2007 PROGRAM GRANT - (IMMUNE REGULATION, EFFECTOR FUNCTION AND HUMAN IMMUNOTHERAPY)

T-NHL subtypes and clinical perspective

H Miles Prince

2021-07-01

JAK2 is dispensable for maintenance of JAK2 mutant B-cell acute lymphoblastic leukemias

Sang-Kyu Kim, Deborah A Knight, Lisa R Jones, Stephin Vervoort, Ashley P Ng, John F Seymour, James E Bradner, Michaela Waibel, Lev Kats, Ricky W Johnstone

2018-06-01

Activating JAK2 point mutations are implicated in the pathogenesis of myeloid and lymphoid malignancies, including high-risk B-cel..

BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members

Simon J Hogg, Andrea Newbold, Stephin J Vervoort, Leonie A Cluse, Benjamin P Martin, Gareth P Gregory, Marcus Lefebure, Eva Vidacs, Richard W Tothill, James E Bradner, Jake Shortt, Ricky W Johnstone

2016-09-01

Targeting BET bromodomain proteins using small molecules is an emerging anticancer strategy with clinical evaluation of at least s..

CD3(bright) signals on gamma delta T cells identify IL-17A-producing V gamma 6V delta 1( ) T cells

C Paget, MT Chow, NA Gherardin, PA Beavis, AP Uldrich, H Duret, M Hassane, F Souza-Fonseca-Guimaraes, DA Mogilenko, D Staumont-Salle, NK Escalante, GR Hill, P Neeson, DS Ritchie, D Dombrowicz, T Mallevaey, F Trottein, GT Belz, DI Godfrey, MJ Smyth

2015-02-01

Interleukin-17A (IL-17A) is a pro-inflammatory cytokine that has an important role at mucosal sites in a wide range of immune resp..

Natural killer T cell defects in multiple myeloma and the impact of lenalidomide therapy

AC Chan, P Neeson, E Leeansyah, K Tainton, H Quach, HM Prince, SJ Harrison, DI Godfrey, D Ritchie, SP Berzins

2014-01-01

The causes of multiple myeloma (MM) remain obscure and there are few known risk factors; however, natural killer T (NKT) cell abno..

NKT cells: the smoking gun in fungal-induced asthma?

Dale I Godfrey, Daniel G Pellicci, Jamie Rossjohn

2013-10-01

Aspergillus fumigatus is a fungus that is associated with a severe form of asthma, although the precise immunological basis for th..

In-vivo stimulation of macaque natural killer T cells with -galactosylceramide

CS Fernandez, S Jegaskanda, DI Godfrey, SJ Kent

2013-09-01

Natural killer T cells are a potent mediator of anti-viral immunity in mice, but little is known about the effects of manipulating..

Ex-vivo analysis of human Natural Killer T cells demonstrates heterogeneity between tissues and within established CD4( ) and CD4(-) subsets

AC Chan, E Leeansyah, A Cochrane, Y d'Udekem d'Acoz, D Mittag, LC Harrison, DI Godfrey, SP Berzins

2013-04-01

Our understanding of human type 1 natural killer T (NKT) cells has been heavily dependent on studies of cells from peripheral bloo..

Natural Killer T cell obsession with self-antigens

Laurent Gapin, Dale I Godfrey, Jamie Rossjohn

2013-04-01

Natural Killer T (NKT) cells are distinct lymphocyte lineages that recognize lipid antigens presented by the non-classical Major H..

Nfil3 Is a Glucocorticoid-Regulated Gene Required for Glucocorticoid-Induced Apoptosis in Male Murine T Cells

Kirstyn T Carey, Kheng H Tan, Judy Ng, Douglas R Liddicoat, Dale I Godfrey, Timothy J Cole

2013-04-01

Glucocorticoids (GCs) have essential roles in the regulation of development, integrated metabolism, and immune and neurological re..

Host immunity contributes to the anti-melanoma activity of BRAF inhibitors

Deborah A Knight, Shin Foong Ngiow, Ming Li, Tiffany Parmenter, Stephen Mok, Ashley Cass, Nicole M Haynes, Kathryn Kinross, Hideo Yagita, Richard C Koya, Thomas G Graeber, Antoni Ribas, Grant A McArthur, Mark J Smyth

2013-03-01

The BRAF mutant, BRAF(V600E), is expressed in nearly half of melanomas, and oral BRAF inhibitors induce substantial tumor regressi..

The interaction between murine melanoma and the immune system reveals that prolonged responses predispose for autoimmunity

Shin Foong Ngiow, Bianca von Scheidt, Andreas Moeller, Mark J Smyth, Michele WL Teng

2013-02-01

An assessment of antitumor immunity versus autoimmunity as provoked by the specific depletion of Foxp3+ Tregs is now possible with..

Cancer Immunoediting: From Surveillance to Escape

MWL Teng, MH Kershaw, MJ Smyth

2013-01-01

In 1957 Burnet and Thomas formulated the cancer immunosurveillance theory by hypothesizing that lymphocytes act as sentinels in re..

The mTORC1 Inhibitor Everolimus Prevents and Treats E mu-Myc Lymphoma by Restoring Oncogene-Induced Senescence

Meaghan Wall, Gretchen Poortinga, Kym L Stanley, Ralph K Lindemann, Michael Bots, Christopher J Chan, Megan J Bywater, Kathryn M Kinross, Megan V Astle, Kelly Waldeck, Katherine M Hannan, Jake Shortt, Mark J Smyth, Scott W Lowe, Ross D Hannan, Richard B Pearson, Ricky W Johnstone, Grant A McArthur

2013-01-01

UNLABELLED: MYC deregulation is common in human cancer. IG-MYC translocations that are modeled in Eμ-Myc mice occur in almost all ..

NLRP3 Suppresses NK Cell-Mediated Responses to Carcinogen-Induced Tumors and Metastases

Melvyn T Chow, Jaclyn Sceneay, Christophe Paget, Christina SF Wong, Helene Duret, Juerg Tschopp, Andreas Moeller, Mark J Smyth

2012-11-15

The NLRP3 inflammasome acts as a danger signal sensor that triggers and coordinates the inflammatory response upon infectious insu..

Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor

LM Lindqvist, I Vikstroem, JM Chambers, K McArthur, M Ann Anderson, KJ Henley, L Happo, L Cluse, RW Johnstone, AW Roberts, BT Kile, BA Croker, CJ Burns, MA Rizzacasa, A Strasser, DCS Huang

2012-10-01

There is significant interest in treating cancers by blocking protein synthesis, to which hematological malignancies seem particul..

Ex-vivo alpha-Galactosylceramide activation of NKT cells in humans and macaques

Caroline S Fernandez, Garth Cameron, Dale I Godfrey, Stephen J Kent

2012-08-31

NKT cells are key mediators of antiviral and anticancer immunity. Experiments in mice have demonstrated that activation of NKT cel..