EXPANSION OF TGF-BETA-SMAD SIGNALING NETWORK AND INTRINSIC EPITHELIAL-MESENCHYMAL TRANSITION

Grant number: 433619 | Funding period: 2007 - 2010

Completed

Abstract

The majority of tumor death occurs due to tumor metastasis. Both tumor growth and tumor spread require angiogenesis, which is thought to be driven by tumor but originated from host endothelial cells. Could tumor cells behave and function like endothelial cells? This application aims to detect the transition of adult epithelial cells to endothelial cells through a transient mesenchymal state. Our studies should reveal both the molecular and cellular causes of vasculogenic mimicry, thus establishing a new paradigm in understanding tumor growth and metastasis. Such novel molecular understanding will open up new anti-tumor therapeutic opportunities.

Researchers