2007 PROGRAM GRANT - (IMMUNE REGULATION, EFFECTOR FUNCTION AND HUMAN IMMUNOTHERAPY)

A systematic review on the management of pruritus in patients with cutaneous T-cell lymphoma

Georgia Farrah, Odette Spruijt, Chris McCormack, Odette Buelens, Smaro Lazarakis, Miles Prince

CDK4/6 Inhibition Promotes Antitumor Immunity through the Induction of T-cell Memory

Emily J Lelliott, Isabella Y Kong, Magnus Zethoven, Kelly M Ramsbottom, Luciano G Martelotto, Deborah Meyran, Joe Jiang Zhu, Matteo Costacurta, Laura Kirby, Jarrod J Sandow, Lydia Lim, Pilar M Dominguez, Izabela Todorovski, Nicole M Haynes, Paul A Beavis, Paul J Neeson, Edwin D Hawkins, Grant A McArthur, Ian A Parish, Ricky W Johnstone

2021-10-01

Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) are an approved treatment for hormone receptor-positive brea..

T-NHL subtypes and clinical perspective

H Miles Prince

2021-07-01

Serine Biosynthesis Is a Metabolic Vulnerability in FLT3-ITD-Driven Acute Myeloid Leukemia

Stefan Bjelosevic, Emily Gruber, Andrea Newbold, Carolyn Shembrey, Jennifer R Devlin, Simon J Hogg, Lev Kats, Izabela Todorovski, Zheng Fan, Thomas C Abrehart, Giovanna Pomilio, Andrew Wei, Gareth P Gregory, Stephin J Vervoort, Kristin K Brown, Ricky W Johnstone

2021-06-01

Internal tandem duplication of the FMS-like tyrosine kinase 3 gene (FLT3-ITD) occurs in 30% of all acute myeloid leukemias (AML). ..

Epigenetic reprogramming of plasmacytoid dendritic cells drives type I interferon-dependent differentiation of acute myeloid leukemias for therapeutic benefit

Jessica Salmon, Izabela Todorovski, Stephin Vervoort, Kym Stanley, Conor Kearney, Luciano Martelotto, Fernando Rossello, Tim Semple, Gisela Mir-Arnau, Magnus Zethoven, Michael Bots, Eva Vidacs, Kate McArthur, Elise Gressier, Nicky de Weerd, Jens Lichte, Madison Kelly, Leonie Cluse, Simon Hogg, Paul Hertzog

2020-08-24

Pharmacological inhibition of epigenetic enzymes can have therapeutic benefit, particularly against hematological malignancies. Wh..

CDK13 cooperates with CDK12 to control global RNA polymerase II processivity

Zheng Fan, Jennifer R Devlin, Simon J Hogg, Maria A Doyle, Paul F Harrison, Izabela Todorovski, Leonie A Cluse, Deborah A Knight, Jarrod J Sandow, Gareth Gregory, Andrew Fox, Traude H Beilharz, Nicholas Kwiatkowski, Nichollas E Scott, Ana Tufegdzic Vidakovic, Gavin P Kelly, Jesper Q Svejstrup, Matthias Geyer, Nathanael S Gray, Stephin J Vervoort

2020-04-01

The RNA polymerase II (POLII)-driven transcription cycle is tightly regulated at distinct checkpoints by cyclin-dependent kinases ..

JAK2 is dispensable for maintenance of JAK2 mutant B-cell acute lymphoblastic leukemias

Sang-Kyu Kim, Deborah A Knight, Lisa R Jones, Stephin Vervoort, Ashley P Ng, John F Seymour, James E Bradner, Michaela Waibel, Lev Kats, Ricky W Johnstone

2018-06-01

Activating JAK2 point mutations are implicated in the pathogenesis of myeloid and lymphoid malignancies, including high-risk B-cel..

CD3(bright) signals on gamma delta T cells identify IL-17A-producing V gamma 6V delta 1( ) T cells

C Paget, MT Chow, NA Gherardin, PA Beavis, AP Uldrich, H Duret, M Hassane, F Souza-Fonseca-Guimaraes, DA Mogilenko, D Staumont-Salle, NK Escalante, GR Hill, P Neeson, DS Ritchie, D Dombrowicz, T Mallevaey, F Trottein, GT Belz, DI Godfrey, MJ Smyth

2015-02-01

Interleukin-17A (IL-17A) is a pro-inflammatory cytokine that has an important role at mucosal sites in a wide range of immune resp..

