EXPANSION OF TGF-BETA-SMAD SIGNALING NETWORK AND INTRINSIC EPITHELIAL-MESENCHYMAL TRANSITION
Grant number: 433619 | Funding period: 2007 - 2010
The majority of tumor death occurs due to tumor metastasis. Both tumor growth and tumor spread require angiogenesis, which is thought to be driven by tumor but originated from host endothelial cells. Could tumor cells behave and function like endothelial cells? This application aims to detect the transition of adult epithelial cells to endothelial cells through a transient mesenchymal state. Our studies should reveal both the molecular and cellular causes of vasculogenic mimicry, thus establishing a new paradigm in understanding tumor growth and metastasis. Such novel molecular understanding will open up new anti-tumor therapeutic opportunities.
Related publications (5)
Oncogenic H-Ras Reprograms Madin-Darby Canine Kidney (MDCK) Cell-derived Exosomal Proteins Following Epithelial-Mesenchymal Transition
Bow J Tauro, Rommel A Mathias, David W Greening, Shashi K Gopal, Hong Ji, Eugene A Kapp, Bradley M Coleman, Andrew F Hill, Ulrike Kusebauch, Janice L Hallows, David Shteynberg, Robert L Moritz, Hong-Jian Zhu, Richard J Simpson
Tandem application of cationic colloidal silica and Triton X-114 for plasma membrane protein isolation and purification: Towards developing an MDCK protein database
Rommel A Mathias, Yuan-Shou Chen, Robert JA Goode, Eugene A Kapp, Suresh Mathivanan, Robert L Moritz, Hong-Jian Zhu, Richard J Simpson