Epidemiology of chronic disease, health interventions and DNA studies

Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk

Yaohua Yang, Lang Wu, Xiang Shu, Yingchang Lu, Xiao-Ou Shu, Qiuyin Cai, Alicia Beeghly-Fadiel, Bingshan Li, Fei Ye, Andrew Berchuck, Hoda Anton-Culver, Susana Banerjee, Javier Benitez, Line Bjorge, James D Brenton, Ralf Butzow, Ian G Campbell, Jenny Chang-Claude, Kexin Chen, Linda S Cook

2019-02-01

DNA methylation is instrumental for gene regulation. Global changes in the epigenetic landscape have been recognized as a hallmark..

A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk

Yingchang Lu, Alicia Beeghly-Fadiel, Lang Wu, Xingyi Guo, Bingshan Li, Joellen M Schildkraut, Hae Kyung Im, Yian A Chen, Jennifer B Permuth, Brett M Reid, Jamie K Teer, Kirsten B Moysich, Irene L Andrulis, Hoda Anton-Culver, Banu K Arun, Elisa V Bandera, Rosa B Barkardottir, Daniel R Barnes, Javier Benitez, Line Bjorge

2018-09-15

Large-scale genome-wide association studies (GWAS) have identified approximately 35 loci associated with epithelial ovarian cancer..

Body mass index and breast cancer survival: a Mendelian randomization analysis

Qi Guo, Stephen Burgess, Constance Turman, Manjeet K Bolla, Qin Wang, Michael Lush, Jean Abraham, Kristiina Aittomaki, Irene L Andrulis, Carmel Apicella, Volker Arndt, Myrto Barrdahl, Javier Benitez, Christine D Berg, Carl Blomqvist, Stig E Bojesen, Bernardo Bonanni, Judith S Brand, Hermann Brenner, Annegien Broeks

2017-12-01

Background: There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with br..

Association analysis identifies 65 new breast cancer risk loci

Kyriaki Michailidou, Sara Lindstrom, Joe Dennis, Jonathan Beesley, Shirley Hui, Siddhartha Kar, Audrey Lemacon, Penny Soucy, Dylan Glubb, Asha Rostamianfar, Manjeet K Bolla, Qin Wang, Jonathan Tyrer, Ed Dicks, Andrew Lee, Zhaoming Wang, Jamie Allen, Renske Keeman, Ursula Eilber, Juliet D French

2017-11-02

Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-codin..

Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21

Yosr Hamdi, Penny Soucy, Veronique Adoue, Kyriaki Michailidou, Sander Canisius, Audrey Lemacon, Arnaud Droit, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Caroline Baynes, Carl Blomqvist, Natalia V Bogdanova, Stig E Bojesen, Manjeet K Bolla, Bernardo Bonanni, Anne-Lise Borresen-Dale, Judith S Brand, Hiltrud Brauch, Hermann Brenner

2016-12-06

There are significant inter-individual differences in the levels of gene expression. Through modulation of gene expression, cis-ac..

Use of a Novel Nonparametric Version of DEPTH to Identify Genomic Regions Associated with Prostate Cancer Risk

Robert J MacInnis, Daniel F Schmidt, Enes Makalic, Gianluca Severi, Liesel M FitzGerald, Matthias Reumann, Miroslaw K Kapuscinski, Adam Kowalczyk, Zeyu Zhou, Benjamin Goudey, Guoqi Qian, Quang M Bui, Daniel J Park, Adam Freeman, Melissa C Southey, Ali Amin Al Olama, Zsofia Kote-Jarai, Rosalind A Eeles, John L Hopper, Graham G Giles

2016-12-01

BACKGROUND: We have developed a genome-wide association study analysis method called DEPTH (DEPendency of association on the numbe..

