Relaxin Family Peptide Receptors

Grant number: 454375 | Funding period: 2007 - 2009

Completed

Abstract

Relaxin is a hormone which has long been known to have essential roles in pregnancy and birth. However it has also been demonstrated to have far broader involvement in the functioning of the kidney, heart and central nervous system. It is currently in clinical trials with our commercial partner BAS Medical for the treatment of congestive heart failure, cervical ripening and preeclampsia. Furthermore, relaxin shows enormous promise as an antifibrotic agent which has far-reaching therapeutic consequences since fibrosis is a hallmark of all forms of progressive cardiovascular and renal disease and obstructive airway disease (asthma), which collectively contribute to 40-50% of deaths in develope..

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Related publications (10)

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AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts: Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis

Bryna SM Chow, Martina Kocan, Matthew Shen, Yan Wang, Lei Han, Jacqueline Y Chew, Chao Wang, Sanja Bosnyak, Katrina M Mirabito-Colafella, Giannie Barsha, Belinda Wigg, Elizabeth KM Johnstone, Mohammed A Hossain, Kevin DG Pfleger, Kate M Denton, Robert E Widdop, Roger J Summers, Ross AD Bathgate, Tim D Hewitson, Chrishan S Samuel

2019-11-01

BACKGROUND: Recombinant human relaxin-2 (serelaxin), which has organ-protective actions mediated via its cognate G protein-coupled..

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Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis

Bryna S Man Chow, Martina Kocan, Sanja Bosnyak, Mohsin Sarwar, Belinda Wigg, Emma S Jones, Robert E Widdop, Roger J Summers, Ross AD Bathgate, Tim D Hewitson, Chrishan S Samuel

2014-07-01

Fibrosis is a hallmark of chronic kidney disease, for which there is currently no effective cure. The hormone relaxin is emerging ..

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Signalling profiles of H3 relaxin, H2 relaxin and R3(B.23-27) R/I5 acting at the relaxin family peptide receptor 3 (RXFP3)

M Kocan, M Sarwar, MA Hossain, JD Wade, RJ Summers

2014-06-01

BACKGROUND AND PURPOSE: Relaxin family peptide receptor 3 (RXFP3) is expressed in brain areas important for processing sensory inf..

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The Different Ligand-Binding Modes of Relaxin Family Peptide Receptors RXFP1 and RXFP2

Daniel J Scott, K Johan Rosengren, Ross AD Bathgate

2012-11-01

Relaxin and insulin-like peptide 3 (INSL3) are peptide hormones with a number of important physiological roles in reproduction, re..

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Recombinant expression of an insulin-like peptide 3 (INSL3) precursor and its enzymatic conversion to mature human INSL3

Xiao Luo, Ross AD Bathgate, Ya-Li Liu, Xiao-Xia Shao, John D Wade, Zhan-Yun Guo

2009-09-01

Insulin-like peptide 3 (INSL3), which is primarily expressed in the Leydig cells of the testes, is a member of the insulin superfa..

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Addition of a Carboxy-Terminal Green Fluorescent Protein Does Not Alter the Binding and Signaling Properties of Relaxin Family Peptide Receptor 3

Emma T van der Westhuizen, John D Wade, Patrick M Sexton, Roger J Summers

2009-01-01

The relaxin family peptide receptor 3 (RXFP3) is the cognate receptor for the neuropeptide relaxin-3. RXFP3 was tagged at the carb..

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Development and Optimization of MicroRNA against Relaxin-3

Gabrielle E Callander, Walter G Thomas, Ross AD Bathgate

2009-01-01

Recent in vivo studies suggest a role for relaxin-3 in feeding and stress. To further elucidate the function of relaxin-3 in the c..

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Modeling the Primary Hormone-Binding Site of RXFP1 and RXFP2

Daniel J Scott, Geoffrey W Tregear, Ross AD Bathgate

2009-01-01

The primary binding sites of the relaxin and insulin-like peptide 3 (INSL3) receptors, RXFP1 and RXFP2, are found within the leuci..

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Resolving the Unconventional Mechanisms Underlying RXFP1 and RXFP2 Receptor Function

Brigham J Hartley, Daniel J Scott, Gabrielle E Callander, Tracey N Wilkinson, Despina E Ganella, Chze K Kong, Sharon Layfield, Tania Ferraro, Emma J Petrie, Ross AD Bathgate

2009-01-01

The receptors for relaxin and insulin-like peptide 3 (INSL3) are now well-characterized as the relaxin family peptide (RXFP) recep..

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Structure and Activity in the Relaxin Family of Peptides

Geoffrey W Tregear, Ross AD Bathgate, Mohammed Akhter Hossain, Feng Lin, Suode Zhang, Fazel Shabanpoor, Daniel J Scott, Sherie Ma, Andrew L Gundlach, Chrishan S Samuel, John D Wade

2009-01-01

The availability of improved peptide synthesis procedures, convenient and sensitive assays for receptor binding and activation, to..

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