Control of Genioglossus During Sleep
Grant number: 454458 | Funding period: 2007 - 2010
Difficulty breathing during sleep is a major health problem. Obstructive Sleep Apnoea (OSA) is the most frequently occurring of these disorders, being found in approximately 4% of males and 2% of females. In OSA the upper airway (UA) collapses during sleep preventing airflow and causing a fall in oxygen levels in the blood. The airway collapses because during sleep muscles in the UA are unable to offset the negative pressure generated within the airway by the effort of inspiring. If the negative pressure is too great and the airway collapses the person has to wake up to reopen the airway. As the UA collapses again on the return of sleep, the cycle becomes repetitive, causing sleep disruption..View full description
Related publications (2)
Motor Unit Recruitment in Human Genioglossus Muscle in Response to Hypercapnia
Christian L Nicholas, Bei Bei, Christopher Worsnop, Atul Malhotra, Amy S Jordan, Julian P Saboisky, Julia KM Chan, Ella Duckworth, David P White, John Trinder
STUDY OBJECTIVES: single motor unit recordings of the genioglossus (GG) muscle indicate that GG motor units have a variety of disc..
Discharge Patterns of Human Genioglossus Motor Units during Arousal from Sleep
Vanessa Wilkinson, Atul Malhotra, Christian L Nicholas, Christopher Worsnop, Amy S Jordan, Jane E Butler, Julian P Saboisky, Simon C Gandevia, David P White, John Trinder
STUDY OBJECTIVES: Single motor unit recordings of the human genioglossus muscle reveal motor units with a variety of discharge pat..