Inherited variants affecting RNA editing may contribute to ovarian cancer susceptibility: results from a large-scale collaboration

Jennifer B Permuth, Brett Reid, Madalene Earp, Y Ann Chen, Alvaro NA Monteiro, Zhihua Chen, Georgia Chenevix-Trench, Peter A Fasching, Matthias W Beckmann, Diether Lambrechts, Adriaan Vanderstichele, Els Van Niewenhuyse, Ignace Vergote, Mary Anne Rossing, Jennifer Anne Doherty, Jenny Chang-Claude, Kirsten Moysich, Kunle Odunsi, Marc T Goodman, Yurii B Shvetsov

2016-11-08

RNA editing in mammals is a form of post-transcriptional modification in which adenosine is converted to inosine by the adenosine ..

Dietary protein intake and risk of type 2 diabetes: results from the Melbourne Collaborative Cohort Study and a meta-analysis of prospective studies

Xianwen Shang, David Scott, Allison M Hodge, Dallas R English, Graham G Giles, Peter R Ebeling, Kerrie M Sanders

2016-11-01

BACKGROUND: Reported associations between protein intake from different sources and type 2 diabetes (T2D) have been inconsistent. ..

Past physical activity and age-related macular degeneration: the Melbourne Collaborative Cohort Study

Myra B McGuinness, Amalia Karahalios, Julie A Simpson, Robyn H Guymer, Luba D Robman, Allison M Hodge, Ester Cerin, Graham G Giles, Robert P Finger

2016-10-01

BACKGROUND/AIMS: To assess the association between past physical activity and early, intermediate and late age-related macular deg..

Mammographic density and risk of breast cancer by mode of detection and tumor size: a case-control study

Kavitha Krishnan, Laura Baglietto, Carmel Apicella, Jennifer Stone, Melissa C Southey, Dallas R English, Graham G Giles, John L Hopper

2016-06-18

BACKGROUND: Risk of screen-detected breast cancer mostly reflects inherent risk, while risk of interval cancer reflects inherent r..

No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing

Douglas F Easton, Fabienne Lesueur, Brennan Decker, Kyriaki Michailidou, Jun Li, Jamie Allen, Craig Luccarini, Karen A Pooley, Mitul Shah, Manjeet K Bolla, Qin Wang, Joe Dennis, Jamil Ahmad, Ella R Thompson, Francesca Damiola, Maroulio Pertesi, Catherine Voegele, Noura Mebirouk, Nivonirina Robinot, Geoffroy Durand

2016-05-01

BACKGROUND: BRCA1 interacting protein C-terminal helicase 1 (BRIP1) is one of the Fanconi Anaemia Complementation (FANC) group fam..

Reticular Pseudodrusen and Their Association with Age-Related Macular Degeneration

Robert P Finger, Elaine Chong, Myra B McGuinness, Luba D Robman, Khin Zaw Aung, Graham Giles, Paul N Baird, Robyn H Guymer

2016-03-01

PURPOSE: To determine the prevalence of reticular pseudodrusen (RPD) and its association with age-related macular degeneration (AM..

Global measures of peripheral blood-derived DNA methylation as a risk factor in the development of mature B-cell neoplasms

Nicole Wong Doo, Enes Makalic, JiHoon E Joo, Claire M Vajdic, Daniel F Schmidt, Ee Ming Wong, Chol-Hee Jung, Gianluca Severi, Daniel J Park, Jessica Chung, Laura Baglietto, Henry Miles Prince, John F Seymour, Constantine Tam, John L Hopper, Dallas R English, Roger L Milne, Simon J Harrison, Melissa C Southey, Graham G Giles

2016-01-01

AIM: To examine whether peripheral blood methylation is associated with risk of developing mature B-cell neoplasms (MBCNs). MATERI..

Alcohol consumption for different periods in life, intake pattern over time and all-cause mortality

Harindra Jayasekara, Robert J MacInnis, Allison M Hodge, John L Hopper, Graham G Giles, Robin Room, Dallas R English

2015-12-01

BACKGROUND: Conventionally, cohort studies have assessed the association between alcohol and all-cause mortality by using alcohol ..

