Understanding The Pathophysiology Of Gestational Diabetes Mellitus

Grant number: 454310 | Funding period: 2007 - 2010

Completed

Abstract

Gestational Diabetes Mellitus (GDM), which is defined as glucose intolerance of variable severity with onset or first recognition during pregnancy, affects 5% to 8% of pregnancies, and represents more than 10,000 women annually in Australia. The overall aim of this project is to increase our understanding of the causes of gestational diabetes. In particular, the role of various inflammatory pathways in the biochemical mechanisms involved in insulin resistance associated with GDM will be examined, with these pathways representing novel approaches to developing agents for efficacious clinical management strategies for the management of GDM. Although major advances have been made in our underst..

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