Induction of potent NK cell-dependent anti-myeloma cytotoxic T cells in response to combined mapatumumab and bortezomib

Paul J Neeson, Andy K Hsu, Yin R Chen, Heloise M Halse, Joanna Loh, Reece Cordy, Kate Fielding, Joanne Davis, Josh Noske, Alex J Davenport, Camilla A Lindqvist-Gigg, Robin Humphreys, Tsin Tai, H Miles Prince, Joseph A Trapani, Mark J Smyth, David S Ritchie

2015-01-01

There is increasing evidence that some cancer therapies can promote tumor immunogenicity to boost the endogenous antitumor immune ..

The glucocorticoid receptor 1A3 promoter correlates with high sensitivity to glucocorticoid-induced apoptosis in human lymphocytes

Douglas R Liddicoat, Konstantinos Kyparissoudis, Stuart P Berzins, Timothy J Cole, Dale I Godfrey

2014-11-01

Glucocorticoids (GCs) are powerful inhibitors of inflammation and immunity. Although glucocorticoid-induced cell death (GICD) is a..

Natural killer T cell defects in multiple myeloma and the impact of lenalidomide therapy

AC Chan, P Neeson, E Leeansyah, K Tainton, H Quach, HM Prince, SJ Harrison, DI Godfrey, D Ritchie, SP Berzins

2014-01-01

The causes of multiple myeloma (MM) remain obscure and there are few known risk factors; however, natural killer T (NKT) cell abno..

NKT cells: the smoking gun in fungal-induced asthma?

Dale I Godfrey, Daniel G Pellicci, Jamie Rossjohn

2013-10-01

Aspergillus fumigatus is a fungus that is associated with a severe form of asthma, although the precise immunological basis for th..

In-vivo stimulation of macaque natural killer T cells with -galactosylceramide

CS Fernandez, S Jegaskanda, DI Godfrey, SJ Kent

2013-09-01

Natural killer T cells are a potent mediator of anti-viral immunity in mice, but little is known about the effects of manipulating..

Ex-vivo analysis of human Natural Killer T cells demonstrates heterogeneity between tissues and within established CD4( ) and CD4(-) subsets

AC Chan, E Leeansyah, A Cochrane, Y d'Udekem d'Acoz, D Mittag, LC Harrison, DI Godfrey, SP Berzins

2013-04-01

Our understanding of human type 1 natural killer T (NKT) cells has been heavily dependent on studies of cells from peripheral bloo..

Natural Killer T cell obsession with self-antigens

Laurent Gapin, Dale I Godfrey, Jamie Rossjohn

2013-04-01

Natural Killer T (NKT) cells are distinct lymphocyte lineages that recognize lipid antigens presented by the non-classical Major H..

Nfil3 Is a Glucocorticoid-Regulated Gene Required for Glucocorticoid-Induced Apoptosis in Male Murine T Cells

Kirstyn T Carey, Kheng H Tan, Judy Ng, Douglas R Liddicoat, Dale I Godfrey, Timothy J Cole

2013-04-01

Glucocorticoids (GCs) have essential roles in the regulation of development, integrated metabolism, and immune and neurological re..

Host immunity contributes to the anti-melanoma activity of BRAF inhibitors

Deborah A Knight, Shin Foong Ngiow, Ming Li, Tiffany Parmenter, Stephen Mok, Ashley Cass, Nicole M Haynes, Kathryn Kinross, Hideo Yagita, Richard C Koya, Thomas G Graeber, Antoni Ribas, Grant A McArthur, Mark J Smyth

2013-03-01

The BRAF mutant, BRAF(V600E), is expressed in nearly half of melanomas, and oral BRAF inhibitors induce substantial tumor regressi..

The interaction between murine melanoma and the immune system reveals that prolonged responses predispose for autoimmunity

Shin Foong Ngiow, Bianca von Scheidt, Andreas Moeller, Mark J Smyth, Michele WL Teng

2013-02-01

An assessment of antitumor immunity versus autoimmunity as provoked by the specific depletion of Foxp3+ Tregs is now possible with..

