2007 DEVELOPMENT GRANT - (DEVELOPMENT OF A MULTIPLEX ASSAY FOR THE IDENTIFICATION OF WOMEN AT RISK OF PRETERM LABOUR)
Grant number: 454451 | Funding period: 2007 - 2010
Preterm birth (ie birth before the 37th week of gestation) is the most significant problem facing contemporary clinical obstetrics in the developed world and occurs in approximately 5% to 12% of all deliveries. Being born too early is the major cause of perinatal morbidity and mortality. Data from Australia indicate that each year, more than 17,000 babies will be born prematurely. Of these infants, over 10,000 will suffer respiratory complications and about 1300 will die during the first 21 days of life. The sickest and most premature of these infants require admission to a Neonatal Intensive Care Unit in a tertiary hospital. Aside from the medical implications of premature delivery, there i..View full description
Related publications (6)
Human cervicovaginal fluid biomarkers to predict term and preterm labor
Yujing J Heng, Stella Liong, Michael Permezel, Gregory E Rice, Megan KW Di Quinzio, Harry M Georgiou
Preterm birth (PTB; birth before 37 completed weeks of gestation) remains the major cause of neonatal morbidity and mortality. The..
The Interplay of the Interleukin 1 System in Pregnancy and Labor
Yujing Jan Heng, Stella Liong, Michael Permezel, Gregory E Rice, Megan KW Di Quinzio, Harry M Georgiou
This work assessed the temporal coexpression of interleukin 1 (IL-1) and its inhibitor, IL-1 receptor antagonist (IL-1ra), in the ..
Temporal Investigation of Matrix Metalloproteinases and Their Inhibitors in Human Cervicovaginal Fluid in Late Pregnancy and Labor
Yujing J Heng, Megan KW Di Quinzio, Stella Liong, Michael Permezel, Gregory E Rice, Harry M Georgiou
Temporal expression of matrix metalloproteinase (MMP)-1, -2, -3, -7, -8, -9, -12, and -13, and tissue inhibitors of metalloprotein..
Cystatin A protease inhibitor and cysteine proteases in human cervicovaginal fluid in term pregnancy and labor
Yujing J Heng, Megan KW Di Quinzio, Michael Permezel, Gregory E Rice, Harry M Georgiou
OBJECTIVE: The purpose of this study was to investigate the temporal changes in immunoreactive cystatin A and the enzymatic activi..
Proteomic analysis of human cervico-vaginal fluid displays differential protein expression in association with labor onset at term
Megan KW Di Quinzio, Harry M Georgiou, Sarah J Holdsworth-Carson, Mustafa Ayhan, Yujing J Heng, Susan P Walker, Gregory E Rice, Michael Permezel
Human labor is characterized by dramatic physiological and structural alterations of the cervix and overlying fetal membranes, lea..