Development of a synthetic peptide vaccine
Grant number: 454475 | Funding period: 2007 - 2009
Chronic periodontitis is a bacterial-associated inflammatory disease of the supporting tissues of the teeth, which results in the destruction of tooth support and ultimately leads to tooth loss. The disease is a major public health problem with a large economic burden. The bacterium Porphyromonas gingivalis has been identified as a major pathogen in the development of chronic periodontitis. We have identified and characterised a major virulence factor of P. gingivalis; a complex of proteins which is involved in binding and destruction of host tissue. We have shown that this protein complex when used as a vaccine protects against P. gingivalis induced disease in animal periodontitis models. W..View full description
Related publications (4)
The RgpA-Kgp Proteinase-Adhesin Complexes of Porphyromonas gingivalis Inactivate the Th2 Cytokines Interleukin-4 and Interleukin-5
Vivian Tam, Neil M O'Brien-Simpson, Yu-Yen Chen, Colin J Sanderson, Beverley Kinnear, Eric C Reynolds
The RgpA-Kgp proteinase-adhesin complexes are a primary virulence factor of Porphyromonas gingivalis, a major pathogen in the deve..
Identification and Suppression of beta-Elimination Byproducts Arising from the Use of Fmoc-Ser(PO(3)Bzl,H)-OH in Peptide Synthesis
Troy J Attard, Neil M O'Brien-Simpson, Eric C Reynolds
The formation of 3-(1-piperidinyl)alanyl-containing peptides via phosphoryl β-elimination was identified from the application of F..
Porphyromonas gingivalis RgpA-Kgp Proteinase-Adhesin Complexes Penetrate Gingival Tissue and Induce Proinflammatory Cytokines or Apoptosis in a Concentration-Dependent Manner
Neil M O'Brien-Simpson, Rishi D Pathirana, Glenn D Walker, Eric C Reynolds
The RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis were observed, using immunostaining, in human gingival tissu..