Age-related response to heparin in children.
Grant number: 454385 | Funding period: 2007 - 2010
Unfractionated Heparin (UFH) is the most commonly used anticoagulant (blood thinning drug) in children. Despite this, the clinical evidence, in terms of reported treatment failures and bleeding complications, suggests the drug is used suboptimally in children compared to adults.This likely relfects the lack of specific studies of UFH in children. This study will, for the first time, define the pharmacokinetics-dynamics of UFH in children, allowing age-specific protocols to be developed. Pharmacological modelling of this data will likely have implications for the use of other anticoagulants in children.
Related publications (7)
Novel interactions between UFH and TFPI in children
Fiona Newall, Linda Johnston, Robyn Summerhayes, Geoff Lane, Noel Cranswick, Paul Monagle, Vera Ignjatovic
The impact of age upon therapeutic response to unfractionated heparin (UFH) in children is proposed to reflect quantitative and po..
Clinical use of unfractionated heparin therapy in children: time for change?
Fiona Newall, Vera Ignjatovic, Linda Johnston, Robyn Summerhayes, Geoff Lane, Noel Cranswick, Paul Monagle
Paediatric recommendations for unfractionated heparin (UFH) management are extrapolated from adult trials, a practice that may con..
Age-related plasma reference ranges for two heparin-binding proteins - vitronectin and platelet factor 4
F Newall, L Johnston, V Ignjatovic, R Summerhayes, P Monagle
This study was conducted to establish age-related reference ranges for two heparin-binding proteins--vitronectin and platelet fact..
In vivo age dependency of unfractionated heparin in infants and children
Fiona Newall, Vera Ignjatovic, Robyn Summerhayes, Andrew Gan, Warwick Butt, Linda Johnston, Paul Monagle
INTRODUCTION: Unfractionated Heparin (UFH) is used widely in paediatrics. Paediatric specific recommendations for UFH therapy are ..