Control of Genioglossus During Sleep

Grant number: 454458 | Funding period: 2007 - 2010



Difficulty breathing during sleep is a major health problem. Obstructive Sleep Apnoea (OSA) is the most frequently occurring of these disorders, being found in approximately 4% of males and 2% of females. In OSA the upper airway (UA) collapses during sleep preventing airflow and causing a fall in oxygen levels in the blood. The airway collapses because during sleep muscles in the UA are unable to offset the negative pressure generated within the airway by the effort of inspiring. If the negative pressure is too great and the airway collapses the person has to wake up to reopen the airway. As the UA collapses again on the return of sleep, the cycle becomes repetitive, causing sleep disruption..

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University of Melbourne Researchers