Relaxin Family Peptide Receptors

Abstract

Relaxin is a hormone which has long been known to have essential roles in pregnancy and birth. However it has also been demonstrated to have far broader involvement in the functioning of the kidney, heart and central nervous system. It is currently in clinical trials with our commercial partner BAS Medical for the treatment of congestive heart failure, cervical ripening and preeclampsia. Furthermore, relaxin shows enormous promise as an antifibrotic agent which has far-reaching therapeutic consequences since fibrosis is a hallmark of all forms of progressive cardiovascular and renal disease and obstructive airway disease (asthma), which collectively contribute to 40-50% of deaths in develope..

Related publications (3)

Signalling profiles of H3 relaxin, H2 relaxin and R3(B.23-27) R/I5 acting at the relaxin family peptide receptor 3 (RXFP3)

M Kocan, M Sarwar, MA Hossain, JD Wade, RJ Summers

2014-06-01

The Different Ligand-Binding Modes of Relaxin Family Peptide Receptors RXFP1 and RXFP2

Daniel J Scott, K Johan Rosengren, Ross AD Bathgate

2012-11-01

Resolving the Unconventional Mechanisms Underlying RXFP1 and RXFP2 Receptor Function

Brigham J Hartley, Daniel J Scott, Gabrielle E Callander, Tracey N Wilkinson, Despina E Ganella, Chze K Kong, Sharon Layfield, Tania Ferraro, Emma J Petrie, Ross AD Bathgate

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