The development of immune NKT cells in humans.
Grant number: 454363 | Funding period: 2007 - 2009
NKT cells are a type of white blood cell that help to control the function of the immune system. Many studies have reported an association between low NKT cell levels and increased rates of cancer and autoimmune diseases such as type 1 diabetes (T1D). Unfortunately, NKT cells are a relatively recent discovery and their function is not well understood, especially in humans. For example, it has only recently been discovered that there are different types of NKT cells with different functions. This lack of knowledge has prevented us from understanding how NKT cells normally prevent disease, and how we should treat diseases associated with low NKT cell numbers. In this project, we will study hum..View full description
Related publications (7)
The glucocorticoid receptor 1A3 promoter correlates with high sensitivity to glucocorticoid-induced apoptosis in human lymphocytes
Douglas R Liddicoat, Konstantinos Kyparissoudis, Stuart P Berzins, Timothy J Cole, Dale I Godfrey
Glucocorticoids (GCs) are powerful inhibitors of inflammation and immunity. Although glucocorticoid-induced cell death (GICD) is a..
Natural killer T cell defects in multiple myeloma and the impact of lenalidomide therapy
AC Chan, P Neeson, E Leeansyah, K Tainton, H Quach, HM Prince, SJ Harrison, DI Godfrey, D Ritchie, SP Berzins
The causes of multiple myeloma (MM) remain obscure and there are few known risk factors; however, natural killer T (NKT) cell abno..
Ex-vivo analysis of human Natural Killer T cells demonstrates heterogeneity between tissues and within established CD4( ) and CD4(-) subsets
AC Chan, E Leeansyah, A Cochrane, Y d'Udekem d'Acoz, D Mittag, LC Harrison, DI Godfrey, SP Berzins
Our understanding of human type 1 natural killer T (NKT) cells has been heavily dependent on studies of cells from peripheral bloo..
Testing the NKT cell hypothesis in lenalidomide-treated myelodysplastic syndrome patients
AC Chan, P Neeson, E Leeansyah, K Tainton, H Quach, HM Prince, DI Godfrey, D Ritchie, SP Berzins
Myelodysplastic syndrome (MDS) comprises a group of clonal bone marrow disorders characterized by ineffective hematopoiesis and in..
Immune characterization of an individual with an exceptionally high natural killer T cell frequency and her immediate family
AC Chan, L Serwecinska, A Cochrane, LC Harrison, DI Godfrey, SP Berzins
Natural killer T cells (NKT) are a regulatory subset of T lymphocytes whose frequency in peripheral blood is highly variable withi..
Peripheral NKT Cells in Simian Immunodeficiency Virus-Infected Macaques
Caroline S Fernandez, Angela C Chan, Konstantinos Kyparissoudis, Robert De Rose, Dale I Godfrey, Stephen J Kent
NKT cells are a specialized population of T lymphocytes that have an increasingly recognized role in immunoregulation, including c..
NKT cell development in the absence of the autoimmune regulator gene (Aire)
Lauren A Pitt, Francois-Xavier Hubert, Hamish S Scott, Dale I Godfrey, Stuart P Berzins
Autoimmune regulator gene (Aire)-deficient mice develop an array of autoimmune lesions that reflect failures of immune tolerance. ..