Cancer Immunoediting: From Surveillance to Escape

MWL Teng, MH Kershaw, MJ Smyth

2013-01-01

In 1957 Burnet and Thomas formulated the cancer immunosurveillance theory by hypothesizing that lymphocytes act as sentinels in re..

The mTORC1 Inhibitor Everolimus Prevents and Treats E mu-Myc Lymphoma by Restoring Oncogene-Induced Senescence

Meaghan Wall, Gretchen Poortinga, Kym L Stanley, Ralph K Lindemann, Michael Bots, Christopher J Chan, Megan J Bywater, Kathryn M Kinross, Megan V Astle, Kelly Waldeck, Katherine M Hannan, Jake Shortt, Mark J Smyth, Scott W Lowe, Ross D Hannan, Richard B Pearson, Ricky W Johnstone, Grant A McArthur

2013-01-01

UNLABELLED: MYC deregulation is common in human cancer. IG-MYC translocations that are modeled in Eμ-Myc mice occur in almost all ..

NLRP3 Suppresses NK Cell-Mediated Responses to Carcinogen-Induced Tumors and Metastases

Melvyn T Chow, Jaclyn Sceneay, Christophe Paget, Christina SF Wong, Helene Duret, Juerg Tschopp, Andreas Moeller, Mark J Smyth

2012-11-15

The NLRP3 inflammasome acts as a danger signal sensor that triggers and coordinates the inflammatory response upon infectious insu..

Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor

LM Lindqvist, I Vikstroem, JM Chambers, K McArthur, M Ann Anderson, KJ Henley, L Happo, L Cluse, RW Johnstone, AW Roberts, BT Kile, BA Croker, CJ Burns, MA Rizzacasa, A Strasser, DCS Huang

2012-10-01

There is significant interest in treating cancers by blocking protein synthesis, to which hematological malignancies seem particul..

Ex-vivo alpha-Galactosylceramide activation of NKT cells in humans and macaques

Caroline S Fernandez, Garth Cameron, Dale I Godfrey, Stephen J Kent

2012-08-31

NKT cells are key mediators of antiviral and anticancer immunity. Experiments in mice have demonstrated that activation of NKT cel..

Inflammation and immune surveillance in cancer

Melvyn T Chow, Andreas Moeller, Mark J Smyth

2012-02-01

Chronic inflammation is a risk factor for tumor development. However, understanding the effect of the immune system on tumor devel..

The immunostimulatory effect of lenalidomide on NK-cell function is profoundly inhibited by concurrent dexamethasone therapy

Andy K Hsu, Hang Quach, Tsin Tai, H Miles Prince, Simon J Harrison, Joseph A Trapani, Mark J Smyth, Paul Neeson, David S Ritchie

2011-02-03

Lenalidomide combined with dexamethasone is an effective treatment for refractory/relapsed multiple myeloma (MM). Lenalidomide sti..

Distinct roles in NKT cell maturation and function for the different transcription factors in the classical NF-kappa B pathway

Sanda Stankovic, Raffi Gugasyan, Konstantinos Kyparissoudis, Raelene Grumont, Ashish Banerjee, Philip Tsichlis, Steve Gerondakis, Dale I Godfrey

2011-02-01

The nuclear factor (NF)-κB signalling pathway is known to be critical for natural killer T (NKT) cell differentiation; however, th..

Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L

Spela Konjar, Vivien R Sutton, Sabine Hoves, Urska Repnik, Hideo Yagita, Thomas Reinheckel, Christoph Peters, Vito Turk, Boris Turk, Joseph A Trapani, Natasa Kopitar-Jerala

2010-10-01

The pore-forming protein perforin is synthesized as an inactive precursor in natural killer (NK) cells and cytotoxic T lymphocytes..

Ex vivo culture of chimeric antigen receptor T cells generates functional CD8( ) T cells with effector and central memory-like phenotype

P Neeson, A Shin, KM Tainton, P Guru, HM Prince, SJ Harrison, S Peinert, MJ Smyth, JA Trapani, MH Kershaw, PK Darcy, DS Ritchie

2010-09-01

The anti-tumor efficacy of adoptively transferred T cells requires their in vivo persistence and memory polarization. It is unknow..

Cathepsin H Is an Additional Convertase of Pro-granzyme B

Michael E D'Angelo, Phillip I Bird, Christoph Peters, Thomas Reinheckel, Joseph A Trapani, Vivien R Sutton

2010-07-02

The serine protease granzyme B (GrB) is the most potent proapoptotic cytotoxin of the granule exocytosis pathway of cytotoxic lymp..