A large infrapatellar fat pad protects against knee pain and lateral tibial cartilage volume loss

Andrew J Teichtahl, Ema Wulidasari, Sharmayne RE Brady, Yuanyuan Wang, Anita Wluka, Changhai Ding, Graham G Giles, Flavia M Cicuttini

2015-11-10

INTRODUCTION: The infrapatellar fat pad (IPFP) is commonly resected during knee joint arthroplasty, but the ramifications of doing..

Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies

Timothy J Key, Paul N Appleby, Ruth C Travis, Demetrius Albanes, Anthony J Alberg, Aurelio Barricarte, Amanda Black, Heiner Boeing, H Bas Bueno-de-Mesquita, June M Chan, Chu Chen, Michael B Cook, Jenny L Donovan, Pilar Galan, Rebecca Gilbert, Graham G Giles, Edward Giovannucci, Gary E Goodman, Phyllis J Goodman, Marc J Gunter

2015-11-01

BACKGROUND: Individual studies have suggested that circulating carotenoids, retinol, or tocopherols may be associated with prostat..

Fine-Scale Mapping of the 4q24 Locus Identifies Two Independent Loci Associated with Breast Cancer Risk

Xingyi Guo, Jirong Long, Chenjie Zeng, Kyriaki Michailidou, Maya Ghoussaini, Manjeet K Bolla, Qin Wang, Roger L Milne, Xiao-Ou Shu, Qiuyin Cai, Jonathan Beesley, Siddhartha P Kar, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Matthias W Beckmann, Alicia Beeghly-Fadiel, Javier Benitez, William Blot, Natalia Bogdanova

2015-11-01

BACKGROUND: A recent association study identified a common variant (rs9790517) at 4q24 to be associated with breast cancer risk. I..

Age Related Macular Degeneration and Total Hip Replacement Due to Osteoarthritis or Fracture: Melbourne Collaborative Cohort Study

Elaine W Chong, Yuanyuan Wang, Liubov D Robman, Khin Zaw Aung, Galina A Makeyeva, Graham G Giles, Stephen Graves, Flavia M Cicuttini, Robyn H Guymer

2015-09-10

Osteoarthritis is the leading cause of total hip replacement, accounting for more than 80% of all total hip replacements. Emerging..

A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density

Anja Rudolph, Peter A Fasching, Sabine Behrens, Ursula Eilber, Manjeet K Bolla, Qin Wang, Deborah Thompson, Kamila Czene, Judith S Brand, Jingmei Li, Christopher Scott, V Shane Pankratz, Kathleen Brandt, Emily Hallberg, Janet E Olson, Adam Lee, Matthias W Beckmann, Arif B Ekici, Lothar Haeberle, Gertraud Maskarinec

2015-08-16

INTRODUCTION: Mammographic density is an established breast cancer risk factor with a strong genetic component and can be increase..

AGE-RELATED MACULAR DEGENERATION PHENOTYPES ASSOCIATED WITH MUTUALLY EXCLUSIVE HOMOZYGOUS RISK VARIANTS IN CFH AND HTRA1 GENES

Elaine W Chong, Fakir M Amirul Islam, Liubov D Robman, Khin Zaw Aung, Andrea J Richardson, Paul N Baird, Robyn H Guymer

2015-05-01

PURPOSE: To determine age-related macular degeneration (AMD) phenotypes associated with mutually exclusive homozygotic risk varian..

Early cartilage abnormalities at the hip are associated with obesity and body composition measures - a 3.0T MRI community-based study

Andrew J Teichtahl, Yuanyuan Wang, Sam Smith, Anita Wluka, Donna Urquhart, Graham G Giles, Sultana Monira Hussain, Flavia M Cicuttini

2015-04-22

INTRODUCTION: Although obesity is a risk factor for hip osteoarthritis (OA), the role of body composition, if any, is unclear. Thi..

