Identifying mitogenic signalling proteins with phosphatidyl inositol lipids
Grant number: DP0770668
Health care of an ageing population is a national priority of the community. In order to understand the factors that control cell growth and death in cancer cells signalling proteins can be identified and studied and compared with model systems from quiescent cells. Using phospholipids attached to 'fishing lines' we can search for, identify and study the function of all the downstream signalling proteins in activated cancer cells. This will provide the basic information for drug discovery processes to target specific molecules that inhibit and control the function of the signalling proteins implicated in the growth of cancer cells.
Related publications (3)
Analysis of cellular phosphatidylinositol (3,4,5)-trisphosphate levels and distribution using confocal fluorescent microscopy
Michelle Palmieri, Cameron J Nowell, Melanie Condron, James Gardiner, Andrew B Holmes, Jayesh Desai, Antony W Burgess, Bruno Catimel
We have developed an immunocytochemistry method for the semiquantitative detection of phosphatidylinositol (3,4,5)-trisphosphate (..
Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes
Stuart J Conway, James Gardiner, Simon JA Grove, Melloney K Johns, Ze-Yi Lim, Gavin F Painter, Diane EJE Robinson, Christine Schieber, Jan W Thuring, Leon S-M Wong, Meng-Xin Yin, Antony W Burgess, Bruno Catimel, Phillip T Hawkins, Nicholas T Ktistakis, Leonard R Stephens, Andrew B Holmes
The synthesis of the complete family of phosphatidylinositol phosphate analogues (PIPs) from five key core intermediates A-E is de..
Synthesis and biological evaluation of a novel cardiolipin affinity matrix
Melloney K Johns, Meng-Xin Yin, Stuart J Conway, Diane EJE Robinson, Leon S-M Wong, Rebecca Bamert, Richard EH Wettenhall, Andrew B Holmes
Cardiolipin (1) is a dimeric phospholipid found in the mitochondrial membranes of both plants and animals. In order to understand ..