2007 DEVELOPMENT GRANT - (DEVELOPMENT OF A MULTIPLEX ASSAY FOR THE IDENTIFICATION OF WOMEN AT RISK OF PRETERM LABOUR)

Grant number: 454451 | Funding period: 2007 - 2010

Completed

Abstract

Preterm birth (ie birth before the 37th week of gestation) is the most significant problem facing contemporary clinical obstetrics in the developed world and occurs in approximately 5% to 12% of all deliveries. Being born too early is the major cause of perinatal morbidity and mortality. Data from Australia indicate that each year, more than 17,000 babies will be born prematurely. Of these infants, over 10,000 will suffer respiratory complications and about 1300 will die during the first 21 days of life. The sickest and most premature of these infants require admission to a Neonatal Intensive Care Unit in a tertiary hospital. Aside from the medical implications of premature delivery, there i..

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Related publications (6)

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Human cervicovaginal fluid biomarkers to predict term and preterm labor

Yujing J Heng, Stella Liong, Michael Permezel, Gregory E Rice, Megan KW Di Quinzio, Harry M Georgiou

2015-05-13

Preterm birth (PTB; birth before 37 completed weeks of gestation) remains the major cause of neonatal morbidity and mortality. The..

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The Interplay of the Interleukin 1 System in Pregnancy and Labor

Yujing Jan Heng, Stella Liong, Michael Permezel, Gregory E Rice, Megan KW Di Quinzio, Harry M Georgiou

2014-01-01

This work assessed the temporal coexpression of interleukin 1 (IL-1) and its inhibitor, IL-1 receptor antagonist (IL-1ra), in the ..

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Temporal Investigation of Matrix Metalloproteinases and Their Inhibitors in Human Cervicovaginal Fluid in Late Pregnancy and Labor

Yujing J Heng, Megan KW Di Quinzio, Stella Liong, Michael Permezel, Gregory E Rice, Harry M Georgiou

2012-01-01

Temporal expression of matrix metalloproteinase (MMP)-1, -2, -3, -7, -8, -9, -12, and -13, and tissue inhibitors of metalloprotein..

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Cystatin A protease inhibitor and cysteine proteases in human cervicovaginal fluid in term pregnancy and labor

Yujing J Heng, Megan KW Di Quinzio, Michael Permezel, Gregory E Rice, Harry M Georgiou

2011-03-01

OBJECTIVE: The purpose of this study was to investigate the temporal changes in immunoreactive cystatin A and the enzymatic activi..

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Temporal Proteomic Analysis of Human Cervicovaginal Fluid with Impending Term Labor

Yujing J Heng, Megan KW Di Quinzio, Michael Permezel, Mustafa Ayhan, Gregory E Rice, Harry M Georgiou

2010-03-01

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Proteomic analysis of human cervico-vaginal fluid displays differential protein expression in association with labor onset at term

Megan KW Di Quinzio, Harry M Georgiou, Sarah J Holdsworth-Carson, Mustafa Ayhan, Yujing J Heng, Susan P Walker, Gregory E Rice, Michael Permezel

2008-05-01

Human labor is characterized by dramatic physiological and structural alterations of the cervix and overlying fetal membranes, lea..

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