Testing the NKT cell hypothesis in lenalidomide-treated myelodysplastic syndrome patients

AC Chan, P Neeson, E Leeansyah, K Tainton, H Quach, HM Prince, DI Godfrey, D Ritchie, SP Berzins

2010-03-01

Myelodysplastic syndrome (MDS) comprises a group of clonal bone marrow disorders characterized by ineffective hematopoiesis and in..

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism

Dimitra Zotos, Jonathan M Coquet, Yang Zhang, Amanda Light, Kathy D'Costa, Axel Kallies, Lynn M Corcoran, Dale I Godfrey, Kai-Michael Toellner, Mark J Smyth, Stephen L Nutt, David M Tarlinton

2010-02-15

Germinal centers (GCs) are sites of B cell proliferation, somatic hypermutation, and selection of variants with improved affinity ..

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis

Lorraine A O' Reilly, Lin Tai, Lily Lee, Elizabeth A Kruse, Stephanie Grabow, W Douglas Fairlie, Nicole M Haynes, David M Tarlinton, Jian-Guo Zhang, Gabrielle T Belz, Mark J Smyth, Philippe Bouillet, Lorraine Robb, Andreas Strasser

2009-10-01

Fas ligand (FasL), an apoptosis-inducing member of the TNF cytokine family, and its receptor Fas are critical for the shutdown of ..

Type I natural killer T cells suppress tumors caused by p53 loss in mice

Jeremy B Swann, Adam P Uldrich, Serani van Dommelen, Janelle Sharkey, William K Murray, Dale I Godfrey, Mark J Smyth

2009-06-18

CD1d-restricted T cells are considered to play a host protective effect in tumor immunity, yet the evidence for a role of natural ..

Immune characterization of an individual with an exceptionally high natural killer T cell frequency and her immediate family

AC Chan, L Serwecinska, A Cochrane, LC Harrison, DI Godfrey, SP Berzins

2009-05-01

Natural killer T cells (NKT) are a regulatory subset of T lymphocytes whose frequency in peripheral blood is highly variable withi..

Peripheral NKT Cells in Simian Immunodeficiency Virus-Infected Macaques

Caroline S Fernandez, Angela C Chan, Konstantinos Kyparissoudis, Robert De Rose, Dale I Godfrey, Stephen J Kent

2009-02-15

NKT cells are a specialized population of T lymphocytes that have an increasingly recognized role in immunoregulation, including c..

Osteoclast Inhibitory Lectin, an Immune Cell Product That Is Required for Normal Bone Physiology in Vivo

Vicky Kartsogiannis, Natalie A Sims, Julian MW Quinn, Chi Ly, Mirijana Cipetic, Ingrid J Poulton, Emma C Walker, Hasnawati Saleh, Narelle E McGregor, Morgan E Wallace, Mark J Smyth, T John Martin, Hong Zhou, Kong Wah Ng, Matthew T Gillespie

2008-11-07

Osteoclast inhibitory lectin (OCIL or clrb) is a member of the natural killer cell C-type lectins that have a described role mostl..

NKT cell development in the absence of the autoimmune regulator gene (Aire)

Lauren A Pitt, Francois-Xavier Hubert, Hamish S Scott, Dale I Godfrey, Stuart P Berzins

2008-10-01

Autoimmune regulator gene (Aire)-deficient mice develop an array of autoimmune lesions that reflect failures of immune tolerance. ..

Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4(-)NK1.1(-) NKT cell population

Jonathan M Coquet, Sumone Chakravarti, Konstantinos Kyparissoudis, Finlay W McNab, Lauren A Pitt, Brent S McKenzie, Stuart P Berzins, Mark J Smyth, Dale I Godfrey

2008-08-12

NKT cell subsets can be divided based on CD4 and NK1.1 expression and tissue of origin, but the developmental and functional relat..

Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis

Vivien R Sutton, Nigel J Waterhouse, Kylie A Browne, Karin Sedelies, Annette Ciccone, Desiree Anthony, Aulikki Koskinen, Arno Mullbacher, Joseph A Trapani

2007-02-12

Cathepsin C activates serine proteases expressed in hematopoietic cells by cleaving an N-terminal dipeptide from the proenzyme upo..