Epidemiology of Chronic Disease, Health Interventions and DNA Studies

Genetic data from nearly 63,000 women of European descent predicts DNA methylation biomarkers and epithelial ovarian cancer risk

Y Yang, L Wu, X Shu, Y Lu, XO Shu, Q Cai, A Beeghly-Fadiel, B Li, F Ye, A Berchuck, H Anton-Culver, S Banerjee, J Benitez, L Bjørge, JD Brenton, R Butzow, IG Campbell, J Chang-Claude, K Chen, LS Cook

2019-02-01

DNA methylation is instrumental for gene regulation. Global changes in the epigenetic landscape have been recognized as a hallmark..

A transcriptome-wide association study among 97,898 women to identify candidate susceptibility genes for epithelial ovarian cancer risk

Y Lu, A Beeghly-Fadiel, L Wu, X Guo, B Li, JM Schildkraut, HK Im, YA Chen, JB Permuth, BM Reid, JK Teer, KB Moysich, IL Andrulis, H Anton-Culver, BK Arun, EV Bandera, RB Barkardottir, DR Barnes, J Benitez, L Bjorge

2018-09-15

Large-scale genome-wide association studies (GWAS) have identified approximately 35 loci associated with epithelial ovarian cancer..

Body mass index and breast cancer survival: A Mendelian randomization analysis

Q Guo, S Burgess, C Turman, MK Bolla, Q Wang, M Lush, J Abraham, K Aittomäki, IL Andrulis, C Apicella, V Arndt, M Barrdahl, J Benitez, CD Berg, C Blomqvist, SE Bojesen, B Bonanni, JS Brand, H Brenner, A Broeks

2017-12-01

Background: There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with br..

Association analysis identifies 65 new breast cancer risk loci

K Michailidou, S Lindström, J Dennis, J Beesley, S Hui, S Kar, A Lemaçon, P Soucy, D Glubb, A Rostamianfar, MK Bolla, Q Wang, J Tyrer, E Dicks, A Lee, Z Wang, J Allen, R Keeman, U Eilber, JD French

2017-11-02

Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-codin..

Use of a novel nonparametric version of DEPTH to identify genomic regions associated with prostate cancer risk

RJ MacInnis, DF Schmidt, E Makalic, G Severi, LM FitzGerald, M Reumann, MK Kapuscinski, A Kowalczyk, Z Zhou, B Goudey, G Qian, QM Bui, DJ Park, A Freeman, MC Southey, AAA Olama, Z Kote-Jarai, RA Eeles, JL Hopper, GG Giles

2016-12-01

Background: We have developed a genome-wide association study analysis method called DEPTH (DEPendency of association on the numbe..

Dietary protein intake and risk of type 2 diabetes: Results from the Melbourne Collaborative Cohort Study and a meta-analysis of prospective studies

X Shang, D Scott, AM Hodge, DR English, GG Giles, PR Ebeling, KM Sanders

2016-11-01

Background: Reported associations between protein intake from different sources and type 2 diabetes (T2D) have been inconsistent. ..

Past physical activity and age-related macular degeneration: The Melbourne Collaborative Cohort Study

MB McGuinness, A Karahalios, JA Simpson, RH Guymer, LD Robman, AM Hodge, E Cerin, GG Giles, RP Finger

2016-10-01

Background/aims: To assess the association between past physical activity and early, intermediate and late age-related macular deg..

Mammographic density and risk of breast cancer by mode of detection and tumor size: A case-control study

K Krishnan, L Baglietto, C Apicella, J Stone, MC Southey, DR English, GG Giles, JL Hopper

2016-06-18

Background: Risk of screen-detected breast cancer mostly reflects inherent risk, while risk of interval cancer reflects inherent r..

Reticular pseudodrusen and their association with age-related macular degeneration the melbourne collaborative cohort study

RP Finger, E Chong, MB McGuinness, LD Robman, KZ Aung, G Giles, PN Baird, RH Guymer

2016-03-01

Purpose To determine the prevalence of reticular pseudodrusen (RPD) and its association with age-related macular degeneration (AMD..

No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: Implications for gene panel testing

DF Easton, F Lesueur, B Decker, K Michailidou, J Li, J Allen, C Luccarini, KA Pooley, M Shah, MK Bolla, Q Wang, J Dennis, J Ahmad, ER Thompson, F Damiola, M Pertesi, C Voegele, N Mebirouk, N Robinot, G Durand

2016-02-26

Background BRCA1 interacting protein C-terminal helicase 1 (BRIP1) is one of the Fanconi Anaemia Complementation (FANC) group fami..

Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21

Y Hamdi, P Soucy, V Adoue, K Michailidou, S Canisius, A Lemaçon, A Droit, IL Andrulis, H Anton-Culver, V Arndt, C Baynes, C Blomqvist, NV Bogdanova, SE Bojesen, MK Bolla, B Bonanni, AL Borresen-Dale, JS Brand, H Brauch, H Brenner

2016-01-01

There are significant inter-individual differences in the levels of gene expression. Through modulation of gene expression, cis-ac..

Global measures of peripheral blood-derived DNA methylation as a risk factor in the development of mature B-cell neoplasms

N Wong Doo, E Makalic, JE Joo, CM Vajdic, DF Schmidt, EM Wong, CH Jung, G Severi, DJ Park, J Chung, L Baglietto, HM Prince, JF Seymour, C Tam, JL Hopper, DR English, RL Milne, SJ Harrison, MC Southey, GG Giles

2016-01-01

Aim: To examine whether peripheral blood methylation is associated with risk of developing mature B-cell neoplasms (MBCNs). Materi..

Inherited variants affecting RNA editing may contribute to ovarian cancer susceptibility: Results from a large-scale collaboration

JB Permuth, B Reid, M Earp, YA Chen, ANA Monteiro, Z Chen, G Chenevix-Trench, PA Fasching, MW Beckmann, D Lambrechts, A Vanderstichele, E Van Niewenhuyse, I Vergote, MA Rossing, JA Doherty, J Chang-Claude, K Moysich, K Odunsi, MT Goodman, YB Shvetsov

2016-01-01

RNA editing in mammals is a form of post-transcriptional modification in which adenosine is converted to inosine by the adenosine ..

Alcohol consumption for different periods in life, intake pattern over time and all-cause mortality

H Jayasekara, RJ MacInnis, AM Hodge, JL Hopper, GG Giles, R Room, DR English

2015-12-01

© The Author 2014. Published by Oxford University Press on behalf of Faculty of Public Health. All rights reserved. For permission..

Fine-scale mapping of the 4q24 locus identifies & pr two Independent loci associated with breast cancer risk

X Guo, J Long, C Zeng, K Michailidou, M Ghoussaini, MK Bolla, Q Wang, RL Milne, XO Shu, Q Cai, J Beesley, SP Kar, IL Andrulis, H Anton-Culver, V Arndt, MW Beckmann, A Beeghly-Fadiel, J Benitez, W Blot, N Bogdanova

2015-11-01

Background: A recent association study identified a common variant (rs9790517) at 4q24 to be associated with breast cancer risk. I..

Age related macular degeneration and total hip replacement due to osteoarthritis or fracture: Melbourne Collaborative Cohort Study

EW Chong, Y Wang, LD Robman, KZ Aung, GA Makeyeva, GG Giles, S Graves, FM Cicuttini, RH Guymer

2015-09-10

Osteoarthritis is the leading cause of total hip replacement, accounting for more than 80% of all total hip replacements. Emerging..

A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density

A Rudolph, PA Fasching, S Behrens, U Eilber, MK Bolla, Q Wang, D Thompson, K Czene, JS Brand, J Li, C Scott, VS Pankratz, K Brandt, E Hallberg, JE Olson, A Lee, MW Beckmann, AB Ekici, L Haeberle, G Maskarinec

2015-08-16

Introduction: Mammographic density is an established breast cancer risk factor with a strong genetic component and can be increase..

Age-related macular degeneration phenotypes associated with mutually exclusive homozygous risk variants in CFH and htra1 genes

EW Chong, FM Amirul Islam, LD Robman, KZ Aung, AJ Richardson, PN Baird, RH Guymer

2015-05-08

Purpose: To determine age-related macular degeneration (AMD) phenotypes associated with mutually exclusive homozygotic risk varian..

Age-related macular degeneration in ethnically diverse Australia: Melbourne collaborative cohort study

LD Robman, FMA Islam, EWT Chong, MKM Adams, JA Simpson, KZ Aung, GA Makeyeva, JL Hopper, DR English, GG Giles, PN Baird, RH Guymer

2015-04-01

Purpose: To determine and compare the prevalence of age-related macular degeneration (AMD) in older Australians of Anglo-Celtic an..

Natural history of HFE simple heterozygosity for C282Y and H63D: A prospective 12-year study

SG Zaloumis, KJ Allen, NA Bertalli, L Turkovic, MB Delatycki, AJ Nicoll, CE Mclaren, DR English, JL Hopper, GG Giles, GJ Anderson, JK Olynyk, LW Powell, LC Gurrin, M Bahlo, CD Vulpe, SM Forrest, AR Fletcher

2015-04-01

Background and Aim: The risk of hemochromatosis-related morbidity for HFE simple heterozygosity for either the C282Y or H63D subst..

