Targeted mining for new drugs against parasitic nematodes of animals a synergy of integrated frontier technologies and a committed partnership

Structural and functional characterisation of the fork head transcription factor-encoding gene, Hc-daf-16, from the parasitic nematode Haemonchus contortus (Strongylida)

Min Hu, James B Lok, Najju Ranjit, Holman C Massey, Paul W Sternberg, Robin B Gasser

2010-03-15

Despite their phylogenetic diversity, parasitic nematodes share attributes of longevity and developmental arrest (=hypobiosis) wit..

Advanced in silico analysis of expressed sequence tag (EST) data for parasitic nematodes of major socio-economic importance - Fundamental insights toward biotechnological outcomes

Shoba Ranganathan, Ranjeeta Menon, Robin B Gasser

2009-07-01

Parasitic nematodes infect humans, other animals and plants, and impose a significant public health and economic burden worldwide ..

Molecular and phylogenetic characterization of cytochromes c from Haemonchus contortus and Trichostrongylus vitrinus (Nematoda: Trichostrongylida)

BE Campbell, Aj Nisbet, J Mulvenna, A Loukas, RB Gasser

2008-11-15

Although cytochrome c genes (cyt c) and proteins (CYT C) have been relatively well studied in mammals, very little is known about ..

Tv-RIO1-an atypical protein kinase from the parasitic nematode Trichostrongylus vitrinus

Min Hu, Nicole LaRonde-LeBlanc, Paul W Sternberg, Robin B Gasser

2008-09-22

UNLABELLED: BACKGROUND: Protein kinases are key enzymes that regulate a wide range of cellular processes, including cell-cycle pr..

Gender-enriched transcripts in Haemonchus contortus - predicted functions and genetic interactions based on comparative analyses with Caenorhabditis elegans

Bronwyn E Campbell, Shivashankar H Nagaraj, Min Hu, Weiwei Zhong, Paul W Sternberg, Eng K Ong, Alex Loukas, Shoba Ranganathan, Ian Beveridge, Russell L McInnes, Gareth W Hutchinson, Robin B Gasser

2008-01-01

In the present study, a bioinformatic-microarray approach was employed for the analysis of selected expressed sequence tags (ESTs)..

In silico analysis of expressed sequence tags from Trichostrongylus vitrinus (Nematoda): comparison of the automated ESTExplorer workflow platform with conventional database searches

Shivashankar H Nagaraj, Robin B Gasser, Alasdair J Nisbet, Shoba Ranganathan

2008-01-01

BACKGROUND: The analysis of expressed sequence tags (EST) offers a rapid and cost effective approach to elucidate the transcriptom..

A transcriptomic analysis of the adult stage of the bovine lungworm, Dictyocaulus viviparus

Shoba Ranganathan, Shivashankar H Nagaraj, Min Hu, Christina Strube, Thomas Schnieder, Robin B Gasser

2007-09-05

BACKGROUND: Lungworms of the genus Dictyocaulus (family Dictyocaulidae) are parasitic nematodes of major economic importance. They..

Trichostrongylus vitrinus (Nematoda : Strongylida): Molecular characterization and transcriptional analysis of Tv-stp-1, a serine/threonine phosphatase gene

Min Hu, Youssef G Abs El-Osta, Bronwyn E Campbell, Peter R Boag, Alasdair J Nisbet, Ian Beveridge, Robin B Gasser

2007-09-01

A full-length cDNA (Tv-stp-1) encoding a serine/threonine protein phosphatase (Tv-STP-1) was isolated from Trichostrongylus vitrin..

Genomic characterization of Tv-ant-1, a Caenorhabditis elegans tag-61 homologue from the parasitic nematode Trichostrongylus vitrinus

Min Hu, Bronwyn E Campbell, Mark Pellegrino, Alex Loukas, Ian Beveridge, Shoba Ranuanathan, Robin B Gasser

2007-08-01

A full-length cDNA (Tv-ant-1) encoding an adenine nucleotide translocator (ANT or ADP/ATP translocase) (Tv-ANT-1) was isolated fro..

ESTExplorer: an expressed sequence tag (EST) assembly and annotation platform

Shivashankar H Nagaraj, Nandan Deshpande, Robin B Gasser, Shoba Ranganathan

2007-07-01

The analysis of expressed sequence tag (EST) datasets offers a rapid and cost-effective approach to elucidate the transcriptome of..

Gene discovery for the carcinogenic human liver fluke, Opisthorchis viverrini

Thewarach Laha, Porntip Pinlaor, Jason Mulvenna, Banchob Sripa, Manop Sripa, Michael J Smout, Robin B Gasser, Paul J Brindley, Alex Loukas

2007-06-22

BACKGROUND: Cholangiocarcinoma (CCA)--cancer of the bile ducts--is associated with chronic infection with the liver fluke, Opistho..

Oesophagostomum dentatum - Potential as a model for genomic studies of strongylid nematodes, with biotechnological prospects

Robin B Gasser, Pauline Cottee, Alasdair J Nisbet, Baerbel Ruttkowski, Shoba Ranganathan, Anja Joachim

2007-05-01

There are substantial gaps in the knowledge of the molecular processes of development and reproduction in parasitic nematodes, des..

A hitchhiker's guide to expressed sequence tag (EST) analysis

Shivashankar H Nagaraj, Robin B Gasser, Shoba Ranganathan

2007-01-01

Expressed sequence tag (EST) sequencing projects are underway for numerous organisms, generating millions of short, single-pass nu..

Haemonchus contortus: Prokaryotic expression and enzyme activity of recombinant HcSTK, a serine/threonine protein kinase

Sia Nikolaou, Dadna Hartman, Alasdair J Nisbet, Robin B Gasser

2006-08-01

Members of the PAR-1/MARK serine/threonine protein kinase (STK) subfamily are important regulators of the cytoskeleton, and their ..

Isolation and characterization of class II myosin genes from Haemonchus contortus

M Hu, NB Chilton, D Hartman, AJ Nisbet, PJA Presidente, RB Gasser

2006-07-01

In this study, cDNAs encoding myosin from the parasitic nematode Haemonchus contortus were isolated and characterized. Several exh..

Prospects for exploring molecular developmental processes in Haemonchus contortus

S Nikolaou, RB Gasser

2006-07-01

Haemonchus contortus of small ruminants is a parasitic nematode of major socio-economic importance world-wide. While there is cons..

Ubiquitin-conjugating enzyme genes in Oesophagostomum dentatum

Pauline A Cottee, Youssef G Abs El-Osta, Alasdair J Nisbet, Robin B Gasser

2006-07-01

Full-length genes representing different isoforms of the ubiquitin-conjugating enzyme UBC-2 were isolated from Oesophagostomum den..

A survey of the intestinal transcriptomes of the hookworms, Necator americanus and Ancylostoma caninum, using tissues isolated by laser microdissection microscopy

N Ranjit, MK Jones, DJ Stenzel, RB Gasser, A Loukas

2006-05-01

Class II myosins in nematodes - genetic relationships, fundamental and applied implications

S Nikolaou, M Hu, NB Chilton, D Hartman, AJ Nisbet, PJA Presidente, RB Gasser

2006-05-01

Myosins are represented by a wide range of different classes of molecule, of which the most extensively studied are the class II m..