Age-Related Macular Degeneration in Ethnically Diverse Australia: Melbourne Collaborative Cohort Study

Liubov D Robman, Fakir MA Islam, Elaine WT Chong, Madeleine KM Adams, Julie A Simpson, Khin Zaw Aung, Galina A Makeyeva, John L Hopper, Dallas R English, Graham G Giles, Paul N Baird, Robyn H Guymer

2015-04-01

PURPOSE: To determine and compare the prevalence of age-related macular degeneration (AMD) in older Australians of Anglo-Celtic an..

Natural history of HFE simple heterozygosity for C282Y and H63D: A prospective 12-year study

Sophie G Zaloumis, Katrina J Allen, Nadine A Bertalli, Lidija Turkovic, Martin B Delatycki, Amanda J Nicoll, Christine E McLaren, Dallas R English, John L Hopper, Graham G Giles, Gregory J Anderson, John K Olynyk, Lawrie W Powell, Lyle C Gurrin

2015-04-01

BACKGROUND AND AIM: The risk of hemochromatosis-related morbidity for HFE simple heterozygosity for either the C282Y or H63D subst..

Development and Validation of a Risk Score Predicting Risk of Colorectal Cancer

Annika Steffen, Robert J MacInnis, Grace Joshy, Graham G Giles, Emily Banks, David Roder

2014-11-01

BACKGROUND: Quantifying the risk of colorectal cancer for individuals is likely to be useful for health service provision. Our aim..

Seasonality of cardiovascular risk factors: an analysis including over 230 000 participants in 15 countries

Helena Marti-Soler, Cedric Gubelmann, Stefanie Aeschbacher, Luis Alves, Martin Bobak, Vanina Bongard, Els Clays, Giovanni de Gaetano, Augusto Di Castelnuovo, Roberto Elosua, Jean Ferrieres, Idris Guessous, Jannicke Igland, Torben Jorgensen, Yuri Nikitin, Mark G O'Doherty, Luigi Palmieri, Rafel Ramos, Judith Simons, Gerhard Sulo

2014-10-01

OBJECTIVE: To assess the seasonality of cardiovascular risk factors (CVRF) in a large set of population-based studies. METHODS: Cr..

Association between obesity and magnetic resonance imaging defined patellar tendinopathy in community-based adults: a cross-sectional study

Jessica Fairley, Jason Toppi, Flavia M Cicuttini, Anita Wluka, Graham G Giles, Jill Cook, Richard O'Sullivan, Yuanyuan Wang

2014-08-07

BACKGROUND: Patellar tendinopathy is a common cause of activity-related anterior knee pain. Evidence is conflicting as to whether ..

Change in Body Size and Mortality: Results from the Melbourne Collaborative Cohort Study

Amalia Karahalios, Julie A Simpson, Laura Baglietto, Robert J MacInnis, Allison M Hodge, Graham G Giles, Dallas R English

2014-07-02

BACKGROUND: The association between change in weight or body mass index, and mortality is widely reported, however, both measures ..

Association between index-to-ring finger length ratio and risk of severe knee and hip osteoarthritis requiring total joint replacement

Sultana Monira Hussain, Yuanyuan Wang, David C Muller, Anita Wluka, Graham G Giles, John T Manning, Stephen Graves, Flavia M Cicuttini

2014-07-01

OBJECTIVE: The data are conflicting for the association between the index-to-ring finger length ratio (2D:4D) and the risk of OA. ..

Risk of Ovarian Cancer and the NF-kappa B Pathway: Genetic Association with IL1A and TNFSF10

Bridget Charbonneau, Matthew S Block, William R Bamlet, Robert A Vierkant, Kimberly R Kalli, Zachary Fogarty, David N Rider, Thomas A Sellers, Shelley S Tworoger, Elizabeth Poole, Harvey A Risch, Helga B Salvesen, Lambertus A Kiemeney, Laura Baglietto, Graham G Giles, Gianluca Severi, Britton Trabert, Nicolas Wentzensen, Georgia Chenevix-Trench, Alice S Whittemore

2014-02-01

A missense single-nucleotide polymorphism (SNP) in the immune modulatory gene IL1A has been associated with ovarian cancer risk (r..

Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study

Nichola Johnson, Frank Dudbridge, Nick Orr, Lorna Gibson, Michael E Jones, Minouk J Schoemaker, Elizabeth J Folkerd, Ben P Haynes, John L Hopper, Melissa C Southey, Gillian S Dite, Carmel Apicella, Marjanka K Schmidt, Annegien Broeks, Laura J Van't Veer, Femke Atsma, Kenneth Muir, Artitaya Lophatananon, Peter A Fasching, Matthias W Beckmann

2014-01-01

INTRODUCTION: We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22..

Dietary intake of B vitamins and methionine and breast cancer risk

Julie K Bassett, Laura Baglietto, Allison M Hodge, Gianluca Severi, John L Hopper, Dallas R English, Graham G Giles

2013-08-01

PURPOSE: We investigated prospectively the relationship between dietary intakes of methionine and B vitamins associated with one-c..

THE PREVALENCE AND RISK FACTORS OF EPIRETINAL MEMBRANES The Melbourne Collaborative Cohort Study

Khin Z Aung, Galina Makeyeva, Madeleine K Adams, Elaine W-T Chong, Lucy Busija, Graham G Giles, Dallas R English, John Hopper, Paul N Baird, Robyn H Guymer, Liubov D Robman

2013-05-01

PURPOSE: To determine the prevalence of epiretinal membranes (ERMs) in Melbourne, Australia and its risk factors in this populatio..

Confirmation of the reduction of hormone replacement therapy-related breast cancer risk for carriers of the HSD17B1_937_G variant

Ofure Obazee, Christina Justenhoven, Stefan Winter, Jenny Chang-Claude, Anja Rudolph, Petra Seibold, Dieter Flesch-Janys, Ulf Hannelius, Jingmei Li, Keith Humphreys, Per Hall, Graham Giles, Gianluca Severi, Laura Baglietto, Melissa Southey, Sylvia Rabstein, Volker Harth, Anne Lotz, Beate Pesch, Thomas Bruening

2013-04-01

17β-hydroxysteroid dehydrogenase type 1 (HSD17B1) plays an important role in the biosynthesis of 17β-estradiol. The current study ..

Effect of Long-Term Vigorous Physical Activity on Healthy Adult Knee Cartilage

Andrew J Teichtahl, Anita Wluka, Yuanyuan Wang, Andrew Forbes, Miranda L Davies-Tuck, Dallas R English, Graham G Giles, Flavia M Cicuttini

2012-06-01

INTRODUCTION: Whether participation in long-term vigorous physical activity affects knee cartilage is unclear and may depend on th..

A Flatter Proximal Trochlear Groove Is Associated with Patella Cartilage Loss

Andrew J Teichtahl, Fahad Hanna, Anita Wluka, Donna M Urquhart, Yuanyuan Wang, Dallas R English, Graham G Giles, Flavia M Cicuttini

2012-03-01

PURPOSE: The bony articular surface contributes to a joint's congruency, and it might be a determinant of structural change. The a..

Second to fourth digit ratio (2D:4D) and concentrations of circulating sex hormones in adulthood

David C Muller, Graham G Giles, Julie Bassett, Howard A Morris, John T Manning, John L Hopper, Dallas R English, Gianluca Severi

2011-04-27

BACKGROUND: The second to fourth digit ratio (2D:4D) is used as a marker of prenatal sex hormone exposure. The objective of this s..

Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study

Roger L Milne, Mia M Gaudet, Amanda B Spurdle, Peter A Fasching, Fergus J Couch, Javier Benitez, Jose Ignacio Arias Perez, M Pilar Zamora, Nuria Malats, Isabel dos Santos Silva, Lorna J Gibson, Olivia Fletcher, Nichola Johnson, Hoda Anton-Culver, Argyrios Ziogas, Jonine Figueroa, Louise Brinton, Mark E Sherman, Jolanta Lissowska, John L Hopper

2010-01-01

INTRODUCTION: Several common breast cancer genetic susceptibility variants have recently been identified. We aimed to determine ho..