Understanding T cell responses to mutant influenza viruses

Grant number: 454312 | Funding period: 2007 - 2009

Completed

Abstract

T cells are a critical component of the immune system after infection with viruses. In particular, virus-specific CD8+ T cells can clear viral infections by killing virally-infected cells and the release of immunomodulators. These are called effector T cells. After the viral infection is cleared, a small proportion of T cells (around 5 to 10%) survives for many years and constitute a memory pool of virus-specific T cells. Memory T cells provide a rapid and effective protection in case of a repeated infection with the same virus, and hence result in a less severe disease. However, viruses often mutate their genes to escape such efficient T cell responses. In this study, we will investigate T ..

View full description

Related publications (7)

Scholarly works icon

Memory precursor phenotype of CD8( ) T cells reflects early antigenic experience rather than memory numbers in a model of localized acute influenza infection

Hayley A Croom, Alice E Denton, Sophie A Valkenburg, Natasha G Swan, Matthew R Olson, Stephen J Turner, Peter C Doherty, Katherine Kedzierska

2011-03-01

The mechanistic basis of memory T-cell development is poorly defined. Phenotypic markers that define precursors at effector stages..

Scholarly works icon

Fixing an irrelevant TCR alpha chain reveals the importance of TCR beta diversity for optimal TCR alpha beta pairing and function of virus-specific CD8( ) T cells

Sophie A Valkenburg, E Bridie Day, Natasha G Swan, Hayley A Croom, Francis R Carbone, Peter C Doherty, Stephen J Turner, Katherine Kedzierska

2010-09-01

TCR repertoire diversity can influence the efficacy of CD8(+) T-cell populations, with greater breadth eliciting better protection..

Scholarly works icon

Multiplexed combinatorial tetramer staining in a mouse model of virus infection

Tania Cukalac, Sophie A Valkenburg, Nicole L La Gruta, Stephen J Turner, Peter C Doherty, Katherine Kedzierska

2010-08-31

Use of fluorescently labelled multimers, particularly tetramers of peptide and MHC class I glycoprotein (pMHC-I) complexes, is ess..

Scholarly works icon

Protective Efficacy of Cross-Reactive CD8( ) T Cells Recognising Mutant Viral Epitopes Depends on Peptide-MHC-I Structural Interactions and T Cell Activation Threshold

Sophie A Valkenburg, Stephanie Gras, Carole Guillonneau, Nicole L La Gruta, Paul G Thomas, Anthony W Purcell, Jamie Rossjohn, Peter C Doherty, Stephen J Turner, Katherine Kedzierska

2010-08-01

Emergence of a new influenza strain leads to a rapid global spread of the virus due to minimal antibody immunity. Pre-existing CD8..

Scholarly works icon

Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion

Nicole L La Gruta, William T Rothwell, Tania Cukalac, Natasha G Swan, Sophie A Valkenburg, Katherine Kedzierska, Paul G Thomas, Peter C Doherty, Stephen J Turner

2010-06-01

CD8+ T cell responses to viral infection are characterized by the emergence of dominant and subdominant CTL populations. The immun..

Scholarly works icon

Diversity and clonotypic composition of influenza-specific CD8( ) TCR repertoires remain unaltered in the absence of Aire

Katherine Kedzierska, Sophie A Valkenburg, Carole Guillonneau, Francois-Xavier Hubert, Tania Cukalac, Joan M Curtis, John Stambas, Hamish S Scott, Lukasz Kedzierski, Vanessa Venturi, Miles P Davenport

2010-03-01

TCR repertoire diversity is important for the protective efficacy of CD8(+) T cells, limiting viral escape and cross-reactivity be..

Scholarly works icon

Complete modification of TCR specificity and repertoire selection does not perturb a CD8( ) T cell immunodominance hierarchy

Katherine Kedzierska, Carole Guillonneau, Stephanie Gras, Lauren A Hatton, Richard Webby, Anthony W Purcell, Jamie Rossjohn, Peter C Doherty, Stephen J Turner

2008-12-09

Understanding T cell immunodominance hierarchies is fundamental to the development of cellular-based vaccines and immunotherapy. A..

University of Melbourne Researchers