diana Braunholz, Maren Moennich, Yuqian Yan, Weizhen Xu, Maria Concepcion Gil-Rodriguez, Dinah Clark, Hakon Hakonarson, Sara Halbach, Laura Daniela Michelis, Abhinav Rampuria, Eva Rossier, Stephanie Spranger, Lionel Van Maldergem, Sally Ann Lynch, Gabriele Gillessen-Kaesbach
The evolutionarily conserved cohesin complex was originally described for its role in regulating sister-chromatid cohesion during ..
Enhanced Lithium-Induced Brain Recovery Following Cranial Irradiation Is Not Impeded by Inflammation
Jordane Malaterre, Cameron S McPherson, Delphine Denoyer, Emily Lai, Jim Hagekyriakou, Sally Lightowler, Koishi Shudo, Matthias Ernst, David M Ashley, Jennifer L Short, Greg Wheeler, Robert G Ramsay
Radiation-induced brain injury occurs in many patients receiving cranial radiation therapy, and these deleterious effects are most..
Colony-Stimulating Factor-1 Promotes Kidney Growth and Repair via Alteration of Macrophage Responses
Maliha A Alikhan, Christina V Jones, Timothy M Williams, Anthony G Beckhouse, Anne L Fletcher, Michelle M Kett, Samy Sakkal, Chrishan S Samuel, Robert G Ramsay, James A Deane, Christine A Wells, Melissa H Little, David A Hume, Sharon D Ricardo
Colony-stimulating factor (CSF)-1 controls the survival, proliferation, and differentiation of macrophages, which are recognized a..
PHLDA1 Expression Marks the Putative Epithelial Stem Cells and Contributes to Intestinal Tumorigenesis
Anuratha Sakthianandeswaren, Michael Christie, Carla D'Andreti, Cary Tsui, Robert N Jorissen, Shan Li, Nicholas I Fleming, Peter Gibbs, Lara Lipton, Jordane Malaterre, Robert G Ramsay, Toby J Phesse, Matthias Ernst, Rosemary E Jeffery, Richard Poulsom, Simon J Leedham, Stefania Segditsas, Ian PM Tomlinson, Oliver K Bernhard, Richard J Simpson
Studies employing mouse models have identified crypt base and position +4 cells as strong candidates for intestinal epithelial ste..