Interactions Between the Respiratory and Sympathetic Nervous Systems in High Blood Pressure.

Grant number: 454432 | Funding period: 2007 - 2009

Completed

Abstract

Hypertension is a common health disorder in all societies and is a major risk factor for the development of life threatening cardiovascular diseases, including heart failure and stroke. Whilst some effective therapies are available, many patients are not adequately treated or have reduced quality of life due to serious side effects. There is a great need for alternative therapies. The central nervous system is clearly involved in hypertension although the level of that involvement is not well understood- i.e. is it a causal factor or just a contributor to the maintenance of established hypertension? The experiments outlined in this application are based on the observation that modulation of ..

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Related publications (3)

Is augmented central respiratory-sympathetic coupling involved in the generation of hypertension?

AE Simms, JFR Paton, AM Allen, AE Pickering

2010-11-30

Respiratory modulation of autonomic neural activity, with consequent phasic alteration of cardiac and vascular function, has been ..

Amplified respiratory-sympathetic coupling in the spontaneously hypertensive rat: Does it contribute to hypertension?

AE Simms, JFR Paton, AE Pickering, AM Allen

2009-02-13

Sympathetic nerve activity (SNA) is elevated in established hypertension. We tested the hypothesis that SNA is elevated in neonate..

C1 neurons in the rat rostral ventrolateral medulla differentially express vesicular monoamine transporter 2 in soma and axonal compartments

CP Sevigny, J Bassi, AG Teschemacher, KS Kim, DA Williams, CR Anderson, AM Allen

2008-10-01

Vesicular monoamine transporter 2 (VMAT2) packages biogenic amines into large dense core and synaptic vesicles for either somatode..

University of Melbourne Researchers

Andrew Allen