DEVELOPMENT OF DRUGS THAT BLOCK ACTIVITY AS ANTI-DEMENTIA AGENTS
Grant number: 454714 | Funding period: 2007 - 2007
This research project provides proof of concept that IRAP is a suitable target for use in the development of a new class of clinically valuable cognitive-enhancing agents. We have recently Identified a family of small molecule compounds that inhibited the catalytic activity of the enzyme using a molecule model of IRAP to screen virtual libraries. This research proposal aims to validate that this family of compounds have memory-enhancing properties by acting specifically on IRAP. At the conclusion of this project, we will have elucidated important information on the specificity of the memory effects and the structure activity relationship of this family of compounds. We will have identified a..View full description
Related publications (3)
Synthesis, Structure-Activity Relationships and Brain Uptake of a Novel Series of Benzopyran Inhibitors of Insulin-Regulated Aminopeptidase
Simon J Mountford, Anthony L Albiston, William N Charman, Leelee Ng, Jessica K Holien, Michael W Parker, Joseph A Nicolazzo, Philip E Thompson, Siew Yeen Chai
Peptide inhibitors of insulin-regulated aminopeptidase (IRAP) enhance fear avoidance and spatial memory and accelerate spatial lea..
Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase
Siew Yeen Chai, Holly R Yeatman, Michael W Parker, David B Ascher, Philip E Thompson, Hayley T Mulvey, Anthony L Albiston
The peptides angiotensin IV and LVV-hemorphin 7 were found to enhance memory in a number of memory tasks and reverse the performan..
Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase
Anthony L Albiston, Craig J Morton, Hooi Ling Ng, Vi Pham, Holly R Yeatman, Siying Ye, Ruani N Fernando, Dimitri De Bundel, David B Ascher, Frederick AO Mendelsohn, Michael W Parker, Siew Yeen Chai
Approximately one-quarter of people over the age of 65 are estimated to suffer some form of cognitive impairment, underscoring the..