Targeted mining for new drugs against parasitic nematodes of animals a synergy of integrated frontier technologies and a committed partnership
Grant number: LP0667795
This project will: develop a quality scientific and technological program in national priority areas, leading to a strong basic research, new concepts and the enhanced international collaborative links; strengthen links between basic and applied research, and academia and industry; develop excellence via pan-Australian collaborations, resulting in a more efficient use of resources in a national and international context; enhance the skills-base in biology, biotechnology and bioinformatics; increase global visibility with increased investment in Australian science; improved animal welfare and production via better control of infectious diseases; commercial products with benefits to agricultur..View full description
Related publications (19)
Structural and functional characterisation of the fork head transcription factor-encoding gene, Hc-daf-16, from the parasitic nematode Haemonchus contortus (Strongylida)
Min Hu, James B Lok, Najju Ranjit, Holman C Massey, Paul W Sternberg, Robin B Gasser
Despite their phylogenetic diversity, parasitic nematodes share attributes of longevity and developmental arrest (=hypobiosis) wit..
Advanced in silico analysis of expressed sequence tag (EST) data for parasitic nematodes of major socio-economic importance - Fundamental insights toward biotechnological outcomes
Shoba Ranganathan, Ranjeeta Menon, Robin B Gasser
Parasitic nematodes infect humans, other animals and plants, and impose a significant public health and economic burden worldwide ..
Molecular and phylogenetic characterization of cytochromes c from Haemonchus contortus and Trichostrongylus vitrinus (Nematoda: Trichostrongylida)
BE Campbell, Aj Nisbet, J Mulvenna, A Loukas, RB Gasser
Although cytochrome c genes (cyt c) and proteins (CYT C) have been relatively well studied in mammals, very little is known about ..
Gender-enriched transcripts in Haemonchus contortus - predicted functions and genetic interactions based on comparative analyses with Caenorhabditis elegans
Bronwyn E Campbell, Shivashankar H Nagaraj, Min Hu, Weiwei Zhong, Paul W Sternberg, Eng K Ong, Alex Loukas, Shoba Ranganathan, Ian Beveridge, Russell L McInnes, Gareth W Hutchinson, Robin B Gasser
In the present study, a bioinformatic-microarray approach was employed for the analysis of selected expressed sequence tags (ESTs)..
In silico analysis of expressed sequence tags from Trichostrongylus vitrinus (Nematoda): comparison of the automated ESTExplorer workflow platform with conventional database searches
Shivashankar H Nagaraj, Robin B Gasser, Alasdair J Nisbet, Shoba Ranganathan
BACKGROUND: The analysis of expressed sequence tags (EST) offers a rapid and cost effective approach to elucidate the transcriptom..
A transcriptomic analysis of the adult stage of the bovine lungworm, Dictyocaulus viviparus
Shoba Ranganathan, Shivashankar H Nagaraj, Min Hu, Christina Strube, Thomas Schnieder, Robin B Gasser
BACKGROUND: Lungworms of the genus Dictyocaulus (family Dictyocaulidae) are parasitic nematodes of major economic importance. They..
Trichostrongylus vitrinus (Nematoda : Strongylida): Molecular characterization and transcriptional analysis of Tv-stp-1, a serine/threonine phosphatase gene
Min Hu, Youssef G Abs El-Osta, Bronwyn E Campbell, Peter R Boag, Alasdair J Nisbet, Ian Beveridge, Robin B Gasser
A full-length cDNA (Tv-stp-1) encoding a serine/threonine protein phosphatase (Tv-STP-1) was isolated from Trichostrongylus vitrin..
Genomic characterization of Tv-ant-1, a Caenorhabditis elegans tag-61 homologue from the parasitic nematode Trichostrongylus vitrinus
Min Hu, Bronwyn E Campbell, Mark Pellegrino, Alex Loukas, Ian Beveridge, Shoba Ranuanathan, Robin B Gasser
A full-length cDNA (Tv-ant-1) encoding an adenine nucleotide translocator (ANT or ADP/ATP translocase) (Tv-ANT-1) was isolated fro..
Gene discovery for the carcinogenic human liver fluke, Opisthorchis viverrini
Thewarach Laha, Porntip Pinlaor, Jason Mulvenna, Banchob Sripa, Manop Sripa, Michael J Smout, Robin B Gasser, Paul J Brindley, Alex Loukas
BACKGROUND: Cholangiocarcinoma (CCA)--cancer of the bile ducts--is associated with chronic infection with the liver fluke, Opistho..
Oesophagostomum dentatum - Potential as a model for genomic studies of strongylid nematodes, with biotechnological prospects
Robin B Gasser, Pauline Cottee, Alasdair J Nisbet, Baerbel Ruttkowski, Shoba Ranganathan, Anja Joachim
There are substantial gaps in the knowledge of the molecular processes of development and reproduction in parasitic nematodes, des..
Haemonchus contortus: Prokaryotic expression and enzyme activity of recombinant HcSTK, a serine/threonine protein kinase
Sia Nikolaou, Dadna Hartman, Alasdair J Nisbet, Robin B Gasser
Members of the PAR-1/MARK serine/threonine protein kinase (STK) subfamily are important regulators of the cytoskeleton, and their ..
Class II myosins in nematodes - genetic relationships, fundamental and applied implications
S Nikolaou, M Hu, NB Chilton, D Hartman, AJ Nisbet, PJA Presidente, RB Gasser
Myosins are represented by a wide range of different classes of molecule, of which the most extensively studied are the class II m..