Understanding T cell responses to mutant influenza viruses
Grant number: 454312 | Funding period: 2007 - 2009
T cells are a critical component of the immune system after infection with viruses. In particular, virus-specific CD8+ T cells can clear viral infections by killing virally-infected cells and the release of immunomodulators. These are called effector T cells. After the viral infection is cleared, a small proportion of T cells (around 5 to 10%) survives for many years and constitute a memory pool of virus-specific T cells. Memory T cells provide a rapid and effective protection in case of a repeated infection with the same virus, and hence result in a less severe disease. However, viruses often mutate their genes to escape such efficient T cell responses. In this study, we will investigate T ..View full description
Related publications (7)
Memory precursor phenotype of CD8( ) T cells reflects early antigenic experience rather than memory numbers in a model of localized acute influenza infection
Hayley A Croom, Alice E Denton, Sophie A Valkenburg, Natasha G Swan, Matthew R Olson, Stephen J Turner, Peter C Doherty, Katherine Kedzierska
The mechanistic basis of memory T-cell development is poorly defined. Phenotypic markers that define precursors at effector stages..
Fixing an irrelevant TCR alpha chain reveals the importance of TCR beta diversity for optimal TCR alpha beta pairing and function of virus-specific CD8( ) T cells
Sophie A Valkenburg, E Bridie Day, Natasha G Swan, Hayley A Croom, Francis R Carbone, Peter C Doherty, Stephen J Turner, Katherine Kedzierska
TCR repertoire diversity can influence the efficacy of CD8(+) T-cell populations, with greater breadth eliciting better protection..
Multiplexed combinatorial tetramer staining in a mouse model of virus infection
Tania Cukalac, Sophie A Valkenburg, Nicole L La Gruta, Stephen J Turner, Peter C Doherty, Katherine Kedzierska
Use of fluorescently labelled multimers, particularly tetramers of peptide and MHC class I glycoprotein (pMHC-I) complexes, is ess..
Protective Efficacy of Cross-Reactive CD8( ) T Cells Recognising Mutant Viral Epitopes Depends on Peptide-MHC-I Structural Interactions and T Cell Activation Threshold
Sophie A Valkenburg, Stephanie Gras, Carole Guillonneau, Nicole L La Gruta, Paul G Thomas, Anthony W Purcell, Jamie Rossjohn, Peter C Doherty, Stephen J Turner, Katherine Kedzierska
Emergence of a new influenza strain leads to a rapid global spread of the virus due to minimal antibody immunity. Pre-existing CD8..
Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion
Nicole L La Gruta, William T Rothwell, Tania Cukalac, Natasha G Swan, Sophie A Valkenburg, Katherine Kedzierska, Paul G Thomas, Peter C Doherty, Stephen J Turner
CD8+ T cell responses to viral infection are characterized by the emergence of dominant and subdominant CTL populations. The immun..
Diversity and clonotypic composition of influenza-specific CD8( ) TCR repertoires remain unaltered in the absence of Aire
Katherine Kedzierska, Sophie A Valkenburg, Carole Guillonneau, Francois-Xavier Hubert, Tania Cukalac, Joan M Curtis, John Stambas, Hamish S Scott, Lukasz Kedzierski, Vanessa Venturi, Miles P Davenport
TCR repertoire diversity is important for the protective efficacy of CD8(+) T cells, limiting viral escape and cross-reactivity be..
Complete modification of TCR specificity and repertoire selection does not perturb a CD8( ) T cell immunodominance hierarchy
Katherine Kedzierska, Carole Guillonneau, Stephanie Gras, Lauren A Hatton, Richard Webby, Anthony W Purcell, Jamie Rossjohn, Peter C Doherty, Stephen J Turner
Understanding T cell immunodominance hierarchies is fundamental to the development of cellular-based vaccines and immunotherapy. A..