Development and validation of a risk score predicting risk of colorectal cancer

A Steffen, RJ MacInnis, G Joshy, GG Giles, E Banks, D Roder

2014-11-01

Background: Quantifying the risk of colorectal cancer for individuals is likely to be useful for health service provision. Our aim..

Association between obesity and magnetic resonance imaging defined patellar tendinopathy in community-based adults: A cross-sectional study

J Fairley, J Toppi, FM Cicuttini, AE Wluka, GG Giles, J Cook, R O'Sullivan, Y Wang

2014-08-07

Background: Patellar tendinopathy is a common cause of activity-related anterior knee pain. Evidence is conflicting as to whether ..

Change in body size and mortality: Results from the Melbourne Collaborative cohort study

A Karahalios, JA Simpson, L Baglietto, RJ MacInnis, AM Hodge, GG Giles, DR English

2014-07-02

Background: The association between change in weight or body mass index, and mortality is widely reported, however, both measures ..

Risk of ovarian cancer and the NF-kB pathway: Genetic association with IL1A and TNFSF10

B Charbonneau, MS Block, WR Bamlet, RA Vierkant, KR Kalli, Z Fogarty, DN Rider, TA Sellers, SS Tworoger, E Poole, HA Risch, HB Salvesen, LA Kiemeney, L Baglietto, GG Giles, G Severi, B Trabert, N Wentzensen, G Chenevix-Trench, AS Whittemore

2014-02-01

A missense single-nucleotide polymorphism (SNP) in the immune modulatory gene IL1A has been associated with ovarian cancer risk (r..

Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: A case-control study

N Johnson, F Dudbridge, N Orr, L Gibson, ME Jones, MJ Schoemaker, EJ Folkerd, BP Haynes, JL Hopper, MC Southey, GS Dite, C Apicella, MK Schmidt, A Broeks, LJ Van't Veer, F Atsma, K Muir, A Lophatananon, PA Fasching, MW Beckmann

2014-01-01

Introduction: We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22..

Dietary intake of B vitamins and methionine and breast cancer risk

JK Bassett, L Baglietto, AM Hodge, G Severi, JL Hopper, DR English, GG Giles

2013-08-01

Purpose: We investigated prospectively the relationship between dietary intakes of methionine and B vitamins associated with one-c..

The prevalence and risk factors of epiretinal membranes: The Melbourne collaborative cohort study

KZ Aung, G Makeyeva, MK Adams, EWT Chong, L Busija, GG Giles, DR English, J Hopper, PN Baird, RH Guymer, LD Robman

2013-05-01

PURPOSE: To determine the prevalence of epiretinal membranes (ERMs) in Melbourne, Australia and its risk factors in this populatio..

Confirmation of the reduction of hormone replacement therapy-related breast cancer risk for carriers of the HSD17B1-937-G variant

O Obazee, C Justenhoven, S Winter, J Chang-Claude, A Rudolph, P Seibold, D Flesch-Janys, U Hannelius, J Li, K Humphreys, P Hall, G Giles, G Severi, L Baglietto, M Southey, S Rabstein, V Harth, A Lotz, B Pesch, T Brüning

2013-04-01

17β-hydroxysteroid dehydrogenase type 1 (HSD17B1) plays an important role in the biosynthesis of 17β-estradiol. The current study ..

Effect of long-term vigorous physical activity on healthy adult knee cartilage

AJ Teichtahl, AE Wluka, Y Wang, A Forbes, ML Davies-Tuck, DR English, GG Giles, FM Cicuttini

2012-06-01

Introduction: Whether participation in long-term vigorous physical activity affects knee cartilage is unclear and may depend on th..

A flatter proximal trochlear groove is associated with patella cartilage loss

AJ Teichtahl, F Hanna, AE Wluka, DM Urquhart, Y Wang, DR English, GG Giles, FM Cicuttini

2012-03-01

PURPOSE: The bony articular surface contributes to a joint's congruency, and it might be a determinant of structural change. The a..

Second to fourth digit ratio (2D:4D) and concentrations of circulating sex hormones in adulthood

DC Muller, GG Giles, J Bassett, HA Morris, JT Manning, JL Hopper, DR English, G Severi

2011-04-27

Background: The second to fourth digit ratio (2D:4D) is used as a marker of prenatal sex hormone exposure. The objective of this s..

Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: A combined case-control study

RL Milne, MM Gaudet, AB Spurdle, PA Fasching, FJ Couch, J Benítez, JI Arias Pérez, MP Zamora, N Malats, I dos Santos Silva, LJ Gibson, O Fletcher, N Johnson, H Anton-Culver, A Ziogas, J Figueroa, L Brinton, ME Sherman, J Lissowska, JL Hopper

2010-12-31

Introduction: Several common breast cancer genetic susceptibility variants have recently been identified. We aimed to determine ho..